pH响应型碳点的荧光机制和生物医学应用

何松杰; 张清梅; 张路鹏; 杜秀娟; 陈峰华; 李冰

doi:10.37188/CJL.20210307

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pH响应型碳点的荧光机制和生物医学应用

发光学应用及交叉前沿 | 更新时间：2022-01-14

- pH响应型碳点的荧光机制和生物医学应用
  增强出版
- Fluorescence Mechanism and Biomedical Applications of pH-responsive Carbon Dots
- 发光学报 2022年43卷第1期页码：137-151
- 作者机构：
  
  1.太原科技大学　应用科学学院，山西　太原　030024
  2.福建师范大学物理与能源学院　福建省量子调控与新能源材料重点实验室，福建　福州　350117
  3.山西医科大学　口腔医学院，山西　太原　030051
- 作者简介：
  
  [ "何松杰(1998-)，男，河南周口人，硕士研究生，2020年于南通大学获得学士学位，主要从事碳点材料的制备及其在生物医学和农业方面应用的研究。E-mail: hsjxmm@foxmail.com" ]
  [ "张清梅(1985-)，女，山西临县人，博士，副教授，2014年于南京大学获得博士学位，主要从事碳点材料的制备及其在离子检测及生物医学方面应用的研究。E-mail: qmzhang@tyust.edu.cn" ]
  [ "李冰(1975-)，男，山西运城人，博士，教授，主任医师，博士生导师，2014年于解放军总医院和山西医科大学获得博士学位，主要从事新型碳纳米口腔材料的研发及口腔图像识别处理的研究。E-mail: libing-1975@163.com" ]
- 基金信息：
  
  国家自然科学基金(11704274);福建省量子调控与新能源材料重点实验室开放课题(QMNEM1801);山西省自然科学基金(201901D111267);山西省领军人才项目(20190042)
- DOI：10.37188/CJL.20210307
  中图分类号： O482.31
- 纸质出版日期：2022-01，
  
  收稿日期：2021-09-24，
  
  修回日期：2021-10-12，
扫描看全文
何松杰, 张清梅, 张路鹏, 等. pH响应型碳点的荧光机制和生物医学应用[J]. 发光学报, 2022,43(1):137-151.

Song-jie HE, Qing-mei ZHANG, Lu-peng ZHANG, et al. Fluorescence Mechanism and Biomedical Applications of pH-responsive Carbon Dots[J]. Chinese Journal of Luminescence, 2022,43(1):137-151.
何松杰, 张清梅, 张路鹏, 等. pH响应型碳点的荧光机制和生物医学应用[J]. 发光学报, 2022,43(1):137-151. DOI： 10.37188/CJL.20210307.

Song-jie HE, Qing-mei ZHANG, Lu-peng ZHANG, et al. Fluorescence Mechanism and Biomedical Applications of pH-responsive Carbon Dots[J]. Chinese Journal of Luminescence, 2022,43(1):137-151. DOI： 10.37188/CJL.20210307.

摘要

碳点(CDs)作为一种新型的零维碳基纳米材料，由于其优异的荧光性质、良好的生物兼容性、低细胞毒性以及丰富的表面官能团等性质，在荧光传感和生物医学领域具有巨大的应用潜力。特别是针对肿瘤弱酸性的微环境特点，设计pH响应型碳点来实现对肿瘤的特异性治疗将尤为重要。本文对近年来基于pH响应型碳点的研究工作进行了系统的调研，综述了pH响应型碳点的荧光机制及其在pH传感、生物成像及癌症治疗等生物医学领域的应用，并对pH响应型碳点目前面临的主要挑战以及未来发展的方向进行了展望。

Abstract

As a new type of zero-dimensional carbon-based nanomaterials

carbon dots(CDs) have a great application potential in the fields of fluorescence sensing and biomedicine due to their excellent fluorescence properties

good biocompatibility

low cytotoxicity

and large surface functional groups. Especially given the weakly acidic microenvironment characteristics of tumors

it is crucial to design pH-responsive carbon dots to achieve specific treatment. This article has conducted a systematic investigation on the research work based on pH-responsive carbon dots in recent years and reviewed the fluorescence mechanism of pH-responsive carbon dots and their applications in biomedical fields such as pH sensing

bioimaging

and cancer treatment. Finally

the main challenges currently faced by pH-responsive carbon dots and the future development direction have been prospected.

关键词

pH响应型碳点荧光机制pH传感生物成像癌症治疗

Keywords

pH-responsive carbon dotsfluorescence mechanismpH sensingbioimagingcancer treatment

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