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1.浙江大学材料科学与工程学院 硅材料国家重点实验室,浙江 杭州 310027
2.杭州安旭生物科技有限公司,浙江 杭州 310011
[ "夏天昊(1998-),男,湖北武汉人,硕士研究生,2021年于武汉理工大学获得学士学位,主要从事微纳米发光材料的研究。E-mail: 22126110@zju.edu.cn" ]
[ "乔旭升(1980-),男,河南洛阳人,博士,副教授,博士生导师,2007年于浙江大学获得博士学位,主要从事发光玻璃陶瓷、荧光粉与分子动力学模拟方面的教学与研究。E-mail: qiaoxus@zju.edu.cn" ]
纸质出版日期:2022-03,
收稿日期:2021-12-09,
修回日期:2021-12-27,
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夏天昊, 王云鹏, 戴晓茹, 等. 金纳米簇化学发光体外生物检测应用研究进展[J]. 发光学报, 2022,43(3):314-326.
Tian-hao XIA, Yun-peng WANG, Xiao-ru DAI, et al. Research Progresses on Chemiluminescent Gold Nanoclusters Applied in Biological
夏天昊, 王云鹏, 戴晓茹, 等. 金纳米簇化学发光体外生物检测应用研究进展[J]. 发光学报, 2022,43(3):314-326. DOI: 10.37188/CJL.20210385.
Tian-hao XIA, Yun-peng WANG, Xiao-ru DAI, et al. Research Progresses on Chemiluminescent Gold Nanoclusters Applied in Biological
金纳米簇是一种制备工艺简单、具有分子级尺寸和量子效应的新型发光材料,近年来在化学发光检测中得到了广泛应用,特别是较多应用于体外生物检测。本文综述了金纳米簇化学发光(含电化学发光)体系在体外生物检测中的应用进展。首先,阐释了金纳米簇的合成方法、结构、性质及其化学发光基本原理;其次,总结了国内外近年来基于该体系的体外生物检测研究进展,并梳理了改善发光强度和检测灵敏度的已有策略;最后,对金纳米簇化学发光的未来发展趋势进行了展望。
Gold nanoclusters are novel luminescent materials with simple preparation method
molecular size and quantum effect
which have been widely applied in chemiluminescence detection in recent years
especially in
in vitro
biological detection. This article reviews the progress of gold nanoclusters chemiluminescence(including electrochemiluminescence) system in the application of
in vitro
biological detection. First
the synthesis
structure
properties of gold nanoclusters and the basic principle of chemiluminescence system are introduced and explained theoretically. Next
recent reports are summarized on
in vitro
biological detection with gold nanoclusters
and strategies in literatures are overviewed and commented on how to improve the luminescent intensity and detection sensitivity. Finally
we give an outlook on the development trend of gold nanoclusters chemiluminescence system.
金纳米簇化学发光电化学发光体外生物检测
gold nanoclusterschemiluminescenceelectrochemiluminescencein vitro biological detection
刘茹, 王亚玲, 崔岩岩, 等. 贵金属团簇探针用于细胞成像及体外检测 [J]. 生物化学与生物物理进展, 2013, 40(10):977-989.
LIU R, WANG Y L, CUI Y Y, et al. Recent development of noble metal clusters for bioimaging and in vitro detection [J]. Prog. Biochem. Biophys., 2013, 40(10):977-989. (in Chinese)
王孟珂, 苏星光. 基于金属纳米簇的荧光传感平台的最新研究进展 [J]. 分析测试学报, 2021, 40(6):805-815.
WANG M K, SU X G. Recent advances in metal nanoclusters-based fluorescent platforms for biosensing [J]. J. Instrum. Anal., 2021, 40(6):805-815. (in Chinese)
林金明. 化学发光基础理论与应用 [M]. 北京: 化学工业出版社, 2004.
LIN J M. Chemiluminescence-basic Principles and Applications [M]. Beijing: Chemical Industry Press, 2004. (in Chinese)
姜晖, 王雪梅. 基于金属纳米簇的电化学发光分析应用研究进展 [J]. 分析化学, 2017, 45(12):1776-1785.
