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1.上海大学理学院 纳米科学与技术研究中心, 上海 200444
2.上海大学理学院 化学系, 上海 200444
3.上海大学 纳米化学与生物学研究所, 上海 200444
[ "涂港(1997-),男,湖北荆州人,硕士研究生,2019年于湖北大学获得学士学位,主要从事稀土上转换铋纳米体系的研究。Email: tugang@shu.edu.cnt" ]
[ "施利毅(1963-),男,上海人,博士,教授,博士生导师,1999年于华东理工大学获得博士学位,主要从事纳米功能材料形态结构控制及工业化制备和应用技术的研究。" ]
[ "孙丽宁( 1979-),女,山东威海人,博士,教授/研究员,博士生导师, 2008 年于中国科学院长春应用化学研究所获得博士学位,主要从事稀土发光纳米材料及其生物成像和治疗、稀土杂化多功能材料及其发光机理、防伪和检测应用的研究。" ]
纸质出版日期:2022-07-05,
收稿日期:2022-04-18,
修回日期:2022-04-28,
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涂港,凌丹萍,刘杰等.用作近红外光引导的化学‑光热协同治疗的上转换‑铋纳米诊疗剂[J].发光学报,2022,43(07):1040-1051.
TU Gang,LING Dan-ping,LIU Jie,et al.Upconversion-bismuth Nanosystem as Theranostic Agent for NIR Laser-driven Chemo-photothermal Therapy[J].Chinese Journal of Luminescence,2022,43(07):1040-1051.
涂港,凌丹萍,刘杰等.用作近红外光引导的化学‑光热协同治疗的上转换‑铋纳米诊疗剂[J].发光学报,2022,43(07):1040-1051. DOI: 10.37188/CJL.20220142.
TU Gang,LING Dan-ping,LIU Jie,et al.Upconversion-bismuth Nanosystem as Theranostic Agent for NIR Laser-driven Chemo-photothermal Therapy[J].Chinese Journal of Luminescence,2022,43(07):1040-1051. DOI: 10.37188/CJL.20220142.
设计并合成了一种用于近红外光驱动的化学⁃光热治疗的上转换⁃铋纳米体系诊疗剂(UBDAs),其具有出色的光热转换能力(28.5%)和良好的生物相容性。同时,在980 nm近红外光的激发下,UBDAs能够发射紫外/可见光,用于促进光敏剂偶氮苯在介孔中的连续旋转⁃翻转运动,从而实现药物的可控释放,且利用近红外光激发能够有效避免传统紫外光对生物组织的副作用。光热实验表明,UBDAs杂化纳米体系在980 nm激光照射下具有良好的光热效应。此外,含有Tm
3+
和Bi元素的UBDAs有望用于上转换发光成像和X射线计算机断层成像,进而实现双模成像介导且单一近红外光激发的癌症化学疗法和光热疗法。该研究结果为诊断和协同增强抗肿瘤治疗的综合研究提供了新的思路。
A hybrid nanosystem of upconversion-bismuth integration(denoted as UBDAs) is designed and synthesized for near infrared(NIR) light-driven chemo-photothermal therapy. The obtained UBDAs present excellent photothermal conversion capacity (~28.5%) and good biocompatibility. Meanwhile, under excitation of NIR, UBDAs can emit ultraviolet/visible light, which promotes the continuous rotation-flip movement of the photosensitizer azobenzene in the mesoporous, thereby achieving the controlled drug release and avoiding the side effects of traditional ultraviolet light excitation on biological tissues. Photothermal experiments show that UBDAs hybrid nanosystems have a good photothermal effect under 980 nm laser irradiation. In addition, based on Tm
3+
and Bi element the UBDAs are expected to be used in upconversion luminescence and X-ray computed tomography(CT) imaging to achieve dual-mode imaging-mediated and single NIR-driven chemotherapy and photothermal therapy. Therefore, this work provides a new idea for the integration of diagnosis and synergistically enhanced antitumor therapy.
上转换发光成像光热治疗药物释放杂化纳米体系
upconversion luminescenceimagingphotothermal therapydrug releasehybrid nanosystems
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