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Fe3O4纳米粒子的可控制备及其表面改性
Controllable Synthesis and Surface Modification of Fe3O4 Nanoparticles
- 发光学报 2019年40卷第4期 页码：425-431
- 作者机构：
洛阳理工学院 数学与物理教学部,河南 洛阳,471023
- 作者简介：
- 基金信息：国家自然科学基金（51302128）;河南省高等学校青年骨干教师项目（2015GGJS-112）;河南省科技发展计划项目（172102210398，18B140007，172102210404，16A140012）资助
DOI：10.3788/fgxb20194004.0425
中图分类号： O482.31纸质出版日期：2019-4-5，
网络出版日期：2018-9-21，
收稿日期：2018-6-27，
修回日期：2018-8-30，
扫 描 看 全 文
刘利娜, 秦瑞飞, 张永胜等. Fe<sub>3</sub>O<sub>4</sub>纳米粒子的可控制备及其表面改性[J]. 发光学报, 2019,40(4): 425-431
LIU Li-na, QIN Rui-fei, ZHANG Yong-sheng etc. Controllable Synthesis and Surface Modification of Fe<sub>3</sub>O<sub>4</sub> Nanoparticles[J]. Chinese Journal of Luminescence, 2019,40(4): 425-431
刘利娜, 秦瑞飞, 张永胜等. Fe<sub>3</sub>O<sub>4</sub>纳米粒子的可控制备及其表面改性[J]. 发光学报, 2019,40(4): 425-431 DOI： 10.3788/fgxb20194004.0425.
LIU Li-na, QIN Rui-fei, ZHANG Yong-sheng etc. Controllable Synthesis and Surface Modification of Fe<sub>3</sub>O<sub>4</sub> Nanoparticles[J]. Chinese Journal of Luminescence, 2019,40(4): 425-431 DOI： 10.3788/fgxb20194004.0425.
摘要
四氧化三铁（Fe
3
O
4
）因在细胞分离、靶向药物、磁共振成像等生物医学领域具有广阔的应用前景而成为研究热点。本文采用溶剂热法合成了Fe
3
O
4
纳米粒子，并详细研究了反应温度、反应时间和反应前驱体组成对Fe
3
O
4
结构和形貌的影响。实验结果表明，反应时间对球形纳米颗粒的尺寸影响不大，反应时间为12 h时，球的直径达到了最大，继续延长反应时间，球的尺寸保持不变；200℃容易生成大尺寸的Fe
3
O
4
纳米粒子；反应物的组成对Fe
3
O
4
纳米粒子的形貌也有一定的影响，当用水合肼代替乙二胺时，得到的是立方体形状的Fe
3
O
4
。为了增加Fe
3
O
4
纳米粒子的化学稳定性、生物相容性和作为药物载体的可能性，我们用Stber方法在Fe
3
O
4
纳米粒子的表面包覆了一层SiO
2
介孔分子筛，并探索了超声和机械搅拌对核壳结构形貌的影响，还研究了包覆前后样品的磁学性质。
Abstract
Fe
3
O
4
has a wide application prospect in biomedical fields such as cell separation
targeted drugs
magnetic resonance imaging and so on. In this work
Fe
3
O
4
nanoparticles were synthesized by solvothermal method
and the effects of reaction temperature
reaction time and precursor composition on the structure and morphology of Fe
3
O
4
were studied in detail. The reaction time had little effect on the size of the spherical nanoparticles. When the reaction time was 12 h
the diameter of the spheres reached the maximum. When the reaction time was increased
the size of the spheres kept constant. The reaction did not occur when the reaction temperature was 120℃. Face-centered cubic structure Fe
3
O
4
was obtained when the reaction temperature was 160
200
240℃. The diameter of Fe
3
O
4
was maximum when the reaction temperature was 200℃. Cube-shaped Fe
3
O
4
was obtained when ethylenediamine was replaced by hydrazine hydrate. In order to improve the chemical stability
biocompatibility and the possibility using Fe
3
O
4
nanoparticles as drug carriers
a layer of SiO
2
mesoporous molecular sieve was coated on the surface of Fe
3
O
4
by Stber method. The effects of ultrasonic and mechanical stirring on the morphology of core-shell structure were investigated. The magnetic properties of the samples before and after SiO
2
coating were also studied. The samples were all superparamagnetic before and after coating.
关键词
溶剂热法Fe3O4SiO2核壳结构
Keywords
solvothermal methodFe3O4SiO2core-shell
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