JIANG H, WANG X M. Progress of metal nanoclusters-based electrochemiluminescent analysis [J]. Chin. J. Anal. Chem., 2017, 45(12):1776-1785. (in Chinese)
LIANG Y, ZHANG T, TANG M. Toxicity of quantum dots on target organs and immune system [J]. J. Appl. Toxicol., 2021, 42(1):17-40.
CUI M L, ZHAO Y, SONG Q J. Synthesis,optical properties and applications of ultra-small luminescent gold nanoclusters [J]. TrAC Trends Anal. Chem., 2014, 57:73-82.
LIN C A J, LEE C H, HSIEH J T, et al. Synthesis of fluorescent metallic nanoclusters toward biomedical application:recent progress and present challenges [J]. J. Med. Biol. Eng., 2009, 29(6):276-283.
ZHANG L B, WANG E K. Metal nanoclusters:new fluorescent probes for sensors and bioimaging [J]. Nano Today, 2014, 9(1):132-157.
TAO Y, LI M Q, REN J S, et al. Metal nanoclusters:novel probes for diagnostic and therapeutic applications [J]. Chem. Soc. Rev., 2015, 44(23):8636-8663.
HAN S, ZHAO Y H, ZHANG Z C, et al. Recent advances in electrochemiluminescence and chemiluminescence of metal nanoclusters [J]. Molecules, 2020, 25(21):5208-1-23.
JIANG H, LIU L, WANG X M. Red-emitted electrochemiluminescence by yellow fluorescent thioglycol/glutathione dual thiolate co-coated Au nanoclusters [J]. Nanoscale, 2017, 9(28):9792-9796.
LI Q R, ZHOU R Z, SUN Y, et al. Synthesis and antitumor application of antiangiogenetic gold nanoclusters [J]. ACS Appl. Mater. Interfaces, 2021, 13(10):11708-11720.
MARTÍN-BARREIRO A, DE MARCOS S, GALBÁN J. Gold nanoclusters as a quenchable fluorescent probe for sensing oxygen at high temperatures [J]. Microchim. Acta, 2018, 185(3):171-1-7.
DUAN Y, DUAN R P, LIU R, et al. Chitosan-stabilized self-assembled fluorescent gold nanoclustersfor cell imaging and biodistribution in vivo [J]. ACS Biomater. Sci. Eng., 2018, 4(3):1055-1063.
DENG H H, WU G W, ZOU Z Q, et al. pH-sensitive gold nanoclusters:preparation and analytical applications for urea,urease,and ureaseinhibitor detection [J]. Chem. Commun., 2015, 51(37):7847-7850.
SANG FM, ZHANG X, SHEN F Y. Fluorescent methionine-capped gold nanoclusters for ultra-sensitive determination of copper(Ⅱ) and cobalt(Ⅱ),and their use in a test strip [J]. Microchim. Acta, 2019, 186(6):373-1-9.
XIE J P, ZHENG Y G, YING J Y. Protein-directed synthesis of highly fluorescent gold nanoclusters [J]. J. Am. Chem. Soc., 2009, 131(3):888-889.
YANG L N, LOU X F, YU F F, et al. Cross-linking structure-induced strong blueemissive gold nanoclusters for intracellularsensing [J]. Analyst, 2019, 144(8):2765-2772.
HUANG Y X, YUE N N, LI Y, et al. One-step synthesis of cationic gold nanoclusters with highcatalytic activity on luminol chemiluminescence reaction [J]. Luminescence, 2021, 36(1):85-93.
LEI Z, LI J J, WAN X K, et al. Isolation and total structure determination of an all-alkynyl-protected gold nanocluster Au144 [J]. Angew. Chem. Int. Ed., 2018, 57(28):8639-8643.
ZHUANG S L, LIAO L W, LI M B, et al. The fcc structure isomerization in goldnanoclusters [J]. Nanoscale, 2017, 9(39):14809-14813.
