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河北大学化学与环境科学学院 河北省分析科学技术重点实验室,河北 保定,071002
纸质出版日期:2015-6-3,
收稿日期:2015-3-27,
修回日期:2015-4-22,
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李改霞, 刘保生, 李志云等. 盐酸吡格列酮与BSA反应机理的荧光猝灭法、同步荧光法比较研究[J]. 发光学报, 2015,36(6): 705-710
LI Gai-xia, LIU Bao-sheng, LI Zhi-yun etc. Comparative Studies on The Reaction Mechanism of Pioglitazone Hydrochloride with Bovine Serum Albumin by Fluorescence Spectroscopy and Synchronous Fluorescence Spectroscopy[J]. Chinese Journal of Luminescence, 2015,36(6): 705-710
李改霞, 刘保生, 李志云等. 盐酸吡格列酮与BSA反应机理的荧光猝灭法、同步荧光法比较研究[J]. 发光学报, 2015,36(6): 705-710 DOI: 10.3788/fgxb20153606.0705.
LI Gai-xia, LIU Bao-sheng, LI Zhi-yun etc. Comparative Studies on The Reaction Mechanism of Pioglitazone Hydrochloride with Bovine Serum Albumin by Fluorescence Spectroscopy and Synchronous Fluorescence Spectroscopy[J]. Chinese Journal of Luminescence, 2015,36(6): 705-710 DOI: 10.3788/fgxb20153606.0705.
利用荧光猝灭法和同步荧光法进行了盐酸吡格列酮(PGH)与牛血清白蛋白(BSA)之间反应机理的比较研究。结果表明:两种方法在研究PGH-BSA体系的猝灭类型、结合常数、结合位置、作用力类型、协同性及能量转移距离等方面
得到了相同的结果
表明同步荧光光谱法可以用于药物与蛋白反应机理的研究。
The reaction mechanism between pioglitazone hydrochloride (PGH) and bovine serum albumin (BSA) was studied by fluorescence quenching method and synchronous fluorescence method under different temperatures. The results show that the conclusions of two methods are identical on the quenching mechanism
type of interaction force
binding constants
binding location
synergistic effect
energy-transfer parameters of pioglitazone hydrochloride with bovine serum albumin
etc
. These indicate that the synchronous fluorescence spectroscopy can be used to replace the traditional fluorescence spectroscopy to study the reaction mechanism of drugs with protein.
荧光猝灭法同步荧光法盐酸吡格列酮牛血清白蛋白反应机理
fluorescence spectroscopysynchronous fluorescence spectroscopypioglitazone hydrochloridebovine serum albuminreaction mechanism
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