浏览全部资源
扫码关注微信
基于香豆酰肼的高选择性的铜离子荧光探针
Highly Sensitive Fluorescent Coumarin-based Probes for Selective Detection of Copper Ion
- 发光学报 2010年31卷第3期 页码：433-438
- 作者机构：
大连理工大学化学系 精细化工国家重点实验室,辽宁 大连,116024
- 作者简介：
- 基金信息：
DOI：
中图分类号： O482.31纸质出版日期：2010-6-30，
网络出版日期：2010-6-30，
收稿日期：2010-1-10，
修回日期：1900-1-2，
扫 描 看 全 文
赵秀文, 张亚男, 何广杰, 等. 基于香豆酰肼的高选择性的铜离子荧光探针[J]. 发光学报, 2010,31(3):433-438.
ZHAO Xiu-wen, ZHANG Ya-nan, HE Guang-jie, et al. Highly Sensitive Fluorescent Coumarin-based Probes for Selective Detection of Copper Ion[J]. Chinese Journal of Luminescence, 2010,31(3):433-438.
摘要
设计合成了含有香豆酰肼官能团的铜离子荧光探针
N
N-二乙基氨基香豆素-3-酰肼吡啶醛(XB)
该探针在水溶液中 ∶
V
(H
2
O)=1 ∶ 1]对铜离子识别和检测具有较高的灵敏度和选择性。碱金属和碱土金属离子K
+
、Na
+
、Mg
2+
、Ca
2+
以及过渡金属离子Cr
3+
、Mn
2+
、Fe
3+
、Co
2+
、Ni
2+
、Zn
2+
、Cd
2+
、Hg
2+
和Ag
+
等对Cu
2+
离子的识别无显著影响。光谱滴定和ESI-MS谱表明Cu
2+
离子与XB以1 ∶ 2的化学计量比形成配合物。
Abstract
By combining 7-diethylamino-2-oxo-2H-chromene-3-carbohydrazide with 2-pyridylaldehyde into one molecule
fluorescent probe XB was synthesized for detection of Cu
2+
in aqueous solution
V
(CH
3
CN) ∶
V
(H
2
O)=1 ∶ 1). The probe is highly selective for Cu
2+
over biologically relevant alkali metals
alkaline earth metals and the first row transition metals such as Cr
3+
Mn
2+
Fe
3+
Co
2+
Ni
2+
Zn
2+
Cd
2+
and Hg
2+
. Spectrophotometric titration and ESI-MS spectra indicate the formation of a 1 ∶ 2 complex of Cu
2+
with XB.
关键词
荧光探针Cu2+香豆素化学传感器
Keywords
fluorescent probeCu2＋coumarinchemosensor
references
. Barceloux D G J, Barceloux D. Copper [J]. Clin. Toxicol., 1999, 37 (2):217-230.
. Tapiero H, Townsend D M, Tew K D. Trace elements in human physiology and pathology [J]. Biomed. Pharmacother, 2003, 57 (9):386-398.
. Jung H S, Kwon P S, Lee J W, et al. Coumarin-derived Cu2+-selective fluorescence sensor: Synthesis, mechanisms, and applications in living cells [J]. J. Am. Chem. Soc., 2009, 131 (5):2008-2012.
. Puig S, Thiele D J. Molecular mechanisms of copper uptake and distribution [J]. Curr. Opin. Chem. Biol., 2002, 6 (2):171-180.
. Harrison M D, Dameron C T. Molecular mechanisms of the Menkes disease protein [J]. J. Biochem. Mol. Toxicol.,1999, 13 (2):93-106.
. Strausak D, Mercer J F B, Dieter H H, et al. Copper in disorders with neurological symptoms: Alzheimers, Menkes, and Wilson diseases [J]. Brain Res. Bull., 2001, 55 (2):175-185.
. Mercer J F B. The molecular basis of copper-transport diseases [J]. Trends Mol. Med., 2001, 7 (2):64-69.
. Waggoner D J, Bartnikas T B, Gitlin J D. The role of copper in neurodegenerative diseas [J]. Neurobiol. Dis., 1999, 6 (4):221-230.
. Rae T D, Schmidt P J, Pufahl R A, et al. Undetectable intracellular free copper: The requirement of a copper chaperone for superoxide dismutase [J]. Science, 1999, 284 (5415):805-808.
