适用于近红外荧光/核磁双模成像的GdF3∶Nd3+,Yb3+@NaGdF4纳米材料

何旭; 吴亚楠; 蒋越宁; 刘景涛; 向先兴; 文成旭; 李旭; 王凤和

doi:10.37188/CJL.20210391

您当前的位置：

首页 >

文章列表页 >

适用于近红外荧光/核磁双模成像的GdF₃∶Nd³⁺,Yb³⁺@NaGdF₄纳米材料

材料合成及性能 | 更新时间：2022-04-07

- 适用于近红外荧光/核磁双模成像的GdF₃∶Nd³⁺,Yb³⁺@NaGdF₄纳米材料
  增强出版
- GdF₃∶Nd³⁺,Yb³⁺@NaGdF₄ Nanomaterials for Near Infrared Fluorescence and Magnetic Resonance Dual-mode Imaging
- 发光学报 2022年43卷第3期页码：350-358
- 作者机构：
  
  河北大学　物理科学与技术学院，河北　保定　071002
- 作者简介：
  
  何旭(1995-)，男，河北廊坊人，硕士研究生，2019年于河北大学获得学士学位，主要从事稀土掺杂发光材料的研究。E-mail: 18830285787@163.com
  李旭(1978-)，男，河北石家庄人，博士，研究员，2016年于北京交通大学获得博士学位，主要从事稀土发光材料方面的研究。E-mail: lixcn@sina.com
  王凤和(1983-)，女，河北沧州人，博士，讲师，2017年于新加坡国立大学获得博士学位，主要从事稀土发光材料方面的研究。E-mail: fenghe_wang@hotmail.com
- 基金信息：
  
  河北省自然科学基金(F2019201316);国家自然科学基金(51802069);中央引导地方项目(216Z104G);河北大学人才引进项目(521000981236);河北大学研究生创新项目(HUB2021ss066)
- DOI：10.37188/CJL.20210391
  中图分类号： O482.31
- 收稿：2021-12-13，
  
  修回：2021-12-29，
  
  纸质出版：2022-03
- 稿件说明：
移动端阅览
何旭, 吴亚楠, 蒋越宁, 等. 适用于近红外荧光/核磁双模成像的GdF₃∶Nd³⁺,Yb³⁺@NaGdF₄纳米材料[J]. 发光学报, 2022,43(3):350-358. DOI: 10.37188/CJL.20210391.

Xu HE, Ya-nan WU, Yue-ning JIANG, et al. GdF₃∶Nd³⁺,Yb³⁺@NaGdF₄ Nanomaterials for Near Infrared Fluorescence and Magnetic Resonance Dual-mode Imaging[J]. Chinese Journal of Luminescence, 2022, 43(3): 350-358. DOI: 10.37188/CJL.20210391.
何旭, 吴亚楠, 蒋越宁, 等. 适用于近红外荧光/核磁双模成像的GdF₃∶Nd³⁺,Yb³⁺@NaGdF₄纳米材料[J]. 发光学报, 2022,43(3):350-358. DOI: 10.37188/CJL.20210391. DOI：

Xu HE, Ya-nan WU, Yue-ning JIANG, et al. GdF₃∶Nd³⁺,Yb³⁺@NaGdF₄ Nanomaterials for Near Infrared Fluorescence and Magnetic Resonance Dual-mode Imaging[J]. Chinese Journal of Luminescence, 2022, 43(3): 350-358. DOI: 10.37188/CJL.20210391. DOI：

摘要

利用Nd

与Yb

之间的能量传递，设计了808 nm激发下具有近红外光致发光的GdF

∶Nd

@NaGdF

磁性纳米探针。通过合成参数调控，研究了反应时间和前驱物浓度对GdF

∶Nd

材料形貌的影响。GdF

∶Nd

在808 nm激发下在近红外(NIR)第一/第二窗口具有较宽的发射峰(970~1 070 nm)，共掺杂体系实现了Yb

和Nd

双发光中心发光，有效提高了近红外区间的

发光性能，同时克服了用980 nm激发的荧光成像引起生物组织过热的缺点。表面包覆NaGdF

惰性壳可以进一步提高GdF

∶Nd

的近红外发光强度，研究了不同厚度NaGdF

惰性壳对GdF

∶Nd

发光增强的影响。由于Gd

具有的顺磁特性，GdF

∶Nd

@NaGdF

显示出顺磁性能，磁化值为0.45 A·m

/kg，适合作为磁共振成像(MRI)T1探针。GdF

∶Nd

@NaGdF

纳米颗粒在NIR荧光成像和MRI领域具有广阔的应用前景。

Abstract

GdF

∶Nd

magnetic nanocomposites with near-infrared photoluminescence under 808 nm excitation were designed based on the energy transfer between Nd

and Yb

. The influence of synthesis parameters on the morphology of GdF

∶Nd

was discussed. The obtained GdF

∶Nd

exhibits a wide emission band(970-1 070 nm) under 808 nm excitation. The co-doping system of Nd

and Yb

can realize the dual emission center of Yb

and Nd

as the emission center. It effectively improves the luminescence performance in the near-infrared region and overcomes the disadvantage of overheating biological tissues by fluorescence imaging under 980 nm excitation. An inert shell of NaGdF

was grown on GdF

∶Nd

surface

which could improve the emission intensity dramatically. Meanwhile

the effect of NaGdF

inter shell with different thicknesses on the luminescence enhancement of GdF

∶Nd

was studied. The final products GdF

∶Nd

@NaGdF

are paramagnetic with magnetization 0.45 A·m

/kg. This indicates that GdF

∶Nd

@NaGdF

has broad application prospects in both the fluorescence imaging field and magnetic resonance imaging(MRI) field.

