基于稀土上转换纳米荧光探针的肿瘤标志物体外检测

于莉华; 刘永升; 陈学元

doi:10.3788/fgxb20183901.0027

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基于稀土上转换纳米荧光探针的肿瘤标志物体外检测

“上转换发光材料及应用”专刊 | 更新时间：2022-09-21

- 基于稀土上转换纳米荧光探针的肿瘤标志物体外检测
- Lanthanide-doped Upconversion Nano-bioprobes for In-vitro Detection of Tumor Markers
- Chinese Journal of Luminescence 2018年39卷第1期页码：27-49
- 作者机构：
  
  1.中国科学院福建物质结构研究所，中国科学院功能纳米结构设计与组装重点实验室福建省纳米材料重点实验室，福建福州 350002
  2.福建师范大学材料科学与工程学院, 福建福州 350007
- 作者简介：
  
  [ "于莉华（1993－），女，河南漯河人，博士研究生，2016年于河南师范大学获得硕士学位，主要从事稀土纳米材料方面的研究。E-mail: lhya@fjirsm.ac.cn" ]
  [ "刘永升（1977－），男，山东临沂人，博士，研究员，2010年于中国科学院福建物质结构研究所获得博士学位，主要从事无机发光材料方面的研究。E-mail: liuysh@fjirsm.ac.cn" ]
  [ "陈学元（1970－），男，福建建瓯人，博士，研究员，1998年于中国科学院福建物质结构研究所获得博士学位，主要从事纳米发光材料方面的研究。E-mail: xchen@fjirsm.ac.cn" ]
- 基金信息：
  
  The Strategic Priority Research Program of The CAS(XDB20000000;XDA09030102);973 National Major Scientific Research Program(2014CB845605);National Natural Science Foundation of China(21771185;21473205;U1305244;21325104);CAS/SAFEA International Partnership Program for Creative Research Teams;Youth Innovation Promotion Association of CAS;Natural Science Foundation of Fujian Province(2017I0018;2017J01038)
- DOI：10.3788/fgxb20183901.0027
  中图分类号： O482.31;TP394.1
- 纸质出版日期：2018-01，
  
  收稿日期：2017-10-26，
  
  修回日期：2017-11-23，
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于莉华, 刘永升, 陈学元. 基于稀土上转换纳米荧光探针的肿瘤标志物体外检测[J]. Chinese Journal of Luminescence, 2018,39(1):27-49.

Li-hua YU, Yong-sheng LIU, Xue-yuan CHEN. Lanthanide-doped Upconversion Nano-bioprobes for In-vitro Detection of Tumor Markers[J]. 发光学报, 2018,39(1):27-49.
于莉华, 刘永升, 陈学元. 基于稀土上转换纳米荧光探针的肿瘤标志物体外检测[J]. Chinese Journal of Luminescence, 2018,39(1):27-49. DOI： 10.3788/fgxb20183901.0027.

Li-hua YU, Yong-sheng LIU, Xue-yuan CHEN. Lanthanide-doped Upconversion Nano-bioprobes for In-vitro Detection of Tumor Markers[J]. 发光学报, 2018,39(1):27-49. DOI： 10.3788/fgxb20183901.0027.

摘要

肿瘤标志物的超敏特异性检测对肿瘤患者的早期诊断和治疗以及增加其存活率具有重要的意义。作为新一代的纳米荧光探针，稀土掺杂上转换纳米晶具有独特的近红外激发的反斯托克斯上转换发光以及长荧光寿命等特征，被认为是有机染料、稀土螯合物、量子点等传统荧光探针在肿瘤早期诊疗领域最有应用前景的替代者。本文从上转换纳米荧光探针最基础的物理化学性质如控制合成、表面修饰以及发光物理出发，系统综述了该类材料在肿瘤标志物上转换体外检测方面的最新进展，并对其未来的发展趋势与努力的方向作了进一步的远景展望。

Abstract

Sensitive and specific biodetection of tumor markers is essential for early-stage cancer diagnosis and therapy

and will ultimately increase the patient survival rate. As a new generation of luminescent nano-bioprobes

trivalent lanthanide (

)-doped upconversion (UC) nanoparticles (NPs) possess exceptional properties such as near-infrared triggered anti-Stokes luminescence and long excited-state lifetime

and thus are considered to be the most promising alternative to conventional probes such as organic dyes

lanthanide chelates and quantum dots for early cancer theranostics. In this review

we provide a brief overview of the most recent advances in the development of

-doped UC nano-bioprobes

which covers from their chemical and physical fundamentals to biodetection including the controlled synthesis

surface modification

optical spectroscopy and their

vitro

UC luminescent bioassay of tumor markers. Some future prospects and challenges in this rapidly growing field are finally envisioned.

关键词

稀土上转换发光肿瘤标志物纳米晶生物检测

Keywords

lanthanide ionupconversiontumor makernanoparticlebioassay

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Highly Enhanced Upconversion Luminescence Through Partially Isolate Yb³⁺ in Core-shell-shell Structured NaYF₄: Yb³⁺, Ln³⁺@NaYF₄: Yb³⁺@NaYF₄ (Ln=Ho, Tm) Nanocrystals