Research Progress of Photodynamic Therapy Based on Porphyrin-metal Organic Framework Materials

KONG Qingchao; SUN Wenyue; LIN Jinying; WANG Lin; DONG Biao

doi:10.37188/CJL.20230097

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Research Progress of Photodynamic Therapy Based on Porphyrin-metal Organic Framework Materials

Luminescence Applications and Interdisciplinary Fields | 更新时间：2023-09-06

- Research Progress of Photodynamic Therapy Based on Porphyrin-metal Organic Framework Materials
  增强出版
- Chinese Journal of Luminescence Vol. 44, Issue 8, Pages: 1505-1519(2023)
- 作者机构：
  
  1.吉林大学口腔医学院，吉林长春　130021
  2.吉林大学电子科学与工程学院，集成光电子学国家重点实验室，吉林长春　130012
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China(52272080;52250077)
- DOI：10.37188/CJL.20230097
  CLC： O482.31
- Published：05 August 2023，
  
  Received：15 April 2023，
  
  Revised：27 April 2023，
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孔庆超,孙文悦,林金莹等.基于卟啉⁃金属有机框架材料的光动力疗法研究进展[J].发光学报,2023,44(08):1505-1519.

KONG Qingchao,SUN Wenyue,LIN Jinying,et al.Research Progress of Photodynamic Therapy Based on Porphyrin-metal Organic Framework Materials[J].Chinese Journal of Luminescence,2023,44(08):1505-1519.
孔庆超,孙文悦,林金莹等.基于卟啉⁃金属有机框架材料的光动力疗法研究进展[J].发光学报,2023,44(08):1505-1519. DOI： 10.37188/CJL.20230097.

KONG Qingchao,SUN Wenyue,LIN Jinying,et al.Research Progress of Photodynamic Therapy Based on Porphyrin-metal Organic Framework Materials[J].Chinese Journal of Luminescence,2023,44(08):1505-1519. DOI： 10.37188/CJL.20230097.

摘要

卟啉⁃金属有机框架（MOFs）材料是由金属节点和卟啉有机配体构成的一类新型多孔材料，MOFs骨架上的卟啉配体在光激发下，可以发挥光动力学治疗（PDT）作用。这类多孔结构的PDT材料在疾病治疗中，可以发挥载药、多功能修饰等功能，某些金属位点独特的MOFs还具有纳米酶功能。近年来，这类卟啉⁃MOFs已经成为PDT领域的重要研究方向。目前，在推向临床前，这类材料还需要解决氧气浓度、能量传递效率等问题，研究者也给出了诸多解决方案，根据实际应用过程中所面对的不同环境，采取不同手段来增强PDT的效果，包括提高氧气浓度、改进能量传递过程、消耗功能分子、产生信号分子以及协同策略等。本文综述了近年来的代表性工作，包括卟啉⁃MOFs材料以及PDT产生的机制，卟啉⁃MOFs材料PDT的应用和最新进展，并针对卟啉⁃MOFs材料的PDT在生物医学领域未来发展趋势进行了展望。

Abstract

Porphyrin-metal-organic frameworks （MOFs） materials are a new class of porous materials composed of metal nodes and porphyrin organic ligands. The porphyrin ligands on the MOFs can exert photodynamic therapy （PDT） under light excitation. This kind of PDT material with porous structure can play the functions of drug loading and multifunctional modification in the treatment of diseases. Some MOFs with unique metal sites also have the function of nanozymes. In recent years， this kind of porphyrin-MOFs has become an important research direction in the field of PDT. At present， such materials need to solve problems such as oxygen concentration and energy transfer efficiency before being promoted to the clinic. Researchers have also given many solutions， and adopt different methods to enhance PDT according to different environments faced in the actual application process， including increasing oxygen concentration， improving the energy transfer process， consumption of functional molecules， generation of signal molecules and synergistic strategies. This paper reviews the representative work in recent years， including porphyrin-MOFs materials and the mechanism of PDT generation， the application and latest progress of PDT of porphyrin-MOFs materials. Finally， the future development trend of PDT for porphyrin-MOFs materials in the field of biomedicine has prospected.

关键词

卟啉金属有机框架光动力疗法

Keywords

porphyrinsmetal-organic frameworksphotodynamic therapy

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College of Electronic Science and Engineering， Jilin University， State Key Laboratory on Integrated Optoelectronics

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Institute of Flexible Electronics， Northwestern Polytechnical University

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