Research Progress of Fluorescent Probes for Monoamine Oxidases

Xiao-peng WANG; Yong-dong LI; Jian-guo WANG

doi:10.37188/CJL.20210086

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Research Progress of Fluorescent Probes for Monoamine Oxidases

Invited Review | 更新时间：2021-07-22

- Research Progress of Fluorescent Probes for Monoamine Oxidases
  增强出版
- Chinese Journal of Luminescence Vol. 42, Issue 7, Pages: 938-952(2021)
- 作者机构：
  
  1.赣南师范大学化学化工学院　江西省有机药物化学重点实验室，江西　赣州　 341000
  2.内蒙古大学化学化工学院　内蒙古精细有机合成重点实验室，内蒙古　呼和浩特　 010021
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China(21871060);the Natural Science Foundation of Inner Mongolia Autonomous Region of China(2020JQ02;2020MS02004);the Natural Science Foundation of Jiangxi Province(20192BCBL23013);Grassland Talent Program of Inner Mongolia Autonomous Region of China
- DOI：10.37188/CJL.20210086
  CLC： O482.31
- Published：01 July 2021，
  
  Received：12 March 2021，
  
  Revised：02 April 2021，
扫描看全文
Xiao-peng WANG, Yong-dong LI, Jian-guo WANG. Research Progress of Fluorescent Probes for Monoamine Oxidases. [J]. Chinese Journal of Luminescence 42(7):938-952(2021)
DOI：

Xiao-peng WANG, Yong-dong LI, Jian-guo WANG. Research Progress of Fluorescent Probes for Monoamine Oxidases. [J]. Chinese Journal of Luminescence 42(7):938-952(2021) DOI： 10.37188/CJL.20210086.

摘要

单胺氧化酶(Monoamine oxidases

MAOs)是一种膜结合的线粒体酶，通过催化氧化及脱氨反应来维持神经递质和其他生物胺在生物系统中的稳态。MAOs功能障碍与许多神经和精神疾病密切相关，因此，监测MAOs的活性及表达水平，对深入理解其生理功能及相关疾病的临床诊断都具有十分重要的意义。荧光探针具有原位、无创、可实时成像等优势，是准确监测MAOs活性的一种有效方法。本文综述了近年来MAOs荧光探针的研究进展，阐述了这些荧光探针在MAOs相关疾病诊断及治疗中的应用。

Abstract

Monoamine oxidases(MAOs) are a family of membrane-bound mitochondrial enzymes that play important roles in maintaining the homeostasis of neurotransmitters and other bioamines in the biological system through catalytic oxidation and deamination. The dysfunction of MAOs is closely related to many neurological and psychiatric disorders. Thus

monitoring the activity/level of MAOs is of great significance for deeply understanding their physiological functions and for clinical diagnosis of MAOs-related diseases. Fluorescent probes with the ability of

in situ

noninvasive and real-time imaging provide an effective method to accurately detect MAOs activity. In this review

the research progress of fluorescent probes for MAOs in recent years and their applications for the diagnosis and therapy of MAOs-related diseases are reviewed.

关键词

单胺氧化酶荧光探针疾病诊断抑制剂生物成像

Keywords

monoamine oxidasefluorescent probesdisease diagnosisinhibitorbioimaging

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