席夫碱稀土配合物与DNA的作用方式

李小芳; 冯小强; 杨声; 朱元成

doi:10.3788/fgxb20163707.0873

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席夫碱稀土配合物与DNA的作用方式

发光学应用及交叉前沿 | 更新时间：2020-08-12

- 席夫碱稀土配合物与DNA的作用方式
- Interaction of Schiff Base Rare Earth Complexes with Herring Sperm DNA
- 发光学报 2016年37卷第7期页码：873-880
- 作者机构：
  
  1. 天水师范学院化工学院, 甘肃天水 741001
  2. 定西师专化学系,甘肃定西,743000
- 作者简介：
- 基金信息：
  
  国家自然科学基金(51063006)();天水师范学院"();青蓝"();人才工程和中青年教师科研项目(TSA1508)资助()
- DOI：10.3788/fgxb20163707.0873
  中图分类号： O657.3
- 纸质出版日期：2016-7-5，
  
  收稿日期：2016-3-8，
  
  修回日期：2016-4-5，
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李小芳, 冯小强, 杨声等. 席夫碱稀土配合物与DNA的作用方式[J]. 发光学报, 2016,37(7): 873-880

LI Xiao-fang, FENG Xiao-qiang, YANG Sheng etc. Interaction of Schiff Base Rare Earth Complexes with Herring Sperm DNA[J]. Chinese Journal of Luminescence, 2016,37(7): 873-880
李小芳, 冯小强, 杨声等. 席夫碱稀土配合物与DNA的作用方式[J]. 发光学报, 2016,37(7): 873-880 DOI： 10.3788/fgxb20163707.0873.

LI Xiao-fang, FENG Xiao-qiang, YANG Sheng etc. Interaction of Schiff Base Rare Earth Complexes with Herring Sperm DNA[J]. Chinese Journal of Luminescence, 2016,37(7): 873-880 DOI： 10.3788/fgxb20163707.0873.

摘要

以糠醛和对氨基苯磺酸反应合成席夫碱配体

与稀土离子配位制得相应的稀土配合物

并运用光谱法研究配合物与DNA之间的作用机制

为新型抗癌药物的设计开发提供依据。采用元素分析、红外和紫外光谱对配合物性质进行表征测试

确定其化学组成为

REL

(OH)

为La

、Nd

、Eu

为去质子形式的希夫碱配体。此外

运用光谱法和循环伏安法研究了

REL

(OH)配合物与鲱鱼精DNA之间的作用方式。配合物在加入DNA后

特征吸收峰强度发生明显的减色效应

但峰位红移不明显。配合物能够猝灭中性红-DNA体系的荧光。Fe(CN)

的氧化还原峰电流在配合物加入后减小

式量电位有正移趋势

表明配合物、Fe(CN)

与DNA的作用存在竞争。研究结果表明:这3种席夫碱稀土配合物与鲱鱼精DNA的作用均属于嵌插

且含有不同稀土离子的配合物与DNA的作用强弱不同

作用大小次序为Eu配合物

La配合物

Nd配合物

席夫碱

这可能与DNA和配合物中的稀土离子所发生的作用有关。

Abstract

A new Schiff base was synthesized from furaldehyde and sulfanilic acid

and rare earth complexes of this ligand were prepared with it. The interactions of the rare earth complexes with DNA were investigated by spectroscopy method

which could provide the basis for the design and development of new anticancer drugs. The ternary complexes were characterized by elemental analysis

and UV-Vis methods. The results show that the composition of these coordinated compounds is

REL

(OH) (

=La

=deprotonated ligand of Schiff base). Meanwhile

the interaction between complexes and herring sperm DNA was investigated by cyclic voltammetry and UV-Vis spectra. The absorption intensity of herring sperm DNA decreases with the adding of complex

and the maximum absorption peak has a red shift. The peak current of probe molecule Fe(CN)

at Au/DNA electrode obviously decreases and the peak potential shifts positively because of the existences of complex. The results show that there is a competitive effect between complex and Fe(CN)

with herring sperm DNA

and a binding mode intercalation is interacted between complex and herring sperm DNA

thus leads to the change of DNA conformation.

关键词

席夫碱稀土DNA循环伏安法光谱法

Keywords

Schiff baserare earth complexDNAcyclic voltammetryspectra method

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