比率型碳点荧光传感器检测机理与应用研究进展

李庆芝; 周奕华; 陈袁; 陆菲; 钱俊; 曹晟

doi:10.3788/fgxb20204105.0579

您当前的位置：

首页 >

文章列表页 >

比率型碳点荧光传感器检测机理与应用研究进展

器件制备及器件物理 | 更新时间：2020-09-21

- 比率型碳点荧光传感器检测机理与应用研究进展
- Research Progress on Detection Mechanism and Application of Carbon Dots-based Ratiometric Fluorescence Sensor
- 发光学报 2020年41卷第5期页码：579-591
- 作者机构：
  
  1.武汉大学印刷与包装系, 湖北武汉 430279
  2.武汉东湖学院, 湖北武汉 430212
- 作者简介：
  
  [ "李庆芝(1997-), 女, 山西阳泉人, 硕士研究生, 2019年于天津科技大学获得学士学位, 主要从事碳量子点检测方面的研究。E-mail:lqzhi0927@163.com" ]
  [ "周奕华(1974-), 女, 河北张家口人, 博士, 副教授, 2007年于武汉大学获得博士学位, 主要从事喷墨打印、CDs制备与应用和纸基检测的研究。E-mail:yihuazhou@whu.edu.cn" ]
- 基金信息：
  
  湖北省自然科学基金(2017CFC888);国家自然科学基金(51371129);国家自然科学基金(11174226)
- DOI：10.3788/fgxb20204105.0579
  中图分类号： O482.31
- 纸质出版日期：2020-5，
  
  收稿日期：2020-3-6，
  
  录用日期：2020-3-27
扫描看全文
李庆芝, 周奕华, 陈袁, 等. 比率型碳点荧光传感器检测机理与应用研究进展[J]. 发光学报, 2020,41(5):579-591.

Qing-zhi LI, Yi-hua ZHOU, Yuan CHEN, et al. Research Progress on Detection Mechanism and Application of Carbon Dots-based Ratiometric Fluorescence Sensor[J]. Chinese Journal of Luminescence, 2020,41(5):579-591.
李庆芝, 周奕华, 陈袁, 等. 比率型碳点荧光传感器检测机理与应用研究进展[J]. 发光学报, 2020,41(5):579-591. DOI： 10.3788/fgxb20204105.0579.

Qing-zhi LI, Yi-hua ZHOU, Yuan CHEN, et al. Research Progress on Detection Mechanism and Application of Carbon Dots-based Ratiometric Fluorescence Sensor[J]. Chinese Journal of Luminescence, 2020,41(5):579-591. DOI： 10.3788/fgxb20204105.0579.

摘要

比率型荧光传感器由于具有抗干扰能力强和灵敏度高等优点，在食品安全、金属离子检测、环境污染分析等许多领域显示出巨大的应用潜力。而碳点作为一种新型荧光材料，不仅具有优良的荧光性能，而且毒性低、易于表面功能化，非常适合构建比率型荧光传感器。本文就近年来比率型碳点荧光传感器在检测领域的研究进展进行综述，重点阐述了碳点的荧光检测机理，并根据碳点使用情况的不同，对不同类型的比率型碳点荧光传感器进行了分类总结。最后提出了该领域亟待解决的困难和问题，并对其在分析物检测方面的发展方向进行了展望。

Abstract

Ratiometric fluorescence sensors have shown great application potential in fields of food safety

metal ion detection

environmental pollution analysis

etc

due to its strong anti-interference ability and high sensitivity. As a new fluorescent material

carbon dots (CDs) have excellent photoluminescence property and low toxicity and the surface is easy to be functionalized

which have become a good choice to build ratiometic fluorescent sensor. In this paper

the recent research progresses of CDs-based ratiometric fluorescence sensor in the detection field are reviewed

and the fluorescence mechanism of carbon dots is mainly outlined. The CDs-based ratiometric fluorescence sensors are classified and summarized based on different applications of carbon dots. Finally

the difficulties and problems to be overcome in this field are put forward

and the development direction of the application of CDs-based ratiometric fluorescence sensor for analytic detection is prospected.