关键词

Keywords

references

ZHANG H X , CHEN Z H , LIU X , et al . A mini-review on recent progress of new sensitizers for luminescence of lanthanide doped nanomaterials [J ] . Nano Res. , 2020 , 13 ( 7 ): 1795 - 1809 .

CHEN S , WEITEMIER A Z , ZENG X , et al . Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics [J ] . Science , 2018 , 359 ( 6376 ): 679 - 684 .

PĄZIK R , ZACHANOWICZ E , PO ŻNIAK B , et al . Non-contact Mn 1- x Ni x Fe 2 O 4 ferrite nano-heaters for biolo gical applications—heat energy generated by NIR irradiation [J ] . RSC Adv. , 2017 , 7 ( 29 ): 18162 - 18171 .

LI C Y , WANG Q B . Advanced NIR-Ⅱ fluorescence imaging technology for in vivo precision tumor theranostics [J ] . Adv. Therap. , 2019 , 2 ( 9 ): 1900053 .

FAN Y , LIU L , ZHANG F . Exploiting lanthanide-doped upconversion nanoparticles with core/shell structures [J ] . Nano Today , 2019 , 25 : 68 - 84 .

PROFIO A E , BALCHUM O J , LAM S . Endoscopic fluorescence detection of early lung cancer [C ] . Proceedings of SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis : Mechanisms and Techniques , Los Angeles , 1991 : 1426 .

HUANG J G , XIE C , ZHANG X D , et al . Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction [J ] . Angew. Chem. Int. Ed. , 2019 , 58 ( 42 ): 15120 - 15127 .

HAO X X , LI C Y , ZHANG Y J , et al . Programmable chemotherapy and immunotherapy against breast cancer guided by multiplexed fluorescence imaging in the second near-infrared window [J ] . Adv. Mater. , 2018 , 30 ( 51 ): 1804437-1-8 .

DEL ROSAL B , VILLA I , JAQUE D , et al . In vivo autofluorescence in the biological windows:the role of pigmentation [J ] . J. Biophotonics , 2016 , 9 ( 10 ): 1059 - 1067 .

WEN Q X , ZHANG Y J , LI C Y , et al . NIR-Ⅱ fluorescent self-assembled peptide nanochain for ultrasensitive detection of peritoneal metastasis [J ] . Angew. Chem. Int. Ed. , 2019 , 58 ( 32 ): 11001 - 11006 .

BASHKATOV A N , GENINA E A , KOCHUBEY V I , et al . Optical properties of human skin,subcutaneous and mucous tissues in the wavelength range from 400 to 2 000 nm [J ] . J. Phys. D: Appl. Phys. , 2005 , 38 ( 15 ): 2543 - 2555 .

LI C Y , CHEN G C , ZHANG Y J , et al . Advanced fluorescence imaging technology in the near-infrared-Ⅱ window for biomedical applications [J ] . J. Am. Chem. Soc. , 2020 , 142 ( 35 ): 14789 - 14804 .

HU Z H , FANG C , LI B , et al . First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-Ⅰ/Ⅱ windows [J ] . Nat. Biomed. Eng. , 2020 , 4 ( 3 ): 259 - 271 .

HU Z H , CHEN W H , TIAN J , et al . NIRF nanoprobes for cancer molecular imaging:approaching clinic [J ] . Trends. Mol. Med. , 2020 , 26 ( 5 ): 469 - 482 .

FAN Y , WANG P Y , LU Y Q , et al . Lifetime-engineered NIR-Ⅱ nanoparticles unlock multiplexed in vivo imaging [J ] . Nat. Nanotechnol. , 2018 , 13 ( 10 ): 941 - 946 .

DONG H , DU S R , ZHENG X Y , et al . Lanthanide nanoparticles:from design toward bioimaging and therapy [J ] . Chem. Rev. , 2015 , 115 ( 19 ): 10725 - 10815 .

BRENIER A . Excited-state dynamics including radiative diffusion in quasi-three-level laser crystals:application to Yb 3+ -doped Y 3 Al 5 O 12 [J ] . J. Opt. Soc. Amer. B , 2006 , 23 ( 10 ): 2209 - 2216 .