. Wong B A, Friedle Sand Lippard S J. Solution and fluorescence properties of symmetric dipicolylamine-containing dichloro- fluorescein-based Zn2+ sensors [J]. J. Am. Chem. Soc., 2009, 131 (20):7142-7152.
. Huang W, Song C, He C, et al. Recognition preference of rhodamine-thiospirolactams for mercury(Ⅱ) in aqueous solution [J]. Inorg. Chem., 2009, 48 (12):5061-5072.
. Jana A, Kim J S, Jung H S, et al. A cryptand based chemodosimetric probe for naked-eye detection of mercury(II) ion in aqueous medium and its application in live cell imaging [J]. Chem. Comm., 2009, (29):4417-4419.
. Wu H, Zhou Peng, Wang J, et al. Dansyl-based fluorescent chemosensors for selective responses of Cr(Ⅲ) [J]. New J. Chem., 2009, 33 (3):653-658.
. Wu H, He C, Wang J, et al. Hydrolysis-activated fluorophore system as a molecular sensor for selective detection of Zn2+ [J]. Chin. J. Lumin.(发光学报), 2009, 30 (3):275-283 (in Chinese).
. Dodani S C, He Q, Chang C J. A turn-on fluorescent sensor for detecting nickel in living cells [J]. J. Am. Chem. Soc., 2009, 131 (50):18020-18021.
. Li G K, Xu Z X, Chen C F. A highly efficient and selective turn-on fluorescent sensor for Cu2+ ion based on calix
. arene bearing four iminoquinoline subunits on the upper rim [J]. Chem. Comm., 2008, (28):1774-1776.
. Swamy K M K, Ko S K, Kwon S K, et al. Boronic acid-linked fluorescent and colorimetric probes for copper ions [J].Chem. Comm., 2008, (28):5915-5917.
. Yu M, Shi M, Chen Z, et al. Highly sensitive and fast responsive fluorescence turn-on chemodosimeter for Cu2+ and its application in live cell Imaging [J]. Chem. Eur. J., 2008, 14 (23):6892-6900.
. Wen Z C, Yang R, He H, et al. A highly selective charge transfer fluoroionophore for Cu2+ [J]. Chem. Comm., 2006, (2):106-108.
. Zhou Y, Wang F, Kim Y, et al. Cu2+-selective ratiometric and "Off-On" sensor based on the rhodamine derivative bea-ring pyrene group [J]. Org. Lett., 2009, 11 (19):4442-4445.
. SMART SA INT, Area detector control and integration software, siemens analytical X-ray systems . Madison: Inc. Madison. WI, 1996.
. Sheldrick G M, SHELXTL V5.1, Software ReferenceManual, Bruker, AXS . Madison: Inc. Madison WI, 1997.
. Nolan E M, Burdette S C, Harvey J H, et al. Synthesis and characterization of zinc sensors based on a monosubstituted fluorescein platform [J]. Inorg. Chem., 2004, 43 (8):2624-2635.
. Liu J W, Lu Y. A DNAzyme catalytic beacon sensor for paramagnetic Cu2+ ions in aqueous solution with high sensitivity and selectivity [J]. J. Am. Chem. Soc., 2007, 129 (32):9838-9839.
. Jiang P, Guo Z. Fluorescent detection of zinc in biological systems: recent development on the design of chemosensors and biosensors [J]. Coord. Chem. Rev., 2004, 248 (1-2):205-229.
. Krmer R. Fluorescent chemosensors for Cu2+ ions: Fast, selective, and highly sensitive [J]. Angew. Chem. Int. Ed., 1998, 37 (6):772-773.
0
浏览量
27
下载量
5
CSCD
- 网络PDF下载
- Meta-XML下载
- BibTeX下载
- Endnote下载
- RefMan 下载
- NoteExpress下载
- NoteFirst下载
关联资源
相关文章
相关作者
相关机构
- 地址：长春市经济技术开发区东南湖大路3888号 邮编：130033
- 联系电话：0431-86176862 Email：fgxbt@126.com
- 本系统由Light学术出版中心、北京北大方正电子有限公司共建 吉ICP备11002662号-17
京公网安备11010802024621 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies
