最新刊期

    47 6 2026

      Cover Story

    • FAN Shiyi, ZHENG Yueting, CHEN Xuwen, CHEN Bowen, CHEN Weiguo, YANG Kaiyu
      Vol. 47, Issue 6, Pages: 901-908(2026) DOI: 10.37188/CJL.20260028
      摘要:Quasi-two-dimensional perovskites, with their excellent optoelectronic properties, high luminous efficiency, and solution-processable characteristics, have become ideal materials for next-generation high-resolution displays. However, in high-resolution display applications, traditional patterning techniques struggle to balance high resolution, high fidelity, and the quality of perovskite films. Printing technology has limited resolution and is prone to the ‘coffee-ring’ effect. Photolithography carries the risk of light-induced damage and involves complex processes. Laser direct writing is costly and has low material utilization. To address this, we propose a high-resolution patterning strategy based on thermal nanoimprinting combined with hydrophilic-hydrophobic template-induced crystallization. By using plasma surface modification to create a honeycomb polymethyl methacrylate (PMMA) film with contrasting wettability, we leverage interfacial energy gradients to drive the selective localized growth of perovskite precursor solutions in predefined hydrophilic areas, achieving perovskite microarrays with clear boundaries and uniform density. The high-resolution perovskite light-emitting diodes (PeLEDs) fabricated using this method show an emission peak at 527 nm, a maximum external quantum efficiency (EQE) of 7.24%, and a maximum brightness of 9 474 cd·m-2. This work provides a patterning approach for the fabrication of high-performance perovskite micro-displays that combines high resolution, simple processing, and excellent film quality.  
      关键词:perovskite;in situ growth;High-resolution;patterning;crystal control   
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      Invited Review

    • Nitride Optoelectronic Brain-inspired Neuromorphic Devices 增强出版 AI导读

      ZHAO Jianlu, WU Yunfei, HU Lingxiang, LIU Wei, LU Huanming, YE Zhizhen, ZHUGE Fei
      Vol. 47, Issue 6, Pages: 909-934(2026) DOI: 10.37188/CJL.20260057
      摘要:To address the increasingly severe challenge of the separation of memory and processor modules in the era of artificial intelligence, neuromorphic computing inspired by the biological brain has emerged as an ideal approach to break through the bottleneck of the traditional von Neumann architecture. Optoelectronic devices that integrate the advantages of light and electrical signals have attracted much attention due to their potential for high speed, low crosstalk, and integration of sensing, storage, and computing. Nitride semiconductors represented by boron nitride, gallium nitride, aluminum nitride, and their alloys provide an ideal material platform for building high-performance optoelectronic devices due to their wide tuning range of band gap and excellent optoelectronic properties. This review systematically presents the latest progress and applications of nitride optoelectronic neuromorphic devices. Firstly, the biological neurons and synapses were introduced. Then, from aspects such as device structure, working mechanism, and neural morphological function simulation, the nitride-based artificial synapses and artificial neuron devices were analyzed in depth. Next, the application prospects of these devices were explored in fields such as artificial vision, logical operations and biomedicine. Finally, the challenges in materials, devices, and large-scale integration were discussed, and future development directions, such as multimodal fusion perception and heterogeneous integration, were prospected. This work aims to clarify the development trajectory of nitride optoelectronic neuromorphic devices and provide a reference for developing the next-generation high-efficiency, and high-speed intelligent computing hardware.  
      关键词:brain-inspired neuromorphic devices;optoelectronic devices;artificial synapses;artificial neurons;nitrides   
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    • LIU Lingyun, ZHANG Yuhai
      Vol. 47, Issue 6, Pages: 935-947(2026) DOI: 10.37188/CJL.20260032
      摘要:The application of radiation-related technologies in fields such as medical diagnosis and nuclear industry monitoring is becoming increasingly widespread, placing higher demands on the comprehensive performance of detection and protective materials. Traditional inorganic scintillation crystals, organic plastic scintillators, and lead-based shielding materials all suffer from inherent limitations, making it difficult to balance performance with practical application requirements. High-loading transparent composites overcome the fundamental conflict between “filler loading” and “optical transparency” by utilizing a high density of functional nanounits to enhance radiation interaction efficiency, while maintaining excellent optical transparency to ensure signal transmission. Consequently, these composites have emerged as a major research focus in the field of radiation materials. This article systematically reviews their synthesis strategies, focusing on application progress in the three core areas of radiation detection, imaging and shielding. It also summarizes current challenges and future directions, aiming to provide guidance for material optimization and industrial application.  
      关键词:high-loading transparent composites;radiation detection;radiation imaging;radiation protection   
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      Editor's Choice

