四苯乙烯类聚集诱导发光探针在生物分子检测领域的应用

杨学琴; 来守军; 丁媛媛; 马丽丽; 王晶凤; 关晓琳

doi:10.37188/CJL.20220080

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四苯乙烯类聚集诱导发光探针在生物分子检测领域的应用

发光学应用及交叉前沿 | 更新时间：2022-10-19

- 四苯乙烯类聚集诱导发光探针在生物分子检测领域的应用
  增强出版
- Application of Tetraphenylene Aggregation-induced Emission Probes in Field of Biomolecular Detection
- 发光学报 2022年43卷第6期页码：961-985
- 作者机构：
  
  1.西北师范大学化学化工学院，甘肃兰州　730070
  2.兰州文理学院化工学院，甘肃兰州　730000
- 作者简介：
  
  [ "杨学琴（1996-），女，甘肃会宁人，硕士研究生，2019年于兰州文理学院获得学士学位，主要从事AIE荧光探针及其在生物成像方面应用的研究。Email: 2410121332@qq.com" ]
  [ "关晓琳（1979-），女，甘肃兰州人，博士，副教授，硕士生导师，2007 年于兰州大学获得博士学位，主要从事生物荧光成像探针和药物释放领域的各类量子点材料及功能AIE 聚合物的研究。Email: guanxiaolin@nwnu.edu.cn" ]
- 基金信息：
  
  国家自然科学基金(21761032;21965032;51302222;1363021);甘肃省自然科学研究基金(20JR5RA525;20JR10RA143);兰州文理学院博士专项计划基金(2020BSZX08)
- DOI：10.37188/CJL.20220080
  中图分类号：
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杨学琴, 来守军, 丁媛媛, 等. 四苯乙烯类聚集诱导发光探针在生物分子检测领域的应用[J]. 发光学报, 2022,43(6):961-985.

YANG Xue-qin, LAI Shou-jun, DING Yuan-yuan, et al. Application of Tetraphenylene Aggregation-induced Emission Probes in Field of Biomolecular Detection[J]. Chinese Journal of Luminescence, 2022,43(6):961-985.
杨学琴, 来守军, 丁媛媛, 等. 四苯乙烯类聚集诱导发光探针在生物分子检测领域的应用[J]. 发光学报, 2022,43(6):961-985. DOI： 10.37188/CJL.20220080.

YANG Xue-qin, LAI Shou-jun, DING Yuan-yuan, et al. Application of Tetraphenylene Aggregation-induced Emission Probes in Field of Biomolecular Detection[J]. Chinese Journal of Luminescence, 2022,43(6):961-985. DOI： 10.37188/CJL.20220080.

摘要

生物体内存在各类生物离子和分子，其含量变化可以反映生物体的健康情况。因此，开发用于监测生物系统中离子或分子含量的方法是非常重要的。近年来，具有聚集诱导发光（Aggregation⁃induced emission，AIE）性质的荧光材料由于其独特的光电性能及生物活性，在光电材料、化学传感、生物成像等领域展现出广泛的应用前景。目前，在具有较高荧光量子产率的聚集诱导发光分子（AIEgens）中，四苯乙烯（TPE）成为最具有代表性和常用的分子之一，具有合成简便、易功能化以及优异的AIE效应等优点。本文综述了近年来基于TPE的荧光材料在生物金属离子、生物小分子和生物大分子检测方面的研究进展，分析了基于TPE的荧光探针所面临的挑战，并对其应用前景进行了展望，以期为制备合成简单、生物相容性好、检出限低的AIE荧光探针提供参考。

Abstract

There are various types of biometal ions and biomolecules in the organism and their content changes can reflect the health of living body. Therefore， it is very important to develop a detection method for monitoring the content of biometal ions or biomolecules in biological systems. In recent years， fluorescent materials with enhanced properties of aggregation-induced emission（AIE） have shown wide application prospects in the fields of optoelectronic materials， chemical sensing， and bio-imaging due to their unique optoelectronic properties and biological activities. At present， tetraphenylethylene（TPE） has become one of the most representative and commonly used molecules among aggregation-induced luminescent molecules（AIEgens） with high fluorescence quantum yield， which has the advantages of simple synthesis， easy to functionalize， and excellent AIE effect. This paper reviews the research progress of tetraphenylethylene-based fluorescent materials in the detection of biometal ions， small biomolecules and biomacromolecules in recent years. The challenges faced of fluorescent probes are analyzed and the development prospects are expected. It is expected to provide a reference for preparing and synthesizing fluorescent probes with good biocompatibility and low detection limit.

关键词

聚集诱导发光四苯乙烯生物金属离子生物小分子生物大分子

Keywords

aggregation-induced emissiontetraphenylethylenebiometal ionssmall biomoleculebiomacromolecule

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