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1. 西南科技大学 材料科学与工程学院, 四川 绵阳 621010
2. 北川天诺光电材料有限公司, 四川 绵阳 622750
纸质出版日期:2015-12-10,
收稿日期:2015-8-26,
修回日期:2015-10-21,
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袁雪霞, 王超, 王玉平等. 微波水热法制备Gd<sup>3+</sup>掺杂的碳量子点型高性能磁共振-荧光双模态分子影像探针[J]. 发光学报, 2015,36(12): 1383-1389
YUAN Xue-xia, WANG Chao, WANG Yu-ping etc. Synthesis of Magnetic Resonance/Fluorescence Bimodal Molecular Imaging Probe Based on Gadolinium-doped Carbon Quantum Dots by Microwave-hydrothermal Method[J]. Chinese Journal of Luminescence, 2015,36(12): 1383-1389
袁雪霞, 王超, 王玉平等. 微波水热法制备Gd<sup>3+</sup>掺杂的碳量子点型高性能磁共振-荧光双模态分子影像探针[J]. 发光学报, 2015,36(12): 1383-1389 DOI: 10.3788/fgxb20153612.1383.
YUAN Xue-xia, WANG Chao, WANG Yu-ping etc. Synthesis of Magnetic Resonance/Fluorescence Bimodal Molecular Imaging Probe Based on Gadolinium-doped Carbon Quantum Dots by Microwave-hydrothermal Method[J]. Chinese Journal of Luminescence, 2015,36(12): 1383-1389 DOI: 10.3788/fgxb20153612.1383.
以同时提供钆源和碳源的钆喷酸单葡甲胺为前驱体
利用微波作为加热手段实现分子水平上的搅拌
达到低温、短时间内制得均匀的小粒度Gd
3+
掺杂碳量子点(Gd
3+
/CQDs-MH)的目的。当前驱体在250 ℃下微波水热反应45 min时
获得的Gd
3+
/CQDs-MH表现出较高的量子产率和极强的磁共振性能
避免了传统加热方式对碳量子点的发光能力和弛豫性能极难同时提高的矛盾。该条件下合成出尺寸约1.0 nm的碳量子点
其荧光量子产率为11.0%
Gd
3+
的掺杂质量分数达16.9%
纵向弛豫性能高达4 545.3 mmol
-1
Ls
-1
([Gd
3+
]=0.01 mmolL
-1
)。并且
该碳量子点对HeLa细胞无明显毒性
有望用作高弛豫性能和高发光性能的磁共振-荧光双模态探针。
Using gadopentetic acid monomeglumine (GdPM) as precursor to provide simultaneously the carbon source and gadolinium (3+) source
gadolinium-doped carbon quantum dots (Gd
3+
/CQDs-MH) with uniformly small size were obtained at a mild condition by microwave hydrothermal method which can realize a molecular level mixing. When GdPM was pyrolyzed under 250 ℃ for 45 min
Gd
3+
/CQDs-MH with high quantum yield (QY) and longitudinal relaxation rate (
r
1
) were obtained. The contradiction between quantum yield and the relaxation properties has been well balanced
which is very difficult to avoid using traditional heating method. The prepared Gd
3+
/CQDs-MH with an average diameter of about 1.0 nm show little cell toxicity and exhibit a high photoluminescence quantum yield of 11.0%
as well as a high
r
1
value of 4 545.3 mmol
-1
Ls
-1
([Gd
3+
]=0.01 mmolL
-1
) with the doping mass fraction of gadolinium (3+) of 16.9%. Therefore
the Gd
3+
/CQDs-MH show big possibility for application in magnetic resonance/fluorescence bimodal molecular imaging.
碳量子点钆离子磁共振荧光分子影像探针
carbon quantum dotsgadolinium ionsmagnetic resonancefluorescencemolecular imaging probe
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