Research Progress of Stimuli-responsive AIE-active Hydrogels

Xue-fei WEN; Ren SHA; Jian-guo WANG

doi:10.37188/CJL.20220023

您当前的位置：

首页 >

文章列表页 >

Research Progress of Stimuli-responsive AIE-active Hydrogels

Invited Review | 更新时间：2022-05-23

- Research Progress of Stimuli-responsive AIE-active Hydrogels
  增强出版
- Chinese Journal of Luminescence Vol. 43, Issue 5, Pages: 642-661(2022)
- 作者机构：
  
  1.内蒙古师范大学　化学与环境科学学院，内蒙古　呼和浩特　010022
  2.内蒙古大学　化学化工学院，内蒙古精细有机合成重点实验室，内蒙古　呼和浩特　010021
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China(22165020;22161034;21871060);Grassland Talent Program of Inner Mongolia Autonomous Region of China;Science and Technology Program of Inner Mongolia(2021GG0154);the Natural Science Foundation of Inner Mongolia Autonomous Region of China(2020JQ02;2020MS02004);Young Science and Technology Talents Cultivation Project of Inner Mongolia University(21221505);the Natural Science Foundation of Jiangxi Province(20192BCBL23013)
- DOI：10.37188/CJL.20220023
  CLC： O482.31
- Published：2022-05，
  
  Received：17 January 2022，
  
  Revised：04 February 2022，
扫描看全文
Xue-fei WEN, Ren SHA, Jian-guo WANG. Research Progress of Stimuli-responsive AIE-active Hydrogels. [J]. Chinese Journal of Luminescence 43(5):642-661(2022)
DOI：

Xue-fei WEN, Ren SHA, Jian-guo WANG. Research Progress of Stimuli-responsive AIE-active Hydrogels. [J]. Chinese Journal of Luminescence 43(5):642-661(2022) DOI： 10.37188/CJL.20220023.

摘要

刺激响应水凝胶可以对环境的微小变化产生较大的物理化学变化，在药物传递、生物分离、生物传感器和组织工程等领域具有广泛的应用。但受聚集导致荧光猝灭（ACQ）效应的影响，其在发光相关领域的应用受到限制，聚集诱导发光（AIE）概念的提出解决了这一难题。将AIE分子引入水凝胶体系，获得刺激响应型AIE水凝胶，在生物医学、信息防伪、3D水凝胶驱动器以及软体机器人的开发等多个高科技领域崭露头角。本文将近年来报道的刺激响应型AIE水凝胶按刺激因素分为物理因素（温度和光）、化学因素（pH、溶剂和离子）和生物因素（酶）三大类，分别阐述了水凝胶的制备、响应机理及潜在应用，并针对刺激响应型AIE水凝胶面临的问题和挑战进行了展望。

Abstract

Stimulus-responsive hydrogels

which can undergo physical and/or chemical changes in response to the minor variations in the environment

are widely applied in the fields of drug delivery

bioseparation

biosensors and tissue engineering. However

due to the aggregation-caused quenching(ACQ) of fluorescence

their applications in luminescence-related fields are extremely limited. Fortunately

aggregation-induced emission(AIE) phenomena perfectly resolved the problem. By incorporating fluorophores with AIE feature into hydrogels

stimuli-responsive AIE-active hydrogels can be obtained. And they have cut a figure in several high-tech fields including biomedical

information anti-counterfeiting

3D hydrogel actuators and soft robots. In this article

we summarized and classified the recently reported stimuli-responsive AIE-active hydrogels into three categories: those are responsive to physical(temperature and light)

chemical(pH

solvent and ion type) and biological(enzyme) stimulus. The preparation

responsive mechanism and applications of these stimuli-responsive AIE-active hydrogels were described respectively. And finally

the problems and challenges faced by stimuli-responsive AIE-active hydrogels are also prospected.

关键词

刺激响应型水凝胶聚集诱导发光信息防伪软体机器人药物传递

Keywords

stimuli-responsive hydrogelsaggregation-induced emissioninformation anti-counterfeitingsoft robotsdrug delivery

references

GHOBRIL C, GRINSTAFF M W. The chemistry and engineering of polymeric hydrogel adhesives for wound closure: a tutorial[J]. Chem. Soc. Rev., 2015, 44(7): 1820-1835.

