微波水热法制备Gd3+掺杂的碳量子点型高性能磁共振-荧光双模态分子影像探针

袁雪霞; 王超; 王玉平; 胡清; 任先艳

doi:10.3788/fgxb20153612.1383

您当前的位置：

首页 >

文章列表页 >

微波水热法制备Gd³⁺掺杂的碳量子点型高性能磁共振-荧光双模态分子影像探针

材料合成及性能 | 更新时间：2020-08-12

- 微波水热法制备Gd³⁺掺杂的碳量子点型高性能磁共振-荧光双模态分子影像探针
- Synthesis of Magnetic Resonance/Fluorescence Bimodal Molecular Imaging Probe Based on Gadolinium-doped Carbon Quantum Dots by Microwave-hydrothermal Method
- 发光学报 2015年36卷第12期页码：1383-1389
- 作者机构：
  
  1. 西南科技大学材料科学与工程学院, 四川绵阳 621010
  2. 北川天诺光电材料有限公司, 四川绵阳 622750
- 作者简介：
- 基金信息：
  
  国家自然科学基金(81171318) 资助项目()
- DOI：10.3788/fgxb20153612.1383
  中图分类号： O482.31
- 纸质出版日期：2015-12-10，
  
  收稿日期：2015-8-26，
  
  修回日期：2015-10-21，
扫描看全文
袁雪霞, 王超, 王玉平等. 微波水热法制备Gd3+掺杂的碳量子点型高性能磁共振-荧光双模态分子影像探针[J]. 发光学报, 2015,36(12): 1383-1389

YUAN Xue-xia, WANG Chao, WANG Yu-ping etc. Synthesis of Magnetic Resonance/Fluorescence Bimodal Molecular Imaging Probe Based on Gadolinium-doped Carbon Quantum Dots by Microwave-hydrothermal Method[J]. Chinese Journal of Luminescence, 2015,36(12): 1383-1389
袁雪霞, 王超, 王玉平等. 微波水热法制备Gd3+掺杂的碳量子点型高性能磁共振-荧光双模态分子影像探针[J]. 发光学报, 2015,36(12): 1383-1389 DOI： 10.3788/fgxb20153612.1383.

YUAN Xue-xia, WANG Chao, WANG Yu-ping etc. Synthesis of Magnetic Resonance/Fluorescence Bimodal Molecular Imaging Probe Based on Gadolinium-doped Carbon Quantum Dots by Microwave-hydrothermal Method[J]. Chinese Journal of Luminescence, 2015,36(12): 1383-1389 DOI： 10.3788/fgxb20153612.1383.

摘要

以同时提供钆源和碳源的钆喷酸单葡甲胺为前驱体

利用微波作为加热手段实现分子水平上的搅拌

达到低温、短时间内制得均匀的小粒度Gd

掺杂碳量子点(Gd

/CQDs-MH)的目的。当前驱体在250 ℃下微波水热反应45 min时

获得的Gd

/CQDs-MH表现出较高的量子产率和极强的磁共振性能

避免了传统加热方式对碳量子点的发光能力和弛豫性能极难同时提高的矛盾。该条件下合成出尺寸约1.0 nm的碳量子点

其荧光量子产率为11.0%

的掺杂质量分数达16.9%

纵向弛豫性能高达4 545.3 mmol

-1

([Gd

]=0.01 mmolL

-1

)。并且

该碳量子点对HeLa细胞无明显毒性

有望用作高弛豫性能和高发光性能的磁共振-荧光双模态探针。

Abstract

Using gadopentetic acid monomeglumine (GdPM) as precursor to provide simultaneously the carbon source and gadolinium (3+) source

gadolinium-doped carbon quantum dots (Gd

/CQDs-MH) with uniformly small size were obtained at a mild condition by microwave hydrothermal method which can realize a molecular level mixing. When GdPM was pyrolyzed under 250 ℃ for 45 min

/CQDs-MH with high quantum yield (QY) and longitudinal relaxation rate (

) were obtained. The contradiction between quantum yield and the relaxation properties has been well balanced

which is very difficult to avoid using traditional heating method. The prepared Gd

/CQDs-MH with an average diameter of about 1.0 nm show little cell toxicity and exhibit a high photoluminescence quantum yield of 11.0%

as well as a high

value of 4 545.3 mmol

-1

([Gd

]=0.01 mmolL

-1

) with the doping mass fraction of gadolinium (3+) of 16.9%. Therefore

the Gd

/CQDs-MH show big possibility for application in magnetic resonance/fluorescence bimodal molecular imaging.