关键词

比率型传感器碳点检测机理可视化检测

Keywords

ratiometric sensorcarbon dotsdetection mechanismvisual detection

references

LU H Z, QUAN S, XU S F. Highly sensitive ratiometric fluorescent sensor for trinitrotoluene based on the inner filter effect between gold nanoparticles and fluorescent nanoparticles[J].J. Agric. Food. Chem., 2017, 65(44):9807-9814.

XU H Y, ZHANG K N, LIU Q S, et al.. Visual and fluorescent detection of mercury ions by using a dually emissive ratiometric nanohybrid containing carbon dots and CdTe quantum dots[J].Microchim. Acta, 2017, 184(4):1199-1206.

LEE M H, KIM J S, SESSLER J L. Small molecule-basedratiometric fluorescence probes for cations, anions, and biomolecules[J].Chem. Soc. Rev., 2015, 44(13):4185-4191.

BIGDELI A, GHASEMI F, ABBASI-MOAYED S, et al.. Ratiometric fluorescent nanoprobes for visual detection:design principles and recent advances-a review[J].Anal. Chim. Acta, 2019, 1079:30-58.

XU X Y, RAY R, GU Y L, et al.. Electrophoretic analysis and purification of fluorescent single-walled carbon nanotube fragments[J].J. Amer. Chem. Soc., 2004, 126(40):12736-12737.

SUN Y P, ZHOU B, LIN Y, et al.. Quantum-sized carbon dots for bright and colorful photoluminescence[J].J. Amer. Chem. Soc., 2006, 128(24):7756-7757.

ZUO P L, LU X H, SUN Z G, et al.. A review on syntheses, properties, characterization and bioanalytical applications of fluorescent carbon dots[J].Microchim. Acta, 2015, 183(2):519-542.

YAN F Y, SUN Z H, ZHANG H, et al.. The fluorescence mechanism of carbon dots, and methods for tuning their emission color:a review[J].Mikrochim. Acta, 2019, 186(8):583-1-37.

唐志姣, 李攻科, 胡玉玲.荧光碳点在分析检测中的研究进展[J].分析测试学报, 2015, 34(8):970-978.

TANG Z J, LI G K, HU Y L. Progress on fluorescent carbon dots in analysis[J].J. Instrum. Anal., 2015, 34(8):970-978. (in Chinese)

张卜, 哈丽丹·买买提, 张云飞, 等.荧光碳点的研究综述[J].现代化工, 2017, 37(10):43-47.

ZHANG B, HALIDAN M M T, ZHANG Y F, et al.. Research overview on fluorescent carbon dots[J].Mod. Chem. Ind., 2017, 37(10):43-47. (in Chinese)

LIU H C, DING J, ZHANG K, et al.. Construction of biomass carbon dots based fluorescence sensors and their applications in chemical and biological analysis[J].TrAC Trends Anal. Chem., 2019, 118:315-337.

LIU C, NING D H, ZHANG C, et al.. Dual-colored carbon dot ratiometric fluorescent test paper based on a specific spectral energy transfer for semiquantitative assay of copper ions[J].ACS Appl. Mater. Interfaces, 2017, 9(22):18897-18903.

LU F, ZHOU Y H, WU L H, et al.. Highly fluorescent nitrogen-doped graphene quantum dots' synthesis and their applications as Fe(Ⅲ) ions sensor[J].Int. J. Opt., 2019, 2019:8724320-1-9.

JIN H, GUI R J, WANG Y F, et al.. Carrot-derived carbon dots modified with polyethyleneimine and nile blue for ratiometric two-photon fluorescence turn-on sensing of sulfide anion in biological fluids[J].Talanta, 2017, 169:141-148.

WEI Z N, LI H Q, LIU S B, et al.. Carbon dots as fluorescent/colorimetric probes for real-time detection of hypochlorite and ascorbic acid in cells and body fluid[J].Anal. Chem., 2019, 91(24):15477-15483.

