单胺氧化酶荧光探针研究进展

王晓鹏; 李永东; 王建国

doi:10.37188/CJL.20210086

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单胺氧化酶荧光探针研究进展

特邀综述 | 更新时间：2021-07-22

- 单胺氧化酶荧光探针研究进展
  增强出版
- Research Progress of Fluorescent Probes for Monoamine Oxidases
- 发光学报 2021年42卷第7期页码：938-952
- 作者机构：
  
  1.赣南师范大学化学化工学院　江西省有机药物化学重点实验室，江西　赣州　 341000
  2.内蒙古大学化学化工学院　内蒙古精细有机合成重点实验室，内蒙古　呼和浩特　 010021
- 作者简介：
  
  [ "王晓鹏(1995-)，男，河北邢台人，硕士研究生，2018年于赣南师范大学获得学士学位，主要从事有机发光材料的合成及性能的研究。E-mail: 592046530@qq.com" ]
  [ "李永东(1972-)，男，江西赣州人，博士，教授，硕士研究生导师，2007年于中国科学院福建物质结构研究所获得博士学位，主要从事蛋白质化学及结构生物学的研究。E-mail: ydli2005@gmail.com" ]
  [ "王建国(1982-)，男，内蒙古兴和人，博士，研究员，博士研究生导师，2014年于中国科学院化学研究所获得博士学位，主要从事离子-π型有机光电功能材料(包括发光材料机理、有机室温磷光材料的开发与应用及光动力诊疗等)的研究。E-mail: wangjg@iccas.ac.cn" ]
- 基金信息：
  
  国家自然科学基金(21871060);内蒙古自治区自然科学基金(2020JQ02;2020MS02004);江西省自然科学基金(20192BCBL23013);内蒙古自治区草原英才项目资助
- DOI：10.37188/CJL.20210086
  中图分类号： O482.31
- 收稿：2021-03-12，
  
  修回：2021-04-02，
  
  纸质出版：2021-07-01
- 稿件说明：
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王晓鹏, 李永东, 王建国. 单胺氧化酶荧光探针研究进展[J]. 发光学报, 2021,42(7):938-952.

Xiao-peng WANG, Yong-dong LI, Jian-guo WANG. Research Progress of Fluorescent Probes for Monoamine Oxidases[J]. Chinese Journal of Luminescence, 2021, 42(7): 938-952.
王晓鹏, 李永东, 王建国. 单胺氧化酶荧光探针研究进展[J]. 发光学报, 2021,42(7):938-952. DOI： 10.37188/CJL.20210086.

Xiao-peng WANG, Yong-dong LI, Jian-guo WANG. Research Progress of Fluorescent Probes for Monoamine Oxidases[J]. Chinese Journal of Luminescence, 2021, 42(7): 938-952. DOI： 10.37188/CJL.20210086.

摘要

单胺氧化酶(Monoamine oxidases

MAOs)是一种膜结合的线粒体酶，通过催化氧化及脱氨反应来维持神经递质和其他生物胺在生物系统中的稳态。MAOs功能障碍与许多神经和精神疾病密切相关，因此，监测MAOs的活性及表达水平，对深入理解其生理功能及相关疾病的临床诊断都具有十分重要的意义。荧光探针具有原位、无创、可实时成像等优势，是准确监测MAOs活性的一种有效方法。本文综述了近年来MAOs荧光探针的研究进展，阐述了这些荧光探针在MAOs相关疾病诊断及治疗中的应用。

Abstract

Monoamine oxidases(MAOs) are a family of membrane-bound mitochondrial enzymes that play important roles in maintaining the homeostasis of neurotransmitters and other bioamines in the biological system through catalytic oxidation and deamination. The dysfunction of MAOs is closely related to many neurological and psychiatric disorders. Thus

monitoring the activity/level of MAOs is of great significance for deeply understanding their physiological functions and for clinical diagnosis of MAOs-related diseases. Fluorescent probes with the ability of

in situ

noninvasive and real-time imaging provide an effective method to accurately detect MAOs activity. In this review

the research progress of fluorescent probes for MAOs in recent years and their applications for the diagnosis and therapy of MAOs-related diseases are reviewed.

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Keywords

references

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