the Key Scientific Research Project of Guangdong Provincial Department of Education(2020ZDZX2020);the National Natural Science Foundation of China(52072082;32101143;52302086;52372078);the Guangdong Basic and Applied Basic Research Foundation(2023A1515010299);the open research funds from the Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital(202011-105)