Fan LUO, Dong-bin ZHENG, Zhi-qiang YANG, et al. A Novel Curcumin Derivatives Fluorescent Probe for Selective Recognition of Cysteine. [J]. Chinese Journal of Luminescence 42(11):1810-1817(2021)
DOI:
Fan LUO, Dong-bin ZHENG, Zhi-qiang YANG, et al. A Novel Curcumin Derivatives Fluorescent Probe for Selective Recognition of Cysteine. [J]. Chinese Journal of Luminescence 42(11):1810-1817(2021) DOI: 10.37188/CJL.20210211.
A Novel Curcumin Derivatives Fluorescent Probe for Selective Recognition of Cysteine增强出版
cysteine(Cys) is closely related to cell metabolism and redox homeostasis. However
excess amount of Cys is associated with diseases including rheumatoid arthritis
Alzheimer's disease. Thus
it is of great significance to develop a fluorescent probe for selective recognition of cysteine. In this paper
a fluorescence probe based on curcumin-difluoride and modified with 2-chloro-5-nitrobenzoyl was synthesized for the determination of cysteine. The results showed that the probe could selectively recognize Cys. A good linear relationship between the fluorescence intensity of the probe and Cys concentration in the range of 10-70 μmol·L
-1
was obtained
from which the detection limit was deduced to be 2.9 μmol·L
-1
. Meanwhile
the addition of Cys could lead to an obvious colour transition from yellow to colourless
permitting a rapid identification of Cys by the naked eye. Moreover
the probe can simulate the detection of Cys in water samples
and the recoveries of Cys in tap water and river samples ranged from 98%-109%.
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