半导体聚合物纳米荧光探针的制备及生物应用研究进展

张佳楠; 常开文; 李琼; 孙凯; 尹升燕; 吴长锋

doi:10.3788/fgxb20153607.0725

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半导体聚合物纳米荧光探针的制备及生物应用研究进展

材料合成及性能 | 更新时间：2020-08-12

- 半导体聚合物纳米荧光探针的制备及生物应用研究进展
- Preparation, Regulation and Biological Application of Fluorescent Semiconducting Polymer Dots
- 发光学报 2015年36卷第7期页码：725-737
- 作者机构：
  
  集成光电子学国家重点联合实验室吉林大学实验区吉林大学电子科学与工程学院,吉林长春,130012
- 作者简介：
- 基金信息：
  
  国家自然科学优秀青年基金(61222508)();国家自然科学重点基金(61335001)资助项目()
- DOI：10.3788/fgxb20153607.0725
  中图分类号： O631;O482.31
- 纸质出版日期：2015-7-3，
  
  收稿日期：2015-4-19，
  
  修回日期：2015-5-16，
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张佳楠, 常开文, 李琼等. 半导体聚合物纳米荧光探针的制备及生物应用研究进展[J]. 发光学报, 2015,36(7): 725-737

ZHANG Jia-nan, CHANG Kai-wen, LI Qiong etc. Preparation, Regulation and Biological Application of Fluorescent Semiconducting Polymer Dots[J]. Chinese Journal of Luminescence, 2015,36(7): 725-737
张佳楠, 常开文, 李琼等. 半导体聚合物纳米荧光探针的制备及生物应用研究进展[J]. 发光学报, 2015,36(7): 725-737 DOI： 10.3788/fgxb20153607.0725.

ZHANG Jia-nan, CHANG Kai-wen, LI Qiong etc. Preparation, Regulation and Biological Application of Fluorescent Semiconducting Polymer Dots[J]. Chinese Journal of Luminescence, 2015,36(7): 725-737 DOI： 10.3788/fgxb20153607.0725.

摘要

半导体聚合物作为功能有机高分子材料被广泛应用于有机光电子器件领域的研究。近年来由半导体聚合物构成的荧光纳米粒子引起了广泛的研究兴趣。这类新型纳米探针具有光学吸收截面大、量子效率高、辐射跃迁速率快、光稳定性好等特性

在荧光成像和生物传感等领域获得了重要应用。本文简要概述了近年来半导体聚合物纳米粒子的研究进展

包括其光物理性质、表面功能化以及在细胞标记、体内成像、生物传感、单粒子示踪、药物输送和光动力学疗法等领域的应用。

Abstract

In recent years

fluorescent semiconducting polymer nanoparticles

which primarily consist of -conjugated polymers

have been attracted considerable attention in an extensive range of applications

such as fluorescence imaging and biosensing. These -conjugated polymer nanoparticles are called polymer dots (Pdots) when they have particle size comparable to that of the inorganic quantum dots. Pdots have many charming properties

such as large absorption cross section

high fluorescence quantum yield

very fast emission rates

excellent photostability

and so on. In this review

we briefly summarize recent findings of the photophysical properties of Pdots

the surface functionalization and biomolecular conjugation of Pdots and their applications in cellular labeling

in vivo

imaging

biosensing

single-particle tracking

drug delivery and photodynamic therapy.

关键词

半导体聚合物量子点荧光探针单粒子示踪生物成像

Keywords

semiconducting polymerquantum dotsfluorescent probessingle particle trackingbiological imaging

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