CHATZIMITAKOS T, KASOUNI A, SYGELLOU L, et al.. Human fingernails as an intriguing precursor for the synthesis of nitrogen and sulfur-doped carbon dots with strong fluorescent properties:analytical and bioimaging applications[J].Sens. Actuators B:Chem., 2018, 267:494-501.

HUANG Y, CHENG Z J. Simple and green synthesis of boron-, sulfur-, and nitrogen-co-doped carbon dots as fluorescent probe for selective and sensitive detection of sunset yellow[J].Nano, 2017, 12(10):1750123.

PAN X H, ZHANG Y, SUN X B, et al.. A green emissive carbon-dot-based sensor with diverse responsive manners for multi-mode sensing[J].Analyst, 2018, 143(23):5812-5821.

XU H, YANG X P, LI G, et al.. Green synthesis of fluorescent carbon dots for selective detection of tartrazine in food samples[J].J. Agric. Food Chem., 2015, 63(30):6707-6714.

LI B L, LI Y S, GAO X F. Fluorescence quenching capillary analysis for determining trace-level nitrite in food based on the citric acid/ethylenediamine nanodots/nitrite reaction[J].Food Chem., 2019, 274:162-169.

XIANG G Q, WANG Y L, ZHANG H, et al.. Carbon dots based dual-emission silica nanoparticles as ratiometric fluorescent probe for nitrite determination in food samples[J].Food Chem., 2018, 260:13-18.

DAI H C, SHI Y, WANG Y L., et al.. A carbon dot based biosensor for melamine detection by fluorescence resonance energy transfer[J].Sens. Actuators B:Chem., 2014, 202:201-208.

LI N, LIU T, LIU S G, et al.. Visible and fluorescent detection of melamine in raw milk with one-step synthesized silver nanoparticles using carbon dots as the reductant and stabilizer[J].Sens. Actuators B:Chem., 2017, 248:597-604.

LIU J S, WANG L Z, BAO H J. A novel fluorescent probe for ascorbic acid based on seed-mediated growth of silver nanoparticles quenching of carbon dots fluorescence[J].Anal. Bioanal. Chem., 2019, 411(4):877-883.

ZHANG L M, QIN J, YANG Q, et al.. Redox modulated fluorometric sensing of ascorbic acid by using a hybrid material composed of carbon dots and CoOOH nanosheets[J].Microchim. Acta, 2019, 186(6):368-1-7.

YU J J, YUAN K, LI X, et al.. Selective detection for seven kinds of antibiotics with blue emitting carbon dots and Al3+ ions[J].Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 2019, 223:117366.

WANG L, BI Y D, HOU J, et al.. Facile, green and clean one-step synthesis of carbon dots from wool:application as a sensor for glyphosate detection based on the inner filter effect[J].Talanta, 2016, 160:268-275.

HOU J Y, DONG G J, TIAN Z B, et al.. A sensitive fluorescent sensor for selective determination of dichlorvos based on the recovered fluorescence of carbon dots-Cu(Ⅱ) system[J].Food Chem., 2016, 202:81-87.

HUANG S, YAO J D, CHU X, et al.. One-step facile synthesis of nitrogen-doped carbon dots:a ratiometric fluorescent probe for evaluation of acetylcholinesterase activity and detection of organophosphorus pesticides in tap water and food[J].J. Agric. Food Chem., 2019, 67(40):11244-11255.

LI H X, YAN X, LU G Y, et al.. Carbon dot-based bioplatform for dual colorimetric and fluorometric sensing of organophosphate pesticides[J].Sens. Actuators B:Chem., 2018, 260:563-570.

LIU D Y, QU F, ZHAO X E, et al.. Generalized one-pot strategy enabling different surface functionalizations of carbon nanodots to produce dual emissions in alcohol-water binary systems[J].J. Phys. Chem. C, 2015, 119(31):17979-17987.

