NaYF4:Yb3+, Er3+发光上转换纳米晶的 表面修饰及其生物效应

宋凯; 杜创; 赵军伟; 孔祥贵

doi:10.3788/fgxb20123311.1215

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NaYF₄:Yb³⁺, Er³⁺发光上转换纳米晶的表面修饰及其生物效应

材料合成及性能研究 | 更新时间：2020-08-12

- NaYF₄:Yb³⁺, Er³⁺发光上转换纳米晶的表面修饰及其生物效应
- Surface Modification of NaYF₄:Yb³⁺, Er³⁺ Luminescent Upconversion Nanocrystals and Biological Effects
- 发光学报 2012年33卷第11期页码：1215-1218
- 作者机构：
  
  1. 发光学与应用国家重点实验室中国科学院长春光学精密机械与物理研究所,吉林长春,130033
  2. 长春师范学院生命科学学院,吉林长春,130032
- 作者简介：
- 基金信息：
  
  国家自然科学基金(11204021,11004189,61275202)();吉科教合字[2012]第227号();长春师范学院自然合字[2010]002号资助项目()
- DOI：10.3788/fgxb20123311.1215
  中图分类号： O433.4
- 纸质出版日期：2012-11-10，
  
  收稿日期：2012-8-17，
  
  修回日期：2012-9-24，
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宋凯, 杜创, 赵军伟, 孔祥贵. NaYF4:Yb3+, Er3+发光上转换纳米晶的表面修饰及其生物效应[J]. 发光学报, 2012,(11): 1215-1218

SONG Kai, DU Chuang, ZHAO Jun-wei, KONG Xiang-gui. Surface Modification of NaYF4:Yb3+, Er3+ Luminescent Upconversion Nanocrystals and Biological Effects[J]. Chinese Journal of Luminescence, 2012,(11): 1215-1218
宋凯, 杜创, 赵军伟, 孔祥贵. NaYF4:Yb3+, Er3+发光上转换纳米晶的表面修饰及其生物效应[J]. 发光学报, 2012,(11): 1215-1218 DOI： 10.3788/fgxb20123311.1215.

SONG Kai, DU Chuang, ZHAO Jun-wei, KONG Xiang-gui. Surface Modification of NaYF4:Yb3+, Er3+ Luminescent Upconversion Nanocrystals and Biological Effects[J]. Chinese Journal of Luminescence, 2012,(11): 1215-1218 DOI： 10.3788/fgxb20123311.1215.

摘要

不理想的发光上转换纳米晶(UCNPs)表面效应成为其生物标记的主要障碍。本文合成了表面带有氨基功能基团的水溶性NaYF

:Yb

UCNPs

并通过共价偶联的方式将聚乙二醇(PEG)分子修饰到其表面。光谱测试表明纳米晶的发光性质基本没有变化

扫描电镜结果说明修饰的PEG分子在一定程度上减少了纳米晶的聚集。最后

细胞毒性实验证明这种修饰后的上转换纳米晶具有良好的生物相容性。

Abstract

Undesirable surface effect of luminescent upconversion nanoparticles (UCNPs) is a major obstacle to the biomarker. In this work

we synthesized the water-soluble NaYF

:Yb

UCNPs with amino functional groups and polyethylene glycol (PEG) molecules modified by covalent coupling of the way to the surface of UCNPs. The spectral characterization showed that the luminescent properties of UCNPs unchanged. Scanning electron microscopy results indicate that modification of PEG molecules distinctly reduce the aggregation of UCNPs. The cell toxicity experiments show that this modification on the UCNPs has good biocompatibility.

关键词

发光上转换纳米晶聚乙二醇表面修饰

Keywords

luminescent upconversion nanoparticlespolyethylene glycolsurface modification

references

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Lu Z H, Chen H, He C F, et al. Synthesis of water soluble upconversion NaYF4:Yb3+,Er3+nanoparticals using polyvinylpyrrolidone as surfactant and their biological compatibility [J]. Chin. J. Lumin.(发光学报),2011, 32(10):993-997 (in Chinese).

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