纳米材料在肿瘤光热治疗中存在的问题及解决策略

常梦宇; 王曼; 侯智尧; 林君

doi:10.37188/CJL.20220118

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纳米材料在肿瘤光热治疗中存在的问题及解决策略

封面文章 | 更新时间：2022-08-01

- 纳米材料在肿瘤光热治疗中存在的问题及解决策略
  增强出版
- Problems and Solutions of Nanomaterials in Antitumor Photothermal Therapy
- 发光学报 2022年43卷第7期页码：995-1013
- 作者机构：
  
  1.中国科学院长春应用化学研究所稀土资源利用国家重点实验室，吉林长春　130022
  2.南洋理工大学物理与数学科学学院，新加坡　637371
  3.广州医科大学基础医学院，广东广州　511436
- 作者简介：
  
  [ "常梦宇（1994-），女，辽宁沈阳人，博士，2021年于中国科学院长春应用化学研究所获得博士学位，主要从事基于纳米材料的光热治疗的研究。 E-mail： mengyu.chang@ntu.edu.sg" ]
  [ "侯智尧（1980-），男，黑龙江哈尔滨人，博士，教授，2009年于哈尔滨工程大学获得博士学位，主要从事基于纳米光能转换材料构建及其抗肿瘤协同治疗的研究。 E-mail： zyhou@gzhmu.edu.cn" ]
  [ "林君（1966-），男，吉林长春人，博士，研究员，博士生导师，1995年于中国科学院化学研究所获得博士学位，主要从事稀土发光、纳米医学等的研究。 E-mail： jlin@ciac.ac.cn" ]
- 基金信息：
  
  国家自然科学基金(52072082;51929201;51672268;51720105015;51972138;51872263;51828202);吉林省科技发展规划项目(20190201232JC;20210402046GH)
- DOI：10.37188/CJL.20220118
  中图分类号： O482.31
- 纸质出版日期：2022-07-05，
  
  收稿日期：2022-04-02，
  
  修回日期：2022-04-20，
- 稿件说明：
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常梦宇,王曼,侯智尧等.纳米材料在肿瘤光热治疗中存在的问题及解决策略[J].发光学报,2022,43(07):995-1013

CHANG Meng-yu,WANG Man,HOU Zhi-yao,et al.Problems and Solutions of Nanomaterials in Antitumor Photothermal Therapy[J].Chinese Journal of Luminescence,2022,43(07):995-1013.
常梦宇,王曼,侯智尧等.纳米材料在肿瘤光热治疗中存在的问题及解决策略[J].发光学报,2022,43(07):995-1013 DOI： 10.37188/CJL.20220118.

CHANG Meng-yu,WANG Man,HOU Zhi-yao,et al.Problems and Solutions of Nanomaterials in Antitumor Photothermal Therapy[J].Chinese Journal of Luminescence,2022,43(07):995-1013. DOI： 10.37188/CJL.20220118.

摘要

由于其非侵入性、时空可控性和高效性，光热治疗（PTT）在抗肿瘤治疗领域迅猛发展。然而，PTT存在的一些问题阻碍了其进一步的临床转化。鉴于此，本文首先简要介绍了光热转换原理和PTT抗肿瘤机制。随后着重总结了PTT在发展过程中遇到的问题和不足，并列举了相应的解决策略，主要包括：调控纳米材料的形貌、构建异质结结构、选择合适的光学窗口来提高纳米材料的光热转换效率；设计多模态协同治疗模式来克服单一PTT的局限性；提高纳米材料的肿瘤富集量来增强抗癌治疗效果；以及构建肿瘤微环境激活的光热转换试剂和设计低温PTT模式来提高纳米药物的生物安全性。最后，对PTT的未来前景和发展进行了展望。

Abstract

Photothermal therapy（PTT） is developing rapidly in the field of antitumor therapy， due to its non-invasiveness， spatiotemporal controllability， and high efficiency. However， there are some practical problems in PTT， which hinder its further transition from basic scientific research to clinical applications. Herein， at first， this review briefly introduces the photothermal conversion principle and antitumor mechanism of PTT. Then， the main problems in the development of PTT are summarized， and those corresponding solutions are listed， including： enhancing the photothermal conversion efficiency by the control of nanomaterial morphology， the construction of heterojunction structures， and the adjustment of optical windows； overcoming the limitation of single PTT by the invention of collaborative treatment models； consolidating antitumor therapy effect by increasing tumor enrichment of nanomaterials； improving the biological safety of nanomedicine by the design of tumor microenvironment-activated photothermal complex and the realization of mild PTT. Finally， the future prospect and development of PTT are stated.

关键词

光热治疗光热转换效率协同治疗肿瘤微环境激活治疗低温热疗

Keywords

photothermal therapyphotothermal conversion efficiencycollaborative therapytumor microenvironment-activated therapymild photothermal therapy

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