    • ZONG Chi, LI Suen, BAI Xue, LIU Yue, CUN Yangke, SONG Zhiguo, QIU Jianbei, HUANG Anjun, YANG Zhengwen
      Vol. 47, Issue 6, Pages: 948-959(2026) DOI: 10.37188/CJL.20260040
      摘要:This study aims to develop a novel high-performance material that integrates photochromic and upconversion luminescence (UCL) properties to overcome the limitations of current materials regarding response speed and high color contrast, thereby enabling efficient optical information storage and anti-counterfeiting applications. A series of Ba2YSbO6∶Er3+,Yb3+ (abbreviated as BYSO∶Er3+,Yb3+) double perovskite phosphors were synthesized via a high-temperature solid-state reaction method. Under 254 nm (5 W) UV light irradiation, the samples exhibit a color change from white to yellow, reaching photochromic saturation in only 5 s. This demonstrates an ultra-fast photochromic response speed, and the coloration can be bleached under 405 nm light. The photochromic mechanism and upconversion luminescence behavior were systematically characterized using diffuse reflectance spectra, UCL spectra, thermoluminescence (TL) curves, X-ray photoelectron spectroscopy (XPS), and fluorescence decay curves. By combining the photochromic effect with luminescent characteristics, reversible UCL modulation induced by photochromism was achieved. Furthermore, flexible films based on these phosphors successfully demonstrated the processes of information writing, reading, and erasing, highlighting their promising potential as optical storage media and security anti-counterfeiting materials.  
      关键词:Double perovskite oxide;Fast photochromism;color center;Upconversion luminescence modulation;Optical security   
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    • Polishing-free Perovskite Single Crystals for Self-powered Photodetection 增强出版 AI导读

      YU Di, GAO Feng, LI Lin
      Vol. 47, Issue 6, Pages: 960-969(2026) DOI: 10.37188/CJL.20260035
      摘要:Traditional perovskite single-crystal optoelectronic devices typically rely on mechanical polishing to achieve flat interfaces. However, this process inevitably introduces severe lattice damage and deep-level defects, leading to increased dark current and significantly heightened noise in the devices, which severely limits their performance. To address these issues, this paper proposes a silicon wafer-assisted seed-reverse-temperature crystallization growth strategy. By leveraging the atomically flat surface of silicon wafers to regulate nucleation and growth behavior, it successfully achieves controlled growth of high-quality perovskite single crystals, directly yielding flat, growth-texture-free native surfaces. Self-driven photodetectors were constructed using gold/silver asymmetric electrodes, systematically investigating photoresponse characteristics under visible light and X-ray irradiation with both front and back illumination. At 0 V bias, the device exhibited a low dark current of 0.014 5 nA, a high on/off ratio of 196 under 500 nm front illumination, and a maximum responsivity of 2.44 mA·W-1. When light was incident from the rear, the response shifted from broadband to narrowband. X-ray testing revealed a sensitivity of 3 487 μC·Gyair-1·cm-2 at 0 V bias, with a detection limit as low as 21.99 nGyair·s-1. This study provides a simple polishing-free approach for constructing high-quality perovskite single-crystal interfaces, offering a novel technological pathway for developing ultra-sensitive, low-cost perovskite single-crystal photodetectors.  
      关键词:perovskite single crystal;single crystal growth;photodetector;X-ray detection   
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      Rebirth after rejection by SCI journals