NIE H, LI M J, LI Q S, et al.. Carbon dots with continuously tunable full-color emission and their application in ratiometric pH sensing[J].Chem. Mater., 2014, 26(10):3104-3112.

ZHANG T Y, DONG S, ZHAO F F, et al.. Tricolor emissive carbon dots for ultra-wide range pH test papers and bioimaging[J].Sens. Actuators B:Chem., 2019, 298:126869.

WEN Z Q, SONG S L, HU T T, et al.. A dual emission nanocomposite prepared from copper nanoclusters and carbon dots as a ratiometric fluorescent probe for sulfide and gaseous H2S[J].Microchim. Acta, 2019, 186(4):258-1-8.

YAN Y H, ZHANG K, YU H, et al.. Sensitive detection of sulfide based on the self-assembly of fluorescent silver nanoclusters on the surface of silica nanospheres[J].Talanta, 2017, 174:387-393.

颜范勇, 邹宇, 王猛, 等.荧光碳点的制备及应用[J].化学进展, 2014, 26(1):61-74.

FAN F Y, ZOU Y, WANG M, et al.. Synthesis and application of the fluorescent carbon dots[J].Prog. Chem., 2014, 26(1):61-74. (in Chinese)

ZHI B, YAO X X, CUI Y, et al.. Synthesis, applications and potential photoluminescence mechanism of spectrally tunable carbon dots[J].Nanoscale, 2019, 11(43):20411-20428.

ZHU S J, SONG Y B, ZHAO X H, et al.. The photoluminescence mechanism in carbon dots (graphene quantum dots, carbon nanodots, and polymer dots):current state and future perspective[J].Nano Res., 2015, 8(2):355-381.

PRATHUMSUWAN T, JAIYONG P, IN I, et al.. Label-free carbon dots from water hyacinth leaves as a highly fluorescent probe for selective and sensitive detection of borax[J].Sens. Actuators B:Chem., 2019, 299:126936.

王宁, 石璟, 张育露, 等.氮掺杂碳点为荧光探针检测高锰酸根[J].分析试验室, 2020, 39:doi:10.13595/j.cnki.issn1000-0720.2019.090701.

WANG N, SHI J, ZHANG Y L, et al.. Nitrogen-doped carbon dots used as a fluorescent probe to detect MnO4-[J].Chin. J. Anal. Lab., 2020, 39:doi:10.13595/j.cnki.issn1000-0720.2019.090701.(in Chinese)

CHATZIMITAKOS T G, STALIKAS C D. Carbonnanodots from natural (re)sources:a new perspective on analytical chemistry[M]. HUSSAIN C M.Handbook of Nanomaterials in Analytical Chemistry, Amsterdam:Elsevier, 2020:3-28.

CHEN Q, ZHU P P, XIONG J, et al.. A new dual-recognition strategy for hybrid ratiometric and ratiometric sensing perfluorooctane sulfonic acid based on high fluorescent carbon dots with ethidium bromide[J].Spectrochim. Acta Part A:Mol. Biomol. Spectrosc., 2020, 224:117362.

LIU M Y, GAO Z, YU Y J, et al.. Molecularly imprinted core-shell CdSe@SiO2/CDs as a ratiometric fluorescent probe for 4-nitrophenol sensing[J].Nanoscale Res. Lett., 2018, 13(1):27-1-9.

李宏, 赵纯希, 王翰墨, 等.氮硫掺杂荧光碳点测定菇类食品中维生素B2的研究[J].分析科学学报, 2019, 35(4):449-454.

LI H, ZHAO C X, WANG H M, et al.. Determination of vitamin B2 in mushrooms by nitrogen and sulfur co-doped fluorescent carbon dots[J].J. Anal. Sci., 2019, 35(4):449-454. (in Chinese)

MAO Y J, ZHANG Y, HU W, et al.. Carbon dots-modified nanoporous membrane and Fe3O4@Au magnet nanocomposites-based FRET assay for ultrasensitive histamine detection[J].Molecules, 2019, 24(17):3039-1-12.