ZHANG B H, CHEN J S, CAO Y T, et al. Ligand design in ligand-protected gold nanoclusters [J]. Small, 2021, 17(27):2004381.
YUAN X, GOSWAMI N, MATHEWS I, et al. Enhancing stability through ligand-shell engineering:acase study with Au25(SR)18 nanoclusters [J]. Nano Res., 2015, 8(11):3488-3495.
JIANG X F, WANG X Y, YAO C, et al. Surface-engineered gold nanoclusters with biological assembly-amplified emission for multimode imaging [J]. J. Phys. Chem. Lett., 2019, 10(17):5237-5243.
康振辉, 刘阳, 毛宝东. 量子点的合成与应用 [M]. 北京: 科学出版社, 2018.
KANG Z H, LIU Y, MAO B D. Guantum Dots: Synthesis and Applications [M]. Beijing: Science Press, 2018. (in Chinese)
KUMAR B, KAWAWAKI T, SHIMIZU N, et al. Gold nanoclusters as electrocatalysts:size,ligands,heteroatom doping,and charge dependences [J]. Nanoscale, 2020, 12(18):9969-9979.
ZHENG K Y, XIE J P. Cluster materials as traceable antibacterial agents [J]. Acc. Mater. Res., 2021, 2(11):1104-1116.
XIE S H, TSUNOYAMA H, KURASHIGE W, et al. Enhancement in aerobic alcohol oxidation catalysis of Au25clusters by single Pd atom doping [J]. ACS Catal., 2012, 2(7):1519-1523.
SRINIVASULU Y G, GOSWAMI N, YAO Q F, et al. High-yield synthesis of AIE-type Au22(SG)18nanoclusters through precursor engineering and its pH-dependent size transformation [J]. J. Phys. Chem. C, 2021, 125(7):4066-4076.
PENG H P, HUANG Z N, SHENG Y L, et al. Pre-oxidation of gold nanoclusters results in a 66% anodic electrochemiluminescence yield and drives mechanistic insights [J]. Angew. Chem. Int. Ed., 2019, 58(34):11691-11694.
安晓刚, 杜捷, 卢小泉. 基于贵金属纳米簇的电化学发光传感器在生命分析中的应用 [J]. 发光学报, 2017, 38(5):675-684.
AN X G, DU J, LU X Q. Application in life analysis of electrochemiluminescent sensor based on noble metal nanocluster [J]. Chin. J. Lumin., 2017, 38(5):675-684. (in Chinese)
林金明, 赵利霞, 王栩. 化学发光免疫分析 [M]. 北京: 化学工业出版社, 2008.
LIN J M, ZHAO L X, WANG X. Chemiluminescence Immunoassay [M]. Beijing: Chemical Industry Press, 2008. (in Chinese)
FANG Y M, SONG J, LI J, et al. Electrogenerated chemiluminescence from Au nanoclusters [J]. Chem. Commun., 2011, 47(8):2369-2371.
HESARI M, DING Z F. Efficient near-infrared electrochemiluminescence from Au18 nanoclusters [J]. Chem. -Eur. J., 2021, 27(60):14821-14825.
WANG T Y, WANG D C, PADELFORD J W, et al. Near-infrared electrogenerated chemiluminescence from aqueous soluble lipoic acid Au nanoclusters [J]. J. Am. Chem. Soc., 2016, 138(20):6380-6383.
LI L L, LIU H Y, SHEN Y Y, et al. Electrogenerated chemiluminescence of Au nanoclusters for the detection of dopamine [J]. Anal. Chem., 2011, 83(3):661-665.
PENG H P, JIAN M L, DENG H H, et al. Valence states effect on electrogenerated chemiluminescence of gold nanocluster [J]. ACS Appl. Mater. Interfaces, 2017, 9(17):14929-14934.
HESARI M, DING Z F. A grand avenue to Au nanocluster electrochemiluminescence [J]. Acc. Chem. Res., 2017, 50(2):218-230.
肖勤, 林金明. 化学发光免疫分析新技术研究进展 [J]. 分析试验室, 2017, 36(7):861-868.
XIAO Q, LIN J M. New technology progress on chemiluminescence immunoassay [J]. Chin. J. Anal. Lab., 2017, 36(7):861-868. (in Chinese)
ZHANG K X, SUN M X, SONG H J, et al. Synergistic chemiluminescence nanoprobe:Au clusters-Cu2+-induced chemiexcitation of cyclic peroxides and resonance energy transfer [J]. Chem. Commun., 2020, 56(21):3151-3154.
ZHU L P, YE J, YAN M X, et al. A wavelength-resolved electrochemiluminescence resonance energy transfer ratiometric immunosensor for detection of cardiac troponin Ⅰ [J]. Analyst, 2019, 144(22):6554-6560.
CHENG Y, LEI J P, CHEN Y L, et al. Highly selective detection of microRNA based on distance-dependent electrochemi-luminescence resonance energy transfer between CdTe nanocrystals and Au nanoclusters [J]. Biosens. Bioelectron., 2014, 51:431-436.
庞彬彬, 孙海鹰, 徐云根. 化学发光试剂的研究新进展 [J]. 化学试剂, 2017, 39(9):942-948.
PANGB B, SUN H Y, XU Y G. New progress of chemiluminescence reagents [J]. Chem. Reagents, 2017, 39(9):942-948. (in Chinese)
ZHANG Z F, CUI H, LAI C Z, et al. Gold nanoparticle-catalyzed luminol chemiluminescence and its analytical applications [J]. Anal. Chem., 2005, 77(10):3324-3329.
DENG M, XU S J, CHEN F N. Enhanced chemiluminescence of the luminol-hydrogen peroxide system by BSA-stabilized Au nanoclusters as a peroxidase mimic and its application [J]. Anal. Methods, 2014, 6(9):3117-3123.
HE Y Y, SUI Y Y, XU S J, et al. Au NCs-enhanced chemiluminescence from NaHSO3-H2O2 and its analytical application [J]. RSC Adv., 2016, 6(6):4657-4662.
YANG D Q, HE Y Y, CHEN F N. Determination of fluvoxamine maleate in human urine and human serum using alkaline KMnO4-rhodamine B chemiluminescence [J]. Luminescence, 2017, 32(6):1077-1083.
LIU B, TANG B Z. Aggregation-induced emission:more is different [J]. Angew. Chem. Int. Ed., 2020, 59(25):9788-9789.
ZHANG L J, HE N, LU C. Aggregation-induced emission:asimple strategy to improve chemiluminescence resonance energy transfer [J]. Anal. Chem., 2015, 87(2):1351-1357.
JIANG H, QIN Z J, ZHENG Y K, et al. Aggregation-induced electrochemiluminescence by metal-binding protein responsive hydrogel scaffolds [J]. Small, 2019, 15(18):1901170-1-8.
YU L, ZHANG Q, KANG Q, et al. Near-infrared electrochemiluminescence immunoassay with biocompatible Au nanoclusters as tags [J]. Anal. Chem., 2020, 92(11):7581-7587.
JIA Y, LIU S H, DU Y, et al. Intramolecular coreaction accelerated electrochemiluminescence of polypeptide-biomineralized gold nanoclusters for targeted detection of biomarkers [J]. Anal. Chem., 2020, 92(13):9179-9187.
YOU X Y, LI Y H, LI B P, et al. Gold nanoclusters-based chemiluminescence resonance energy transfer method for sensitive and label-free detection of trypsin [J]. Talanta, 2016, 147:63-68.
ZHOU Y, CHAI Y Q, YUAN R. Highly efficient dual-polar electrochemiluminescence from Au25 nanoclusters:the next generation of multibiomarker detection in a single step [J]. Anal. Chem., 2019, 91(22):14618-14623.
YANG F, ZHONG X, JIANG X Y, et al. An ultrasensitive aptasensor based on self-enhanced Au nanoclusters as highly efficient electrochemiluminescence indicator and multi-site landing DNA walker as signal amplification [J]. Biosens. Bioelectron., 2019, 130:262-268.
ZHOU Y, CHEN S H, LUO X L, et al. Ternary electrochemiluminescence nanostructure of Au nanoclusters as a highly efficient signal label for ultrasensitive detection of cancer biomarkers [J]. Anal. Chem., 2018, 90(16):10024-10030.
JIA Y, YANG L, XUE J W, et al. Bioactivity-protected electrochemiluminescence biosensor using gold nanoclusters as the low-potential luminophor and Cu2S snowflake as co-reaction accelerator for procalcitonin analysis [J]. ACS Sens., 2019, 4(7):1909-1916.
ZHU L P, YE J, YAN M X, et al. Electrochemiluminescence immunosensor based on Au nanocluster and hybridization chain reaction signal amplification for ultrasensitive detection of cardiac troponin I [J]. ACS Sens., 2019, 4(10):2778-2785.
WU Z L, LIU S H, LI Y Y, et al. Electrochemiluminescence resonance energy transfer system fabricated by quantum state complexes for cardiac troponin I detection [J]. Sens. Actuators B, 2021, 336:129733-1-8.
HONG G L, SU C P, HUANG Z N, et al. Electrochemiluminescence immunoassay platform withimmunoglobulin G-encapsulated gold nanoclusters as a “two-in-one” probe [J]. Anal. Chem., 2021, 93(38):13022-13028.
HUO X L, ZHANG N, YANG H, et al. Electrochemiluminescence resonance energy transfer system for dual-wavelength ratiometric miRNA detection [J]. Anal. Chem., 2018, 90(22):13723-13728.
LIU P F, ZHAO K R, LIU Z J, et al. Cas12a-based electrochemiluminescence biosensor for target amplification-free DNA detection [J]. Biosens. Bioelectron., 2021, 176:112954-1-7.
孔亚访, 樊爱萍. 金纳米簇增强的化学发光反应及在葡萄糖检测中的应用 [J]. 分析科学学报, 2018, 34(1):47-51.
KONG Y F, FAN A P. Gold nanoclusterenhanced chemiluminescence reaction and its application in glucose detection [J]. J. Anal. Sci., 2018, 34(1):47-51. (in Chinese)
LI Y H, PENG W C, YOUX Y. Determination of dopamine by exploiting the catalytic effect of hemoglobin-stabilized gold nanoclusters on the luminol-NaIO4 chemiluminescence system [J]. Microchim. Acta, 2017, 184(9):3539-3545.
YANG D Q, HE Y Y, SUI Y Y, et al. Gold nanoclusters-catalyzed rhodamine 6G-K3Fe(CN)6 chemiluminescence and its application [J]. Anal. Methods, 2016, 8(39):7272-7278.
HUANGM Y, WANG Y Z, SONG M L, et al. Bovine serum albumin-encapsulated gold nanoclusters-Cu2+ synergize and promote calcein chemiluminescence for glutathione detection in human whole blood [J]. Microchem. J., 2021, 170:106749.
HALAWA M I, XIA Q, LI B S. An ultrasensitive chemiluminescent biosensor for tracing glutathione in human serum using BSA@AuNCs as a peroxidase-mimetic nanozyme on a luminol/artesunate system [J]. J. Mater. Chem. B, 2021, 9(38):8038-8047.
YOUSEFZADEH A, ABOLHASANI J, HASSANZADEH J, et al. Ultrasensitive chemiluminescence assay for cimetidine detection based on the synergistic improving effect of Au nanoclusters and graphene quantum dots [J]. Luminescence, 2019, 34(2):261-271.
ZHANG C, FAN Y, ZHANG H, et al. An ultrasensitive signal-on electrochemiluminescence biosensor based on Au nanoclusters for detecting acetylthiocholine [J]. Anal. Bioanal. Chem., 2019, 411(4):905-913.
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