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1.中国科学院 福建物质结构研究所,中国科学院功能纳米结构设计与组装重点实验室福建省纳米材料重点实验室,福建 福州 350002
2.福建师范大学 材料科学与工程学院, 福建 福州 350007
[ "于莉华(1993-),女,河南漯河人,博士研究生,2016年于河南师范大学获得硕士学位,主要从事稀土纳米材料方面的研究。E-mail: lhya@fjirsm.ac.cn" ]
[ "刘永升(1977-),男,山东临沂人,博士,研究员,2010年于中国科学院福建物质结构研究所获得博士学位,主要从事无机发光材料方面的研究。E-mail: liuysh@fjirsm.ac.cn" ]
[ "陈学元(1970-),男,福建建瓯人,博士,研究员,1998年于中国科学院福建物质结构研究所获得博士学位,主要从事纳米发光材料方面的研究。E-mail: xchen@fjirsm.ac.cn" ]
纸质出版日期:2018-01,
收稿日期:2017-10-26,
修回日期:2017-11-23,
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于莉华, 刘永升, 陈学元. 基于稀土上转换纳米荧光探针的肿瘤标志物体外检测[J]. Chinese Journal of Luminescence, 2018,39(1):27-49.
Li-hua YU, Yong-sheng LIU, Xue-yuan CHEN. Lanthanide-doped Upconversion Nano-bioprobes for
于莉华, 刘永升, 陈学元. 基于稀土上转换纳米荧光探针的肿瘤标志物体外检测[J]. Chinese Journal of Luminescence, 2018,39(1):27-49. DOI: 10.3788/fgxb20183901.0027.
Li-hua YU, Yong-sheng LIU, Xue-yuan CHEN. Lanthanide-doped Upconversion Nano-bioprobes for
肿瘤标志物的超敏特异性检测对肿瘤患者的早期诊断和治疗以及增加其存活率具有重要的意义。作为新一代的纳米荧光探针,稀土掺杂上转换纳米晶具有独特的近红外激发的反斯托克斯上转换发光以及长荧光寿命等特征,被认为是有机染料、稀土螯合物、量子点等传统荧光探针在肿瘤早期诊疗领域最有应用前景的替代者。本文从上转换纳米荧光探针最基础的物理化学性质如控制合成、表面修饰以及发光物理出发,系统综述了该类材料在肿瘤标志物上转换体外检测方面的最新进展,并对其未来的发展趋势与努力的方向作了进一步的远景展望。
Sensitive and specific biodetection of tumor markers is essential for early-stage cancer diagnosis and therapy
and will ultimately increase the patient survival rate. As a new generation of luminescent nano-bioprobes
trivalent lanthanide (
Ln
3+
)-doped upconversion (UC) nanoparticles (NPs) possess exceptional properties such as near-infrared triggered anti-Stokes luminescence and long excited-state lifetime
and thus are considered to be the most promising alternative to conventional probes such as organic dyes
lanthanide chelates and quantum dots for early cancer theranostics. In this review
we provide a brief overview of the most recent advances in the development of
Ln
3+
-doped UC nano-bioprobes
which covers from their chemical and physical fundamentals to biodetection including the controlled synthesis
surface modification
optical spectroscopy and their
in
-
vitro
UC luminescent bioassay of tumor markers. Some future prospects and challenges in this rapidly growing field are finally envisioned.
稀土上转换发光肿瘤标志物纳米晶生物检测
lanthanide ionupconversiontumor makernanoparticlebioassay
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