Design of NIR-Ⅱ Luminescent Materials and Applications in Brain Imaging

XUE Dongzhi; WANG Yinghui; ZHANG Hongjie

doi:10.37188/CJL.20230122

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Design of NIR-Ⅱ Luminescent Materials and Applications in Brain Imaging

Invited Paper | 更新时间：2023-08-02

- Design of NIR-Ⅱ Luminescent Materials and Applications in Brain Imaging
  增强出版
- Chinese Journal of Luminescence Vol. 44, Issue 7, Pages: 1131-1148(2023)
- 作者机构：
  
  1.中国科学院长春应用化学研究所稀土资源利用国家重点实验室，吉林长春　130022
  2.中国科学技术大学应用化学与工程学院，安徽合肥　230026
  3.清华大学化学系，北京　100084
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China(22020102003;52022094;52272169);the Program of Science and Technology Development Plan of Jilin Province of China(20210101111JC)
- DOI：10.37188/CJL.20230122
  CLC：
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薛东芝,王樱蕙,张洪杰.近红外二区发光材料在脑成像中的研究进展[J].发光学报,2023,44(07):1131-1148.

XUE Dongzhi,WANG Yinghui,ZHANG Hongjie.Design of NIR-Ⅱ Luminescent Materials and Applications in Brain Imaging[J].Chinese Journal of Luminescence,2023,44(07):1131-1148.
薛东芝,王樱蕙,张洪杰.近红外二区发光材料在脑成像中的研究进展[J].发光学报,2023,44(07):1131-1148. DOI： 10.37188/CJL.20230122.

XUE Dongzhi,WANG Yinghui,ZHANG Hongjie.Design of NIR-Ⅱ Luminescent Materials and Applications in Brain Imaging[J].Chinese Journal of Luminescence,2023,44(07):1131-1148. DOI： 10.37188/CJL.20230122.

摘要

目前，荧光成像技术已成为生物医学应用中的重要工具之一，但其易受到光的穿透能力有限、组织自体荧光干扰等因素的影响。与可见光和近红外一区（NIR⁃Ⅰ）光相比，近红外二区（NIR⁃Ⅱ）荧光成像具有更深的穿透深度、更高的成像分辨率和灵敏度、更低的背景噪音和更高的信噪比，因此在脑血管成像和重大脑疾病的成像诊断方面展现出潜在的应用前景。本文主要介绍了不同类型NIR⁃Ⅱ荧光探针及优化其光学性能的策略。同时，总结了这些探针在脑成像方面的研究进展，并对未来临床应用所面临的问题进行了探讨。

Abstract

At present， fluorescence imaging has become one of the important tools in biomedical applications， but it is very susceptible to the limited penetration of light and auto-fluorescence in tissues. Compared with the fluorescence imaging in visible region and the first near-infrared window（NIR-Ⅰ）， the second near-infrared（NIR-Ⅱ） fluorescence imaging show the deeper penetration depth， lower background noise， higher imaging resolution， sensitivity， and signal-to-noise ratio， thus demonstrating the promising applications in cerebrovascular imaging and diagnosis of major brain diseases. Based on this， we mainly focus on the construction of different NIR-Ⅱ fluorescent probes and several strategies to optimize their optical performance. Meanwhile， the recent progress of these probes in brain imaging is summarized and some issues facing the future clinical applications are discussed.

关键词

荧光成像近红外二区荧光探针脑疾病

Keywords

fluorescence imagingNIR-Ⅱfluorescence probebrain diseases

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