关键词

碳量子点钆离子磁共振荧光分子影像探针

Keywords

carbon quantum dotsgadolinium ionsmagnetic resonancefluorescencemolecular imaging probe

references

Yang Z C, Wang M, Yong A M, et al. Intrinsically fluorescent carbon dots with tunable emission derived from hydrothermal treatment of glucose in the presence of monopotassium phosphate [J]. Chem. Commun., 2011, 47(42):11615-11617.

Yang Y, Cui J, Zheng M, et al. One-step synthesis of amino-functionalized fluorescent carbon nanoparticles by hydrothermal carbonization of chitosan [J]. Chem. Commun., 2012, 48(3):380-382.

Wu Z L, Zhang P, Gao M X, et al. One-pothydrothermal synthesis of highly luminescent nitrogen-doped amphoteric carbon dots for bioimaging from bombyx mori silk-natural proteins [J]. J. Mater. Chem. B, 2013, 1(22):2868-2873.

Wang X H, Qu K G, Xu B L, et al. Microwave assisted one-step green synthesis of cell-permeable multicolor photoluminescent carbon dots without surface passivation reagents [J]. J. Mater. Chem., 2011, 21(8):2445-2450.

Wang Q L, Zheng H Z, Long Y J, et al. Microwave-hydrothermal synthesis of fluorescent carbon dots from graphite oxide [J]. Carbon, 2011, 49(9):3134-3140.

Ren, X Y, Liu L H, Li Y, et al. Facile preparation of gadolinium(iii) chelates functionalized carbon quantum dot-based contrast agent for magnetic resonance/fluorescence multimodal imaging [J]. J. Mater. Chem. B, 2014, 2(34):5541-5549.

Kim J S, Rieter W J, Taylor K M, et al. Self-assembled hybrid nanoparticles for cancer-specific multimodal imaging [J]. J. Am. Chem. Soc., 2007, 129(29):8962-8963.

Nie H, Li M J, Li Q S, et al. Carbon dots with continuously tunable full-color emission and their application in ratiometric pH sensing [J]. Chem. Mater., 2014, 26(10):3104-3112.

Dong Y G, Yang J L, Ding Y L, et al. Size-controllable synthesis of highly fluorescent carbon quantum dots in a reverse microemusion [J]. Chin. J. Lumin.(发光学报), 2015, 36(2):157-162 (in Chinese).

Shi X, Xu J P, Li L L, et al. Photoelectro chemical properties of TiO2 nanorod arrays loaded with carbon quantum dots [J]. Chin. J. Lumin.(发光学报), 2015, 36(8):898-905 (in Chinese).

Siriwardena Mahanama B N, Allen M J. Strategies for optimizing water-exchange rates of lanthanide-based contrast agents for magnetic resonance imaging [J]. Molecules, 2013, 18(8):9352-9381.

Sitharaman B, Kissell K R, Hartman K B, et al. Superparamagnetic gadonanotubes are high-performance MRI contrast agents [J]. Chem. Commun., 2005, 41(31):3915-3917.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

兼具磁共振响应的碳量子点光致发光材料的构筑和性能

交联剂改善羧基化石墨烯量子点荧光性能

煤基碳量子点制备及对环境水中Cr（Ⅵ）的测定

硫醇⁃烯交联增强碳量子点发光效率机理研究

淡竹叶碳量子点的微波法制备及在细胞成像中的应用探究