LIU W, ZHANG W S, YU X Q, et al. Synthesis and biomedical applications of fluorescent nanogels[J]. Polym. Chem., 2016, 7(37): 5749-5762.

RAMAN R, LANGER R. Biohybrid design gets personal:new materials for patient-specific therapy[J]. Adv. Mater., 2020, 32(13): 1901969-1-19.

LEE S C, KWON I K, PARK K. Hydrogels for delivery of bioactive agents:a historical perspective[J]. Adv. Drug. Deliv. Rev., 2013, 65(1): 17-20.

HE C L, KIM S W, LEE D S. In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery[J]. J. Control. Release, 2008, 127(3): 189-207.

MEI J, LEUNG N L C, KWOK R T K, et al. Aggregation-induced emission:together we shine, united we soar![J]. Chem. Rev., 2015, 115(21): 11718-11940.

LUO J D, XIE Z L, LAM J W Y, et al. Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole[J]. Chem. Commun., 2001, (18): 1740-1741.

秦安军, 胡蓉. 聚集诱导发光聚合物的机遇与挑战：聚合物之美与聚集体之光相辉映[J]. 发光学报, 2020, 41(9): 1082-1086.

QIN A J, HU R. Prospect and challenge of polymers featuring aggregation-induced emission characteristics[J]. Chin. J. Lumin., 2020, 41(9): 1082-1086. (in Chinese)

彭嘉琪, 陈明, 秦安军, 等. 聚集诱导发光探针用于线粒体靶向和癌细胞识别研究进展[J]. 发光学报, 2021, 42(3): 348-360.

PENG J Q, CHEN M, QIN A J, et al. Progress on aggregation-induced emission probes for mitochondria target and cancer cell identification[J]. Chin. J. Lumin., 2021, 42(3): 348-360. (in Chinese)

WANG T, YIN P, YANG Y, et al. Effect of element iodine on the cell membrane transportability of fluorescent polymers and lysosome-targeted cell imaging[J]. ACS Sustainable Chem. Eng., 2019, 7(6): 6295-6303.

MA H C, QI C X, CHENG C, et al. AIE-active tetraphenylethylene cross-linked N-isopropylacrylamide polymer:a long-term fluorescent cellular tracker[J]. ACS Appl. Mater. Interfaces, 2016, 8(13): 8341-8348.

ZHANG S X, YIN W D, YANG Z M, et al. Functional copolymers married with lanthanide(Ⅲ) ions:a win-win pathway to fabricate rare earth fluorescent materials with multiple applications[J]. ACS Appl. Mater. Interfaces, 2021, 13(4): 5539-5550.

YANG Y, WANG T, YIN P, et al. A general concept for white light emission formation from two complementary colored luminescent dyes[J]. Mater. Chem. Front., 2019, 3(3): 505-512.

LI J, WANG J X, LI H X, et al. Supramolecular materials based on AIE luminogens(AIEgens):construction and applications[J]. Chem. Soc. Rev., 2020, 49(4): 1144-1172.

WANG H Y, HEILSHORN S C. Adaptable hydrogel networks with reversible linkages for tissue engineering[J]. Adv. Mater., 2015, 27(25): 3717-3736.

WU D Y, MEURE S, SOLOMON D. Self-healing polymeric materials:a review of recent developments[J]. Prog. Polym. Sci., 2008, 33(5): 479-522.

HILLEWAERE X K D, PREZ F E D. Fifteen chemistries for autonomous external self-healing polymers and composites[J]. Prog. Polym. Sci., 2015, 49-50: 121-153.

HOU F J, XI B Z, WANG X M, et al. Self-healing hydrogel with cross-linking induced thermo-response regulated light emission property[J]. Colloids Surf. B: Biointerfaces, 2019, 183: 110441-1-10.

GUILLOU O, DAIGUEBONNE C, CALVEZ G, et al. A long journey in lanthanide chemistry:from fundamental crystallogenesis studies to commercial anticounterfeiting taggants[J]. Acc. Chem. Res., 2016, 49(5): 844-856.

TIAN W G, ZHANG J M, YU J, et al. Phototunable full-color emission of cellulose-based dynamic fluorescent materials[J]. Adv. Funct. Mater., 2018, 28(9): 1703548-1-8.

