金纳米星/双锥的可控制备、光热转换及体外光热治疗

吴頔; 樊淼; 张露云; 邢晶晶; 吕树芳; 曾乐勇

doi:10.3788/fgxb20183903.0280

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金纳米星/双锥的可控制备、光热转换及体外光热治疗

材料合成及性能 | 更新时间：2020-08-12

- 金纳米星/双锥的可控制备、光热转换及体外光热治疗
- Controllable Synthesis, Photothermal Conversion and in vitro Photothermal Therapy of Gold Nanostars/Nanobipyramids
- 发光学报 2018年39卷第3期页码：280-286
- 作者机构：
  
  河北大学化学与环境科学学院,河北保定,071002
- 作者简介：
- 基金信息：
  
  国家自然科学基金（51772074，U1732127）();河北省科技厅重点基础研究项目（17961302D）();河北省教育厅青年拔尖人才项目（BJ2017002）(
- DOI：10.3788/fgxb20183903.0280
  中图分类号： O482.31
- 纸质出版日期：2018-3-5，
  
  收稿日期：2017-9-14，
  
  修回日期：2017-12-13，
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吴頔, 樊淼, 张露云等. 金纳米星/双锥的可控制备、光热转换及体外光热治疗[J]. 发光学报, 2018,39(3): 280-286

WU Di, FAN Miao, ZHANG Lu-yun etc. Controllable Synthesis, Photothermal Conversion and <em>in vitro</em> Photothermal Therapy of Gold Nanostars/Nanobipyramids[J]. Chinese Journal of Luminescence, 2018,39(3): 280-286
吴頔, 樊淼, 张露云等. 金纳米星/双锥的可控制备、光热转换及体外光热治疗[J]. 发光学报, 2018,39(3): 280-286 DOI： 10.3788/fgxb20183903.0280.

WU Di, FAN Miao, ZHANG Lu-yun etc. Controllable Synthesis, Photothermal Conversion and <em>in vitro</em> Photothermal Therapy of Gold Nanostars/Nanobipyramids[J]. Chinese Journal of Luminescence, 2018,39(3): 280-286 DOI： 10.3788/fgxb20183903.0280.

摘要

采用种子生长法，分别制备了金纳米星和金纳米双锥，利用透射电子显微镜、紫外-可见（UV-Vis）分光光度计等对样品进行了表征，并评价了金纳米星和金纳米双锥的光热转换性能、生物相容性以及体外光热治疗性能。结果表明，金纳米星和金纳米双锥的UV-Vis吸收峰位于808 nm和815 nm左右。在808 nm激光辐照下，光热转换效率分别为48.43%和53.68%。细胞实验表明，金纳米星和金纳米双锥具有良好的生物相容性。808 nm激光辐照5 min后，MCF-7细胞存活率分别降至22.54%和13.73%；且在同等条件下，金纳米双锥具有更加优异的光热治疗性能，是一种安全、高性能的肿瘤光热治疗用纳米探针材料。

Abstract

Using seed-growth method

gold nanostars and gold nanobipyramids were synthesized

respectively

and they were characterized by transmission electron microscope and ultraviolet-visible (UV-Vis) spectrophotometer. Moreover

the photothermal conversion

biocompatibility and

in vitro

photothermal therapy (PTT) of gold nanostars and gold nanobipyramids were evaluated. The results show that the UV-Vis absorption peaks of gold nanostars and gold nanobipyramids are located at about 808 nm and 815 nm

and the photothermal conversion efficiency is calculated to be 48.43% and 53.68%. The cell experiments indicate that the gold nanostars and gold nanobipyramids have good biocompatibility

and the viabilities of MCF-7 cells incubate with gold nanostars and gold nanobipyramids are decreased to be about 22.54% and 13.73%

after they are irradiated by 808 nm laser for 5 min

respectively. Furthermore

compared with the gold nanostars

the gold nanobipyramids have more excellent PTT performance

which could be good candidate as safe and high-efficient nanoprobe material for PTT in tumors.

关键词

金纳米星金纳米双锥光热治疗

Keywords

gold nanostarsgold nanobipyramidsphotothermal therapy

references

CHENG L, WANG C, FENG L Z, et al.. Functional nanomaterials for phototherapies of cancer[J]. Chem. Rev., 2014, 114:10869-10939.

SHANMUGAM V, SELVAKUMAR S, YEH C S. Near-infrared light-responsive nanomaterials in cancer therapeutics[J]. Chem. Soc. Rev., 2014, 43:6254-6287.

ZOU L L, WANG H, HE B, et al.. Current approaches of photothermal therapy in treatmenting cancer matastasis with nanotherapeeutics[J]. Theranostics, 2016, 6:762-772.

WANG C, BLACK K C L, LUEHMANN H, et al.. Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment[J]. ACS Nano, 2013, 7:2068-2077.

ZHOU M, LI J J, LIANG S, et al.. CuS nanodots with ultrahigh efficient renal clearance for positron emission tomography imaging and image-guided photothermal therapy[J]. ACS Nano, 2015, 9:7085-7096.

LI C, KWON W, BEACK S, et al.. Biodegradable nitrogen-doped carbon nanodots for non-invasive photoacoustic imaging and photothermal therapy[J]. Theranostics, 2016, 6:2196-2208.

李奕杉, 钟年丙, 廖强, 等. 基于六硼化镧与壳聚糖的光热转换生物材料[J]. 发光学报, 2017, 38(8):1021-1027. LI Y S, ZHONG B N, LIAO Q, et al.. Photo-thermal biomaterials based on lanthanum hexaboride (LaB6) and chitosan[J]. Chin. J. Lumin., 2017, 38(8):1021-1027. (in Chinese)

李欣远, 纪穆为, 王虹智, 等. 近红外光热转换纳米晶研究进展[J]. 中国光学, 2017, 10(5):541-554. LI X Y, JI M W, WANG H Z, et al.. Research progress of near-infrared photothermal conversion nanocrystals[J]. Chin. Opt., 2017, 10(5):541-554. (in Chinese)

ZHOU J, LU Z G, ZHU X J, et al.. NIR photothermal therapy using polyaniline nanoparticles[J]. Biomaterials, 2013, 34:9584-9592.

ZOU Q L, ABBAS M, ZHAO L Y, et al.. Biological photothermal nanodots based on self-assembly of peptide-porphyrin conjugates for antitumor therapy[J]. J. Am. Chem. Soc., 2017, 139:1921-1927.

YANG X, YANG M X, PANG B, et al.. Gold nanomaterials at work in biomedicine[J]. Chem. Rev., 2015, 115:10410-10488.

DREADEN E C, ALKILANY A M, HUANG X H, et al.. The golden age:gold nanoparticles for biomedicine[J]. Chem. Soc. Rev., 2012, 41:2740-2779.

WANG S J, HUANG P, NIE L M, et al.. Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars[J]. Adv. Mater., 2013, 25:3055-3061.

FENG J, CHEN L M, XIA Y Z, et al.. Bioconjugation of gold nanobipyramids for simultaneous SERS detection and targeted photothermal therapy in breast cancer[J]. ACS Biomater. Sci. Eng., 2017, 3:608-618.

LIU Y, AI K, LIU J, et al.. Dopamine-melanin colloidal nanospheres:an efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy[J]. Adv. Mater., 2013, 25:1353-1359.

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