红光/近红外光响应碳点在肿瘤治疗中的应用进展
增强出版Recent Advances of Red/Near Infrared Light Responsive Carbon Dots for Tumor Therapy
- 发光学报 2021年42卷第8期 页码：1155-1171
- 作者机构：
1.中国科学院理化技术研究所 光化学转换与功能材料重点实验室，北京 100190
2.中国科学院大学 未来技术学院，北京 100049
- 作者简介：
[ "南福春(1992-)，男，山东潍坊人，博士研究生，2017年于青岛科技大学获得硕士学位，主要从事新型碳纳米材料在肿瘤诊疗中的研究。E-mail: nanfuchun@mail.ipc.ac.cn" ]
[ "葛介超(1970-)，男，山东临沂人，博士，研究员，2008年于山东师范大学获得博士学位，主要从事新型纳米材料在光诊疗及光催化中应用的研究。E-mail: jchge2010@mail.ipc.ac.cn" ]
- 基金信息：国家自然科学基金(51972315)
DOI：10.37188/CJL.20210163
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南福春, 薛小矿, 葛介超, 等. 红光/近红外光响应碳点在肿瘤治疗中的应用进展[J]. 发光学报, 2021,42(8):1155-1171.
Fu-chun NAN, Xiao-kuang XUE, Jie-chao GE, et al. Recent Advances of Red/Near Infrared Light Responsive Carbon Dots for Tumor Therapy[J]. Chinese Journal of Luminescence, 2021,42(8):1155-1171.
南福春, 薛小矿, 葛介超, 等. 红光/近红外光响应碳点在肿瘤治疗中的应用进展[J]. 发光学报, 2021,42(8):1155-1171. DOI： 10.37188/CJL.20210163.
Fu-chun NAN, Xiao-kuang XUE, Jie-chao GE, et al. Recent Advances of Red/Near Infrared Light Responsive Carbon Dots for Tumor Therapy[J]. Chinese Journal of Luminescence, 2021,42(8):1155-1171. DOI： 10.37188/CJL.20210163.
摘要
碳点作为一种新型碳纳米材料，具有优异的光学特性、良好的生物相容性以及催化活性，在生物医学、能源、环境等领域展现出巨大的应用潜力。红光/近红外光响应碳点具有组织穿透深度大、生物体自发光干扰较小、对组织损伤小等优点，在生物医学研究领域倍受关注。本文首先介绍了影响碳点吸收/发光的因素，随后评述了近几年红光/近红外光响应碳点在肿瘤治疗中的新进展，主要包括光动力治疗、光热治疗、光动力/光热协同治疗等。同时，针对肿瘤微环境的特点，介绍了微环境响应型碳点及其在肿瘤治疗中的应用研究进展。最后，对碳点在肿瘤治疗领域存在的挑战进行了展望。
Abstract
As a new carbon material, carbon dots have exhibited great potential in biomedical, energetic, and environmental applications due to their excellent optical characters, good biocompatibility and catalytic activities. Carbon dots(CDs) with red/near infrared(NIR) light responsive properties possess deep tissue penetration, minimal autofluorescence disturbance and low tissue damage, which makes them to be drawn great attention in biomedical application. In this review, we firstly introduced the factors affecting the absorption/emission properties of CDs, then focused on the recent advances of red/NIR light responsive CDs for the tumor therapy, mainly including photodynamic therapy(PDT), photothermal therapy(PTT) and PDT/PTT synergistic therapy. Meanwhile, based on the feature of tumor microenvironment, we also reviewed the tumor microenvironment(TME) responsive carbon dots and their applications in tumor therapy. Finally, we discussed the present challenges and future prospects of CDs for cancer treatment.
关键词
碳点光动力治疗光热治疗肿瘤微环境
Keywords
carbon dotsphotodynamic therapyphotothermal therapytumor microenvironment
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