DONG B L, LI H F, MUJTABA MARI G, et al.. Fluorescence immunoassay based on the inner-filter effect of carbon dots for highly sensitive amantadine detection in foodstuffs[J].Food Chem., 2019, 294:347-354.

LIU X Q, WANG T, WANG W J, et al.. A tailored molecular imprinting ratiometric fluorescent sensor based on red/blue carbon dots for ultrasensitive tetracycline detection[J].J. Ind. Eng. Chem., 2019, 72:100-106.

JALILI R, KHATAEE A, RASHIDI M R, et al.. Dual-colored carbon dot encapsulated metal-organic framework for ratiometric detection of glutathione[J].Sens. Actuators B:Chem., 2019, 297:126775.

JIANG X W, JIN H, SUN Y J, et al.. Colorimetric and fluorometric dual-channel ratiometric determination of fungicide cymoxanil based on analyte-induced aggregation of silver nanoparticles and dually emitting carbon dots[J].Microchim. Acta, 2019, 186(8):580-1-12.

SONG W, DUAN W X, LIU Y H, et al.. Ratiometric detection of intracellular lysine and pH with one-pot synthesized dual emissive carbon dots[J].Anal. Chem., 2017, 89(24):13626-13633.

NGUYEN V, YAN L H, XU H H, et al.. One-step synthesis of multi-emission carbon nanodots for ratiometric temperature sensing[J].Appl. Surf. Sci., 2018, 427:1118-1123.

YAN Y H, SUN J, ZHANG K, et al.. Visualizing gaseous nitrogen dioxide by ratiometric fluorescence of carbon nanodots-quantum dots hybrid[J].Anal. Chem., 2015, 87(4):2087-2093.

ZHOU Y J, HUANG X Y, LIU C, et al.. Color-multiplexing-based fluorescent test paper:dosage-sensitive visualization of arsenic(Ⅲ) with discernable scale as low as 5 ppb[J]. Anal. Chem., 2016, 88(12):6105-6109.

RONG M C, DENG X Z, CHI S T, et al.. Ratiometric fluorometric determination of the anthrax biomarker 2, 6-dipicolinic acid by using europium(Ⅲ)-doped carbon dots in a test stripe[J].Microchim. Acta, 2018, 185(3):201-1-10.

HE W J, GUI R J, JIN H, et al.. Ratiometric fluorescence and visual imaging detection of dopamine based on carbon dots/copper nanoclusters dual-emitting nanohybrids[J].Talanta, 2018, 178:109-115.

YU C M, LI X Z, ZENG F, et al.. Carbon-dot-based ratiometric fluorescent sensor for detecting hydrogen sulfide in aqueous media and inside live cells[J].Chem. Commun., 2013, 49(4):403-405.

YAN F Y, BAI Z J, CHEN Y, et al.. Ratiometric fluorescent detection of copper ions using coumarin-functionalized carbon dots based on FRET[J].Sens. Actuators B:Chem., 2018, 275:86-94.

HU J, YANG X F, PENG Q Q, et al.. A highly sensitive visual sensor for tetracycline in food samples by a double-signal response fluorescent nanohybrid[J].Food Control, 2020, 108:106832.

GUO L L, SONG Y H, CAI K Y, et al.. "On-off" ratiometric fluorescent detection of Hg2+ based on N-doped carbon dots-rhodamine B@TAPT-DHTA-COF[J].Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 2020, 227:117703.

DONG Y Q, CAI J H, FANG Q Q, et al.. Dual-emission of lanthanide metal-organic frameworks encapsulating carbon-based dots for ratiometric detection of water in organic solvents[J].Anal. Chem., 2016, 88(3):1748-1752.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

深红至近红外碳点光热特性研究进展

氮、硫掺杂具有聚集诱导发光绿色碳点的制备与表征

绿茶衍生碳点用于光动力治疗耐药菌感染

碳点的功能化研究进展

一种比色/荧光增强型碳点基纳米探针用于环境中苯硫酚的高选择性检测