LI X L , JIANG M Y , LI Y B , et al . 808 nm laser-triggered NIR-Ⅱ emissive rare-earth nanoprobes for small tumor detection and blood vessel imaging [J ] . Mater. Sci. Eng. C , 2019 , 100 : 260 - 268 .

WANG F H , BAE K , HUANG Z W , et al . Two-photon graphene quantum dot modified Gd 2 O 3 nanocomposites as a dual-mode MRI contrast agent and cell labelling agent [J ] . Nanoscale , 2018 , 10 ( 12 ): 5642 - 5649 .

ROBERTS J E . Lanthanum and neodymium salts of trifluoroacetic acid [J ] . J. Am. Chem. Soc. , 1961 , 83 ( 5 ): 1087 - 1088 .

MAI H X , ZHANG Y W , SI R , et al . High-quality sodium rare-earth fluoride nanocrystals:controlled synthesis and optical properties [J ] . J. Am. Chem. Soc. , 2006 , 128 ( 19 ): 6426 - 6436 .

CHATTERJEE D K , RUFAIHAH A J , ZHANG Y . Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals [J ] . Biomaterials , 2008 , 29 ( 7 ): 937 - 943 .

LI X K , YOU F T , PENG H S , et al . Synthesis and near-infrared luminescent properties of NaGdF 4 ∶Nd 3+ @NaGdF 4 core/shell nanocrystals with different shell thickness [J ] . J. Nanosci. Nanotechnol. , 2016 , 16 ( 4 ): 3940 - 3944 .

WANG F H , PENG E , LIU F , et al . Fluorescence-tagged amphiphilic brush copolymer encapsulated Gd 2 O 3 core-shell nanostructures for enhanced T 1 contrast effect and fluorescent imaging [J ] . Nanotechnology , 2016 , 27 ( 42 ): 425101-1-12 .

WANG Y F , LIU G Y , SUN L D , et al . Nd 3+ -sensitized upconversion nanophosphors:efficient in vivo bioimaging probes with minimized heating effect [J ] . ACS Nano , 2013 , 7 ( 8 ): 7200 - 7206 .

TAN M L , DEL ROSAL B , ZHANG Y Q , et al . Rare-earth-doped fluoride nanoparticles with engineered long luminescence lifetime for time-gated in vivo optical imaging in the second biological window [J ] . Nanoscale , 2018 , 10 ( 37 ): 17771 - 17780 .

林少伟 , 赵婧 , 法信蒙 , 等 . 808 nm激发的NaYF 4 ∶Yb/Tm/Ca@NaGdF 4 ∶Nd/Yb上转换纳米粒子的制备及其发光性质 [J ] . 发光学报 , 2020 , 41 ( 11 ): 1358 - 1366 .

LIN S W , ZHAO J , FA X M , et al . Preparation and luminescent properties of NaYF 4 ∶Yb/Tm/Ca@NaGdF 4 ∶Nd/Yb up-conversion nanoparticles excited at 808 nm [J ] . Chin. J. Lumin. , 2020 , 41 ( 11 ): 1358 - 1366 . (in Chinese)

DAI Y , YANG D P , YU D P , et al . Mussel-inspired polydopamine-coated lanthanide nanoparticles for NIR-Ⅱ/CT dual imaging and photothermal therapy [J ] . ACS Appl. Mater. Interfaces , 2017 , 9 ( 32 ): 26674 - 26683 .

SUN Z Q , HUANG H Y , ZHANG R , et al . Activatable rare earth near-infrared-Ⅱ fluorescence ratiometric nanoprobes [J ] . Nano Lett. , 2021 , 21 ( 15 ): 6576 - 6583 .

BEDNARKIEWICZ A , WAWRZYNCZYK D , NYK M , et al . Synthesis and spectral properties of colloidal Nd 3+ doped NaYF 4 nanocrystals [J ] . Opt. Mater. , 2011 , 33 ( 10 ): 1481 - 1486 .

CHEN G Y , OHULCHANSKYY T Y , LIU S , et al . Core/shell NaGdF 4 ∶Nd 3+ /NaGdF 4 nanocrystals with efficient near-infrared to near-infrared downconversion photoluminescence for bioimaging applications [J ] . ACS Nano , 2012 , 6 ( 4 ): 2969 - 2977 .

HAN Q , SUN J C , WU H Y , et al . Enhanced up-conversion luminescence efficiency of heterogeneous hetero-phase α-NaLuF 4 ∶Yb/Er@β-NaYF 4 ∶Yb core-shell structure nanocrystals [J ] . J. Alloys Compd. , 2020 , 848 : 156543 .

浏览量

473

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

Ce3+⁃Cr3+共掺杂Ba3Sc4O9荧光材料的发光性能

纳米单斜相Gd2O3：Bi3+,Nd3+的燃烧法制备和近红外发光

Tb3+→Sm3+能量传递调控的多色应力发光材料及其动态防伪应用

CaYAl3O7∶Eu2+，Eu3+，Tb3+的多模式应力发光性能及颜色调控

可见光波段激光器线宽压缩技术研究进展