基于三苯胺的增强型Fe<sup>3+</sup>荧光探针及性能

尚主业; 舒丽; 王月; 孟庆涛; 贾宏敏; 张志强

doi:10.37188/CJL.20210386

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基于三苯胺的增强型Fe³⁺荧光探针及性能

发光学应用及交叉前沿 | 更新时间：2022-04-07

- 基于三苯胺的增强型Fe³⁺荧光探针及性能
  增强出版
- Synthesis and Performances of Triphenylamine Based Turn-on Fluorescent Probe for Fe³⁺ by An Enhancement Pattern
- 发光学报 2022年43卷第3期页码：453-461
- 作者机构：
  
  辽宁科技大学　化学工程学院，辽宁　鞍山　114051
- 作者简介：
  
  尚主业(1996-)，男，辽宁鞍山人，博士研究生，2019 年于辽宁科技大学获得学士学位，主要从事分子识别与生物成像方面的应用基础研究。E-mail: shangzhuye@163.com
  孟庆涛(1981-)，男，山东曲阜人，博士，教授，博士生导师，2011年于大连理工大学获得博士学位，主要从事生物及医用新材料(包括生物传感与生物成像材料、医用诊断与治疗材料和新型有机荧光染料等)方面的应用基础研究。E-mail: qtmeng@ustl.edu.cn
  张志强(1964-)，男，吉林通榆人，博士，教授，博士生导师，2009年于大连理工大学获得博士学位，主要从事精细化学品的研制及应用、功能性有机化合物的设计、合成及应用、荧光分子探针的设计、合成及应用、过渡金属催化反应等的研究。E-mail: zzq@ustl.edu.cn
- 基金信息：
  
  辽宁省“百千万人才计划”;辽宁省教育厅重点项目(LJKZ0277);辽宁省教育厅科技计划(2019LNQN03;2019LNJC18)
- DOI：10.37188/CJL.20210386
  中图分类号： O482.31
- 收稿：2021-12-08，
  
  修回：2021-12-23，
  
  纸质出版：2022-03
- 稿件说明：
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尚主业, 舒丽, 王月, 等. 基于三苯胺的增强型Fe³⁺荧光探针及性能[J]. 发光学报, 2022,43(3):453-461. DOI: 10.37188/CJL.20210386.

Zhu-ye SHANG, Li SHU, Yue WANG, et al. Synthesis and Performances of Triphenylamine Based Turn-on Fluorescent Probe for Fe³⁺ by An Enhancement Pattern[J]. Chinese Journal of Luminescence, 2022, 43(3): 453-461. DOI: 10.37188/CJL.20210386.
尚主业, 舒丽, 王月, 等. 基于三苯胺的增强型Fe³⁺荧光探针及性能[J]. 发光学报, 2022,43(3):453-461. DOI: 10.37188/CJL.20210386. DOI：

Zhu-ye SHANG, Li SHU, Yue WANG, et al. Synthesis and Performances of Triphenylamine Based Turn-on Fluorescent Probe for Fe³⁺ by An Enhancement Pattern[J]. Chinese Journal of Luminescence, 2022, 43(3): 453-461. DOI: 10.37188/CJL.20210386. DOI：

摘要

在人的许多生理过程中扮演着重要的角色，例如氧气运输、DNA合成、髓磷脂合成、线粒体呼吸、神经递质合成和代谢等。然而，过量的Fe

会诱导细胞产生·OH从而引起细胞损伤，并且还会诱导β-地中海贫血、帕金森病、癫痫和阿尔茨海默病等疾病的发生。因此，对Fe

的检测和监测具有非常重要的意义。本文设计并合成了一种以三苯胺为母体的增强型Fe

荧光探针

，并将其应用于实际水样中Fe

的识别。结果表明，探针

对Fe

的识别具有较高的灵敏度，其检测限低至0.165 μmol·L

-1

。同时，Fe

的加入会导致探针溶液的荧光颜色由蓝绿色变为黄色，能够达到“裸眼”识别的效果。通过高分辨率质谱证明了探针与Fe

为1∶1配位。利用密度泛函理论计算了识别Fe

前后轨道能级和电能的变化并解释了其荧光光谱现象。

Abstract

plays an important role in many physiological processes

such as oxygen transport

DNA synthesis

myelin synthesis

mitochondrial respiration

neurotransmitter synthesis and metabolism. However

excessive Fe

can induce cells to produce a large amount of ·OH and result in cell damage

which can also cause a variety of diseases

such as β-thalassemia

Parkinson‘s disease

epilepsy and Alzheimer‘s disease. Therefore

it is of great significance to detect and monitor Fe

. In this paper

a fluorescence enhanced Fe

probe

based on triphenylamine is designed and synthesized

and it is also applied to the recognition of Fe

in real water samples. The results show that the probe

has a high sensitivity for Fe

recognition

and the detection limit is as low as 0.165 μmol·L

-1

. At the same time

upon the addition of Fe

an obvious change in the colour of the

solution from turquoise to yellow is observed

allowing for colorimetric detection of Fe

by the "naked eye" . The 1∶1 coordination mode between

and Fe

is further proved by high resolution mass spectrometry. Density functional theory(DFT) is used to calculate the changes of energy level and energy of the orbital before and after coordination with Fe

and explain the phenomenon of its fluorescence spectrum.

关键词

Keywords

references

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Synthesis and Performances of Triphenylamine Based Turn-on Fluorescent Probe for Fe3+ by An Enhancement Pattern

DOI：10.37188/CJL.20210386

摘要

Abstract

关键词

Keywords

references

基于三苯胺的增强型Fe³⁺荧光探针及性能

Synthesis and Performances of Triphenylamine Based Turn-on Fluorescent Probe for Fe³⁺ by An Enhancement Pattern