SHI C, SHEN X Y, ZHU Y A, et al. Excitation wavelength-dependent dual-mode luminescence emission for dynamic multicolor anticounterfeiting[J]. ACS Appl. Mater. Interfaces, 2019, 11(20): 18548-18554.

MA Y, DONG Y F, LIU S Y, et al. Chameleon-like thermochromic luminescent materials with controllable response behaviors for multilevel security printing[J]. Adv. Opt. Mater., 2020, 8(6): 1901687-1-6.

LIU Y J, LEE Y H, LEE M R, et al. Flexible three-dimensional anticounterfeiting plasmonic security labels:utilizing Z-axis-dependent SERS readouts to encode multilayered molecular information[J]. ACS Photonics, 2017, 4(10): 2529-2536.

HU L, ZHANG Q, LI X, et al. Stimuli-responsive polymers for sensing and actuation[J]. Mater. Horiz., 2019, 6(9): 1774-1793.

YUK H, LU B Y, ZHAO X H. Hydrogel bioelectronics[J]. Chem. Soc. Rev., 2019, 48(6): 1642-1667.

ZHU C N, BAI T W, WANG H, et al. Single chromophore-based white-light-emitting hydrogel with tunable fluorescence and patternability[J]. ACS Appl. Mater. Interfaces, 2018, 10(45): 39343-39352.

ZHU Q D, VAN VLIET K, HOLTEN-ANDERSEN N, et al. A double-layer mechanochromic hydrogel with multidirectional force sensing and encryption capability[J]. Adv. Funct. Mater., 2019, 29(14): 1808191-1-8.

HAI J, WANG H, SUN P P, et al. Smart responsive luminescent aptamer-functionalized covalent organic framework hydrogel for high-resolution visualization and security protection of latent fingerprints[J]. ACS Appl. Mater. Interfaces, 2019, 11(47): 44664-44672.

KANG H S, HAN S W, PARK C, et al. 3D touchless multiorder reflection structural color sensing display[J]. Sci. Adv., 2020, 6(30): eabb5769-1-10.

QIU H Y, WEI S X, LIU H, et al. Programming multistate aggregation-induced emissive polymeric hydrogel into 3D structures for on-demand information decryption and transmission[J]. Adv. Intell. Syst., 2021, 3(6): 2000239-1-9.

HU Y B, BARBIER L, LI Z, et al. Hydrophilicity-hydrophobicity transformation, thermoresponsive morphomechanics, and crack multifurcation revealed by AIEgens in mechanically strong hydrogels[J]. Adv. Mater., 2021, 33(39): 2101500-1-11.

HESKINS M, GUILLET J E. Solution properties of poly(N-isopropylacrylamide)[J]. J. Macromol. Sci.: Part A-Chem., 1968, 2(8): 1441-1455.

KIM H J, LEE H J, CHUNG J W, et al. A highly fluorescent and photoresponsive polymer gel consisting of poly(acrylic acid) and supramolecular cyanostilbene crosslinkers[J]. Adv. Opt. Mater., 2019, 7(4): 1801348-1-7.

DING Z Y, MA Y, SHANG H X, et al. Fluorescence regulation and photoresponsivity in AIEE supramolecular gels based on a cyanostilbene modified benzene-1,3,5-tricarboxamide derivative[J]. Chem. -Eur. J, 2019, 25(1): 315-322.

ZHAO Y, SHI C, YANG X D, et al. pH- and temperature-sensitive hydrogel nanoparticles with dual photoluminescence for bioprobes[J]. ACS Nano, 2016, 10(6): 5856-5863.

LI Z, LIU P C, JI X F, et al. Bioinspired simultaneous changes in fluorescence color, brightness, and shape of hydrogels enabled by AIEgens[J]. Adv. Mater., 2020, 32(11): 1906493-1-10.

RICHARDSON F S, RIEHL J P. Circularly polarized luminescence spectroscopy[J]. Chem. Rev., 1977, 77(6): 773-792.

MAEDA H, BANDO Y, SHIMOMURA K, et al. Chemical-stimuli-controllable circularly polarized luminescence from anion-responsive π-conjugated molecules[J]. J. Am. Chem. Soc., 2011, 133(24): 9266-9269.

