近红外到近红外Mn2+掺杂NaYF4:Yb3+/Tm3+纳米粒子的制备及其生物成像

罗阳; 廖正芳; 张伟; 左芳

doi:10.3788/fgxb20183910.1371

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近红外到近红外Mn²⁺掺杂NaYF₄:Yb³⁺/Tm³⁺纳米粒子的制备及其生物成像

材料合成及性能 | 更新时间：2020-08-12

- 近红外到近红外Mn²⁺掺杂NaYF₄:Yb³⁺/Tm³⁺纳米粒子的制备及其生物成像
- Synthesis of NIR-to-NIR Mn²⁺ Doped-NaYF₄: Yb³⁺/Tm³⁺ Nanoparticles and Their Applications in Bioimaging
- 发光学报 2018年39卷第10期页码：1371-1377
- 作者机构：
  
  西南民族大学化学与环境保护工程学院,四川成都,610041
- 作者简介：
- 基金信息：
  
  国家自然科学基金（51273220）();中央高校基础科研项目（2017NZYQN17）资助()
- DOI：10.3788/fgxb20183910.1371
  中图分类号： O482.31
- 纸质出版日期：2018-10-5，
  
  网络出版日期：2018-5-3，
  
  收稿日期：2018-1-4，
  
  修回日期：2018-3-21，
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罗阳, 廖正芳, 张伟等. 近红外到近红外Mn2+掺杂NaYF4:Yb3+/Tm3+纳米粒子的制备及其生物成像[J]. 发光学报, 2018,39(10): 1371-1377

LUO Yang, LIAO Zheng-fang, ZHANG Wei etc. Synthesis of NIR-to-NIR Mn2+ Doped-NaYF4: Yb3+/Tm3+ Nanoparticles and Their Applications in Bioimaging[J]. Chinese Journal of Luminescence, 2018,39(10): 1371-1377
罗阳, 廖正芳, 张伟等. 近红外到近红外Mn2+掺杂NaYF4:Yb3+/Tm3+纳米粒子的制备及其生物成像[J]. 发光学报, 2018,39(10): 1371-1377 DOI： 10.3788/fgxb20183910.1371.

LUO Yang, LIAO Zheng-fang, ZHANG Wei etc. Synthesis of NIR-to-NIR Mn2+ Doped-NaYF4: Yb3+/Tm3+ Nanoparticles and Their Applications in Bioimaging[J]. Chinese Journal of Luminescence, 2018,39(10): 1371-1377 DOI： 10.3788/fgxb20183910.1371.

摘要

在反应温度为200℃、反应时间为8 h的温和条件下，采用水热法合成了近红外到近红外的Mn

掺杂NaYF

:Yb

/Tm

上转换荧光纳米粒子，再以两亲性聚合物C

PMH-mPEG作为亲水性配体修饰到上转换荧光纳米粒子表面，得到具有水溶性的上转换荧光纳米粒子。然后在980 nm近红外光源激发下，测量了上转换荧光纳米粒子的荧光发射光谱，在（80010） nm附近，观察到了较强的单近红外光发射（

）。对样品进行细胞毒性实验，结果表明制得的水溶性Mn

掺杂NaYF

:Yb

/Tm

纳米粒子具有良好的生物相容性。并进一步在小鼠体内进行了近红外成像，表明其在生物成像领域将会具有一定的应用前景。

Abstract

doped-NaYF

:Yb

/Tm

upconversion fluorescence nanoparticles(NPs) were synthesized by one-step hydrothermal method under 200℃ for 8 h

and then the hydrophobic nanoparticles were transferred into water through coating amphiphilic polymer C

PMH-mPEG. Upconversion fluorescence emission spectrum of Mn

doped-NaYF

:Yb

/Tm

NPs was measured under excitation by a near-infrared(NIR) light at 980 nm. The results of cytotoxicity test show that the water-soluble Mn

doped-NaYF

:Yb

/Tm

NPs have good biocompatibility. Moreover

the prepared Mn

doped-NaYF

:Yb

/Tm

NPs are used for in mice NIR imaging

which shows that it will have a certain application prospect in bioimaging.

关键词

水热法Yb3+/Tm3+上转换纳米粒子生物成像

Keywords

hydrothermalYb3+/Tm3+upconversionnanoparticlesbioimaging

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