FENG Li-yun, KONG Xiang-gui. Preparation and Characterization of Fluorescence CdSe-Liposome Compound[J]. Chinese Journal of Luminescence, 2007,28(3): 417-420,
FENG Li-yun, KONG Xiang-gui. Preparation and Characterization of Fluorescence CdSe-Liposome Compound[J]. Chinese Journal of Luminescence, 2007,28(3): 417-420,DOI:
Preparation and Characterization of Fluorescence CdSe-Liposome Compound
CdSe semiconductor QDs with diameters ranging between 1.5 and 8nm exhibit strong and tunable luminescence. They have been widely investigated because of their potential use in sensors
laser materials
thin film light-emitting devices (LEDs)
and biological labels. Among numerous possible applications of CdSe nanoparticles
biological labeling will be pointed out. However
highly luminescent CdSe nanocrystals were usually synthesized with hydrophobic organic capping agents
such as trioctylphosphine/trioctylphiosphine oxide (TOP/TOPO)
which limits their applications in biology. To overcome this limitation
several synthesis strategies have been used. This work presents that hydrophobic CdSe quantum dots (QDs) were successfully transferred from nonpolar organic solvent to biocompatible water buffer by liposome encapsulating technology. And this result has been confirmed via transmission electron microscopy (TEM)
fluorescence mapping
and photoluminescence (PL)
respectively. TEM image showed free CdSe QDs are spherical and nearly monodispersed
having an average diameter of 3nm. Average size of QD-liposome is approximately 20nm. TEM images showed that QDs have been encapsulated in the liposome. Fluorescence mapping successfully showed the luminescence intensity distribution of liposome-entrapped QDs (QD-liposome). Photoluminescence indicated that QDs-Lip basically retain optics quality of free quantum. This phenomenon can be attributed to liposome transfer with TOPO molecules that stabilize the surface of QDs
via hydrophobic interaction between double molecule chain of lipid with CdSe surface on the TOPO ligand
form a bilayer structure with TOPO molecules that stabilize the surface of QDs
keep CdSe exist environment. As a result
QDs-Lip possesses high emission efficiency.
关键词
脂质体CdSe量子点生物相容性
Keywords
liposomeCdSequantum dotsbiocompatible
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