    • CHEN Mingming, LIU Kangyuan, ZHANG Huimin, LIU Yuan, WU Chunxia, CAO Dawei
      Vol. 47, Issue 6, Pages: 970-982(2026) DOI: 10.37188/CJL.20260088
      摘要:B-site metal doping has potentials to suppress both the point defects and boundary defects of lead halide perovskites, while the differences in ionic radii of dopants and parent atoms induce remarkable local strains that severely limit the sizes of crystalline grains in thin films. Herein, FA has been introduced into Co-doped MAPbI3 to relax the local strains to improve the qualities of MAPbI3 thin films. Experimental and theoretical studies suggest that Co doping induced remarkable local tensile strains, which are effectively relaxed by doping FA. Further studies suggest that doping of FA decreases the boundary defects and tunes the Fermi energy of Co-doped MAPbI3 thin films simultaneously, which effectively suppresses non-radiative recombination and improves the carrier transport at MAPbI3/ITO interfaces. On these bases, efficient transport layer-free MAPbI3/ITO photodetectors with the responsivity and external quantum efficiency (EQE) as high as 0.094 A/W and 28% at zero bias have been achieved. These results have provided promising pathways for obtaining efficient transport-layer-free perovskite photodetectors in the future.  
      关键词:Co doped;Co-FA codoping;Strain relaxation;Efficient photodetection;MAPbI3/ITO   
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      Synthesis and Properties of Materials

    • QIN Jinlan, WANG Qiansong, SHI Kunheng, HU Chaofan
      Vol. 47, Issue 6, Pages: 983-996(2026) DOI: 10.37188/CJL.20260043
      摘要:Carbon dots (CDs) have attracted considerable attention due to their unique optical properties, excellent biocompatibility, and ease of functionalization. However, CDs are prone to aggregation-induced fluorescence quenching in the solid state and exhibit poor stability under harsh conditions such as strong acids and alkalis, which greatly limits their practical application range. The combination of CDs with a silica (SiO2) matrix to form CDs/SiO2 composites not only uniformly disperses CDs in the SiO2 matrix, effectively inhibits non-radiative transitions, and significantly improves their fluorescence quantum yield as well as photothermal and chemical stability, but also induces or enhances the room-temperature phosphorescence properties of CDs through confinement effects and interfacial interactions. In addition, the porosity and functionalizable surface of SiO2 provide an ideal platform for constructing function-integrated intelligent composites. Given the rapid development of CDs/SiO2 composites in fields such as sensing, bioimaging, optoelectronic devices, information encryption, and catalysis, this paper systematically summarizes their preparation methods, optimization mechanisms of optical properties, and application fields, and discusses the current challenges and future research directions, providing a theoretical basis and research ideas for subsequent studies in this field.  
      关键词:carbon dots;silica;luminescent properties;sensing technology;bioimaging   
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    • NIU Jinyan, CHENG Chen, YU Xiaobo, HE Shuai, GUAN Qian, SHEN Yu, LI He, QIAO Jun, CHAO Luomeng, MA Yonghong
      Vol. 47, Issue 6, Pages: 997-1007(2026) DOI: 10.37188/CJL.20260084
      摘要:Negative thermal expansion (NTE) matrices offer an effective strategy to suppress thermal quenching of rare-earth luminescence for high-sensitivity optical thermometry. Herein, a series of NTE Sc2Mo3O12∶xDy3+ phosphors were synthesized via solid-state reaction. Rietveld refinement confirms pure orthorhombic phase (Pbcn) with Dy3+ occupying Sc3+ sites. Under 468 nm excitation, the phosphors exhibit characteristic Dy3+ yellow emission with tunable color from yellow to yellow-green. Benefiting from the NTE host and thermally activated [MoO42-→Dy3+ energy transfer, an anomalous negative thermal quenching is observed (303~393 K), where emission intensity increases with temperature. Based on this characteristic, we constructed two luminescence intensity ratio (LIR) thermometric modes: a single-emission-center non-thermally coupled mode (with absolute sensitivity Sa=12%·K-1 and relative sensitivity Sr=0.45%·K-1 at 513 K) and a dual-excitation non-thermally coupled mode (with Sa=1.38%·K-1 and Sr=0.77%·K-1 at 513 K).The material exhibits excellent thermal cycling reversibility. Integrating NTE synergy, anomalous thermal enhancement, and high sensitivity, Sc2Mo3O12∶xDy3+ shows great promise for high-temperature optical thermometry.  
      关键词:Sc2Mo3O12;Dy3+;negative thermal quenching;negative thermal expansion;optical thermometry;luminescence intensity ratio (LIR)   
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    • LU Jinling, HUO Youhe, ZHANG Ping, CHEN Lei, WANG Weiguo, CAO Shuyao
      Vol. 47, Issue 6, Pages: 1008-1017(2026) DOI: 10.37188/CJL.20260047
      摘要:Due to the inherent chromogenic response limitation, the further development of conventional photochromic materials in applications such as multi-dimensional information storage and dynamic anti-counterfeiting has been restricted. To address the issue of monotonous photochromism in KSr2Nb5O15-based ceramics, this work proposes a structural tuning strategy via A-site cation modification. The KSr2+xNb5O15+δ ceramic system was prepared by tuning the K+/Sr2+ ratio, and the effects of Sr2+ content variations on the microstructures and photochromic properties of samples were systematically investigated. The results reveal that Sr2+ content significantly influenced the crystal lattice structure, oxygen vacancy concentration, and trap distribution, thereby modulating the environmental size around the color centers. By increasing the Sr2+ content, the sizes around photochromic color centers were regulated, and the characteristic light absorption in red spectral range(550 nm to 750 nm) was significantly enhanced after photochromic reaction, enabling controlled modulation of the photochromic behavior. This work proposed a novel approach and experimental foundation for modulating the properties of inorganic photochromic materials.  
      关键词:photochromic;ceramics;KSr2Nb5O15   
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    • TU Qisheng, LIN Qiuxiang, WANG Jianbin, TANG Xiaosheng
      Vol. 47, Issue 6, Pages: 1018-1028(2026) DOI: 10.37188/CJL.20260037
      摘要:Side-chain fluorination of non-fullerene acceptors (NFAs) has rarely been reported to enhance the performance of organic solar cells, despite its critical role in boosting the carrier mobility property. Three acceptor-donor-acceptor (A-D-A) type acceptors (HP1, HP2, and HP3) based on dithienocyclopentacarbazole are successfully designed and synthesized. The effects of fluorinations in side-chains and ending groups on the final photovoltaic performance are investigated in detail. Compared to HP2 with fluorinated side-chains, HP1 with fluorinated ending groups shows red-shifted absorption and down-shifted energy levels. For HP3 with fluorination in both side-chains and ending groups, the lowest unoccupied molecular orbital (LUMO) energy level is up-shifted to -3.88 eV in spite of its slightly enlarged optical bandgap in comparison with that of HP1. The PM6∶HP3 blend presents better morphology and carrier transport property than HP1- and HP2-based counterparts, and thereby leading to an increased power conversion efficiency (PCE) of 11.48% with an open-circuit voltage (Voc) of 0.97 V for the corresponding device. However, the HP1-based device delivers a decreased PCE of 11.08% with a reduced Voc of 0.93 V. And, the PCE based on PM6∶HP2 blend is only 4.20%. It should be noted that the organic solar cells based on PM6∶HP1∶HP3 (1∶0.5∶0.5, w/w/w) affords an enhanced PCE of 11.95%. The findings indicate that rational fluorinated side-chain engineering can significantly enhance the photovoltaic performance of NFAs.  
      关键词:Non-fullerene acceptor;organic solar cell;Dithienocyclopentacarbazole;Fluorinated side-chain;power conversion efficiency   
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      Device Fabrication and Physics

    • LIANG Weilong, SUN Xinyu, DAI Jia, WANG Li, LUO Linbao, ZHANG Xiang
      Vol. 47, Issue 6, Pages: 1029-1042(2026) DOI: 10.37188/CJL.20260045
      摘要:Organic/quantum dot infrared up-conversion devices electrically couple an infrared photodetecting unit with a visible light-emitting unit, enabling direct translation of invisible infrared information into visible emission for real-time visualization and imaging. Compared with conventional infrared imaging technologies that rely on epitaxial detector arrays integrated with readout circuits, up-conversion devices avoid pixel-level hybrid interconnection as well as the associated readout electronics and algorithmic processing, offering a simplified system architecture and a more cost-effective manufacturing route. Owing to their excellent process compatibility and readily tunable bandgaps, organic semiconductors and colloidal quantum dots provide a versatile materials platform for constructing low-cost, large-area infrared up-conversion devices. This review summarizes recent advances in organic/quantum dot infrared up-conversion devices from a fabrication perspective. Focusing on vacuum thermal evaporation, solution processing, and hybrid integration strategies, we highlight representative progress in materials development, device architecture engineering, and application demonstrations. Finally, we discuss future directions and remaining challenges toward higher upconversion efficiency and broader spectral extension.  
      关键词:organic/quantum dot;infrared up-conversion device;light-emitting diode   
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    • High-power, Single-mode 976 nm Diode Laser with Ultra-low Divergence Angle 增强出版 AI导读

      PANG Zheng, WANG Lijie, LIU Yanan, WANG Yanjing, LU Huanyu, JI Yunfei, ZHENG Xianda, WANG Yushan, XUE Xiaoe, TIAN Sicong, MENG Bo, TONG Cunzhu
      Vol. 47, Issue 6, Pages: 1043-1051(2026) DOI: 10.37188/CJL.20260053
      摘要:Erbium-doped fiber amplifiers (EDFAs) serve as key component of high-capacity, all-optical communication networks, relying critically on high-power, single-mode diode laser pumping sources to achieve efficient optical signal amplification. This paper reports a high-power 976 nm single-mode diode laser chip. The device utilizes an asymmetric Bragg reflector waveguide epitaxial structure, achieving an ultra-low far-field divergence angle and a nearly circular beam profile. Experimental results demonstrate a maximum continuous-wave (CW) output power exceeding 1.5 W for the laser, limited by thermal saturation. The kink-free output power reaches 0.83 W at an injection current of 1.2 A. At this operating current, the vertical and lateral divergence angles containing 95% power are measured at 13.70° and 10.95° respectively. The laser emits at a peak wavelength of 976.16 nm with a narrow spectral width of 0.11 nm (at -3 dB) and a side-mode suppression ratio (SMSR) of 40 dB. The far-field distribution remains stable by varying heat-sink temperature and current. Even under thermal saturation, the vertical divergence angle (defined at 95% power containment) stays below 16°. Owing to its high output power, circular symmetry, and narrow spectral characteristics, this laser chip is conducive to the development of low-cost, high-power single-mode pump modules for EDFAs.  
      关键词:Bragg reflection waveguide;single-mode diode laser;high-power;low far-field divergence angle;fiber coupling   
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    • CAI Junhao, LI Mingda, PEI Hao, XING Tinglun
      Vol. 47, Issue 6, Pages: 1052-1059(2026) DOI: 10.37188/CJL.20250293
      摘要:The vanadium diselenide (VSe2) powder was synthesized via a hydrothermal method, and a reflective VSe2 saturable absorber mirror was fabricated using liquid-phase exfoliation combined with a spin-coating process. Nonlinear optical characterization was performed using the open-aperture Z-scan technique at 1.06 μm and 3 μm, yielding modulation depths of approximately 6.1% and 4.9%, respectively. The results demonstrate that the VSe2 thin film exhibits broadband saturable absorption properties. To investigate its applicability as a passive fast photonic switch, the VSe2 saturable absorber was integrated into an end-pumped Er∶YAP laser system operating at 2.8 μm, achieving stable passive Q-switched laser output. A stable pulse train emerged when the pump power reached 3.3 W, with an average output power of approximately 0.1 W. At a pump power of 7.3 W, the average output power increased to around 0.56 W, corresponding to an optical-to-optical conversion efficiency of approximately 11.4%. Under this condition, the pulsed laser had a repetition rate of 199.9 kHz and a pulse width of 208.6 ns. These findings indicate that the broadband VSe2 saturable absorber serves as an effective photonic modulator in the 1 μm to 3 μm wavelength range for achieving stable passive Q-switched laser operation, while also laying the foundation for realizing passive mode-locking in the mid-infrared spectral region.  
      关键词:mid-infrared;optical switching devices;broadband saturable absorber;Q-switched;Er∶YAP   
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      Luminescence Industry and Technology Frontier

    • LU Lihong, ZHANG Lele, XU Jian
      Vol. 47, Issue 6, Pages: 1060-1069(2026) DOI: 10.37188/CJL.20260022
      摘要:With the low-altitude economy established as a strategic emerging industry in China, its scale has expanded rapidly, driving iteration in core technologies. Aviation obstruction lights, as critical safety infrastructure in architecture and civil engineering, are installed atop tall structures to warn aircraft, prevent collisions, and ensure orderly low-altitude operations. These lights function as high-intensity projectors requiring precise optical distribution. Laser illumination technology, characterized by high brightness, low divergence, and compact structure, offers superior beam control and intensity over traditional light sources. Furthermore, the niche nature of the aviation lighting market reduces price sensitivity, which helps mitigate the cost disadvantage of lasers and opens new opportunities for the industry. Against this backdrop, this article first reviews the technological evolution of obstruction lighting, then interprets key parameters in current Chinese civil aviation standards and summarizes their requirements for luminous materials and light sources. Subsequently, it details the physical principles underlying the significant advantages of laser lighting in this application. Finally, from an industry perspective, it outlines future trends and challenges, offering insights for researchers in the field.  
      关键词:Low-altitude Economy;Aviation Obstruction Lights;laser lighting   
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      Luminescence Applications and Interdisciplinary Fields

    • CHEN Yi, HU Yi
      Vol. 47, Issue 6, Pages: 1070-1079(2026) DOI: 10.37188/CJL.20260059
      摘要:A multicomponent synergistically optimized poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)-based stretchable alternating-current electroluminescent (ACEL) fiber device was fabricated using coaxial conjugated electrospinning. The effects of doping concentrations of barium titanate (BaTiO3), polydimethylsiloxane (PDMS), and a rheological additive (RA-8410) on the dielectric properties, mechanical behavior, and particle suspension stability of the emissive layer were systematically investigated. The results demonstrate that the incorporation of BaTiO3 effectively enhances the local electric field by increasing the dielectric constant; PDMS significantly decreases the Young’s modulus and induces the formation of the electroactive β-phase; and RA-8410 resolves the particle sedimentation dilemma by constructing a physical thixotropic network. The comprehensive performance of the emissive layer is maximized at a BaTiO3/PVDF-HFP mass ratio of 1∶6, with mass fraction 20% PDMS and 5% RA-8410. Under these optimal conditions, the as-fabricated stretchable ACEL fibers successfully break the inherent trade-off between mechanical compliance and luminescent performance, delivering a reliable luminance of 56.64 cd·m-2 under 200 Vrms and 6 kHz driving field while withstanding a 100% tensile strain. This research provides a highly feasible paradigm for the continuous and scalable fabrication of smart wearable display devices.  
      关键词:alternating-current electroluminescent fiber;conjugated electrospinning;rheological additive;flexible display device   
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    • GAO Yanhao, ZHOU Lixiang, ZHANG Ligong, JING Pengtao, LUO Jinsong
      Vol. 47, Issue 6, Pages: 1080-1089(2026) DOI: 10.37188/CJL.20260029
      摘要:Raman spectroscopy technology has significant advantages in identifying the composition and structural characteristics of biological tissues due to its high specificity, insensitivity to moisture, and non-destructive testing. This study preliminarily explores the application of Raman spectroscopy analysis in identifying differences in cellular states within brain tissues affected by severe traumatic brain injury. Raman spectroscopy was employed to obtain Raman spectral information through point‑by‑point detection of pathological tissue specimens from normal, edematous, and necrotic areas at the margins of damaged brain tissue resected intraoperatively from a patient with severe traumatic brain injury treated in neurotrauma surgery. The Raman spectral data collected from different sampling points were compared in terms of peak shape structure and peak intensity. This research provides valuable information for the potential application of Raman spectroscopy in distinguishing boundaries between injured and normal brain tissue, and demonstrates its promise as an intraoperative rapid diagnostic technique to guide surgical treatment.  
      关键词:traumatic brain injury tissue;Raman spectroscopy;spectral analysis   
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    • XING Huan, LI Xinping, ZHANG Zhao, BAO Guochen, LUO Yuxia
      Vol. 47, Issue 6, Pages: 1090-1099(2026) DOI: 10.37188/CJL.20260068
      摘要:Thiol compounds are key molecules for homeostatic regulation and environmental monitoring within biological systems. The development of rapid and highly sensitive thiol detection methods holds significant importance for early disease diagnosis and environmental risk management. Fluorescent probes, owing to their high selectivity, high sensitivity, and non-invasive nature, have emerged as critical tools for detecting bio-small molecules, metal ions, and anions. This study employs IR806-sensitized upconversion nanoparticles (IR806-UCNP) as the core fluorescent probe system. By modifying the UCNP surface with polyethyleneimine (PEI), the probe’s dispersibility and biocompatibility were effectively enhanced, conferring good hydrophilicity and stability in aqueous environments. Building upon this, the specific nucleophilic substitution reaction between thiol molecules and particular active groups in the IR806 dye was utilized to achieve specific fluorescence signal response of the probe to thiol molecules. This IR806-UCNP upconversion fluorescent probe, excited by near-infrared light, enables rapid and highly sensitive detection of thiol compounds. It exhibits a low detection limit of 0.1 μmol/L for glutathione(GSH), a typical thiol molecule in biological systems, providing a reliable method for subsequent applications in bioanalysis or environmental monitoring.  
      关键词:upconversion;fluorescent probe;near-infrared;Thiol Detection   
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    • ZHANG Lei, DAI Yonglian, WU Yulin, JIA Hongmin, SHANG Zhuye, MENG Qingtao
      Vol. 47, Issue 6, Pages: 1100-1108(2026) DOI: 10.37188/CJL.20260026
      摘要:Biothiols (Cys, GSH, and Hcy) are thiol-containing small molecules with relatively high abundance in organisms, and the imbalance of their homeostasis is closely associated with various diseases. Therefore, developing a detection method for biothiols with high sensitivity, high selectivity, and rapid response is particularly crucial for disease monitoring. In this study, a triphenylamine-based near-infrared fluorescent probe P11 for biothiols was constructed using triphenylamine as the electron donor group, 1,3-indanedione as the electron acceptor unit, and electron-deficient C̿    C double bonds as the recognition sites. The Michael addition reaction between the thiol group of biothiols and the electron-deficient C̿    C double bonds results in the fluorescence quenching of the probe. Probe P11 exhibits multiple advantages, such as near-infrared emission (690 nm), rapid response (60 s), and a large Stokes shift (215 nm). The detection limits (LODs) for Cys, GSH, and Hcy are as low as 33.9 μmol/L, 29.0 μmol/L, and 34.3 μmol/L, respectively. Probe P11 has successfully achieved fluorescent imaging of exogenous and endogenous biothiols in mice, providing an effective tool for the diagnosis of biothiol-related diseases and in vivo imaging research.  
      关键词:fluorescent probe;Biothiols;near infrared;triphenylamine;bioimaging   
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      更新时间:2026-06-24
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