WU S T, CAI Z W, YE Q Y, et al. Enantioselective synthesis of a chiral coordination polymer with circularly polarized visible laser[J]. Angew. Chem. Int. Ed., 2014, 53(47): 12860-12864.

NIU D, JIANG Y Q, JI L K, et al. Self-assembly through coordination and π-stacking:controlled switching of circularly polarized luminescence[J]. Angew. Chem. Int. Ed., 2019, 58(18): 5946-5950.

SHANG H X, DING Z Y, SHEN Y, et al. Multi-color tunable circularly polarized luminescence in one single AIE system[J]. Chem. Sci., 2020, 11(8): 2169-2174.

WU S S, SHI H H, LU W, et al. Aggregation-induced emissive carbon dots gels for octopus-inspired shape/color synergistically adjustable actuators[J]. Angew. Chem. Int. Ed., 2021, 60(40): 21890-21898.

YAN C, KRAMER P L, YUAN R F, et al. Water dynamics in polyacrylamide hydrogels[J]. J. Am. Chem. Soc., 2018, 140(30): 9466-9477.

SHI B B, LIU Y Z, ZHU H T Z, et al. Spontaneous formation of a cross-linked supramolecular polymer both in the solid state and in solution, driven by platinum(Ⅱ) metallacycle-based host-guest interactions[J]. J. Am. Chem. Soc., 2019, 141(16): 6494-6498.

WANG Z F, AN G, ZHU Y, et al. 3D-printable self-healing and mechanically reinforced hydrogels with host-guest non-covalent interactions integrated into covalently linked networks[J]. Mater. Horiz., 2019, 6(4): 733-742.

YANG H L, ZHANG Q P, ZHANG Y M, et al. A novel strong AIE bi-component hydrogel as a multi-functional supramolecular fluorescent material[J]. Dyes Pigm., 2019, 171: 107745-1-8.

ZHAO Q, DAI X Y, YAO H, et al. Stimuli-responsive supramolecular hydrogel with white AIE effect for ultrasensitive detection of Fe3+ and as rewritable fluorescent materials[J]. Dyes Pigm., 2021, 184: 108875-1-9.

JIANG H, QIN Z J, ZHENG Y K, et al. Aggregation-induced electrochemiluminescence by metal-binding protein responsive hydrogel scaffolds[J]. Small, 2019, 15(18): 1901170-1-8.

WANG H, JI X F, LI Y, et al. An ATP/ATPase responsive supramolecular fluorescent hydrogel constructed via electro-static interactions between poly(sodium p-styrenesulfonate) and a tetraphenylethene derivative[J]. J. Mater. Chem. B, 2018, 6(18): 2728-2733.

JI X F, LI Z, LIU X L, et al. A functioning macroscopic “Rubik's Cube” assembled via controllable dynamic covalent interactions[J]. Adv. Mater., 2019, 31(40): 1902365-1-8.

Views

338

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

CJL | Rising star in materials: stimulus-responsive AIE hydrogel

Conjugated Materials Containing Ethyl Benzoate Structure for Fluorescent Detection of Nitroaromatic Explosives

Synthesis and Characterization of Aggregation-induced Red Emitter Based on Dibenzophenazine Core

Application of NIR-Ⅱ Aggregation Induced Emission Materials in Surgical Navigation

Application of Tetraphenylene Aggregation-induced Emission Probes in Field of Biomolecular Detection

Related Author

Xuefei WEN

Ren SHA

Jianguo WANG

YANG Cheng

HU Xin

TAO Tao

XING Yifan

SHI Mingkai

Related Institution

College of Chemistry and Chemical Engineering， Inner Mongolia Key Laboratory of Fine Organic Synthesis， Inner Mongolia University

College of Chemistry and Environmental Science， Inner Mongolia Normal University

School of Chemistry and Materials Science， Nanjing University of Information Science & Technology

Key Laboratory of Interface Science and Engineering in Advanced Materials， Ministry of Education， Taiyuan University of Technology

School of Physics and Chemistry， Xihua University

Address：No.3888 Dong Nanhu Road, Changchun, Jilin, China Postal code：130033
Tel：0431-86176862 Email：fgxbt@126.com
Technical support is provided by Beijing Founder electronics co., LTD 吉ICP备11002662号-17 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