聚集诱导发光增强型金属纳米团簇在生物医学领域的研究进展

徐晗; 王宇昕; 景靳彭; 王一如; 孙文静; 陈洪敏

doi:10.37188/CJL.20200385

您当前的位置：

首页 >

文章列表页 >

聚集诱导发光增强型金属纳米团簇在生物医学领域的研究进展

特邀报告 | 更新时间：2021-03-19

- 聚集诱导发光增强型金属纳米团簇在生物医学领域的研究进展
- Progress on Metal Nanoclusters with Aggregation-induced Emission Characteristic in Biomedical Application
- 发光学报 2021年42卷第3期页码：336-347
- 作者机构：
  
  厦门大学分子疫苗学与分子诊断学国家重点实验室，分子影像暨转化医学研究中心，福建厦门　 361102
- 作者简介：
  
  [ "徐晗(1993－)，男，江苏泰州人，博士研究生，2019年于深圳大学获得硕士学位，主要从事分子影像和纳米材料制备的研究。E-mail: xuhanszu@163.com" ]
  [ "孙文静(1990－)，女，山东德州人，博士，特任副研究员，2019年于厦门大学获得博士学位，主要从事分子影像与纳米医学的研究。E-mail: sunwenjing1102@163.com" ]
  [ "陈洪敏(1982－)，男，山东日照人，教授，博士研究生导师，2009年于中国科学院理化技术研究所获得博士学位，主要从事功能影像探针的研究。E-mail: hchen@xmu.edu.cn" ]
- 基金信息：
  
  国家自然科学基金(81771977;82001956);博士后创新人才支持计划(BX20200196);厦门市科技发展计划(3502Z20183017);中央高校基本科研业务费专项资金(20720180054)
- DOI：10.37188/CJL.20200385
  中图分类号： O482.31
- 收稿日期：2020-12-15，
  
  修回日期：2021-02-02，
  
  纸质出版日期：2021-03-01
- 稿件说明：
移动端阅览
徐晗, 王宇昕, 景靳彭, 等. 聚集诱导发光增强型金属纳米团簇在生物医学领域的研究进展[J]. 发光学报, 2021,42(3):336-347.

Han XU, Yu-xin WANG, Jin-peng JING, et al. Progress on Metal Nanoclusters with Aggregation-induced Emission Characteristic in Biomedical Application[J]. Chinese journal of luminescence, 2021, 42(3): 336-347.
徐晗, 王宇昕, 景靳彭, 等. 聚集诱导发光增强型金属纳米团簇在生物医学领域的研究进展[J]. 发光学报, 2021,42(3):336-347. DOI： 10.37188/CJL.20200385.

Han XU, Yu-xin WANG, Jin-peng JING, et al. Progress on Metal Nanoclusters with Aggregation-induced Emission Characteristic in Biomedical Application[J]. Chinese journal of luminescence, 2021, 42(3): 336-347. DOI： 10.37188/CJL.20200385.

摘要

近年来，具有聚集诱导发光(Aggregation-induced emission

AIE)增强性质的金属纳米团簇由于其高光学稳定性和良好的发光性能在生物医学、环境科学等领域展现出广阔的应用前景。然而，当前对于AIE金属纳米团簇的研究还处于起步阶段，其复杂的表面/界面结构和增强发光机理尚不明晰，对其合理的调控制备仍是重要研究挑战之一。本文基于已成功合成的具有高AIE性能金属纳米团簇的研究报道，综述了硫醇修饰的表面修饰机理和策略；主要介绍了金、银、铜几种AIE金属纳米团簇在分析传感及生物医学领域的应用，并对其他配体修饰的铱配合物的AIE特性及其应用进行了论述；最后阐述了对AIE金属纳米团簇研究现状的看法及展望，旨在为AIE金属纳米团簇未来的研究发展提供思路与参考。

Abstract

Metal nanoclusters with enhanced aggregation-induced emission(AIE) have shown a broad application prospect in the bio-medical fields and environmental science. However

the current researches on AIE metal nanoclusters are still in the initial stage. The complex surface/interface structure and enhanced luminescence mechanisms are still not clear. Moreover

it remains a big challenge to prepare AIE metal nanoclusters with properly regulated properties. Following the reports that successfully synthesized metal clusters with AIE characteristic

this review firstly summarized the surface modification strategies with mercaptan and the AIE mechanism of gold

silver

copper nanoclusters

and introduced their biomedical applications. Then

the preparation and bio-application of unique iridium complexes with AIE property are also discussed. Finally

the research status and prospects of AIE metal nanoclusters are described. In sum

this review aims to provide concepts for the future research and development of AIE metal nanoclusters.

关键词

Keywords

references

SHANG L , XU J , NIENHAUS G U . Recent advances in synthesizing metal nanocluster-based nanocomposites for application in sensing,imaging and catalysis [J]. Nano Today , 2019 , 28 : 100767-1-23 .

COPP S M , SCHULTZ D , SWASEY S , et al . Magic numbers in DNA-stabilized fluorescent silver clusters lead to magic colors [J]. J. Phys. Chem. Lett. , 2014 , 5 ( 6 ): 959 - 963 .

LIN C A J , YANG T Y , LEE C H , et al . Synthesis,characterization,and bioconjugation of fluorescent gold nanoclusters toward biological labeling applications [J]. ACS Nano , 2009 , 3 ( 2 ): 395 - 401 .

LUO Z T , YUAN X , YU Y , et al . From aggregation-induced emission of Au(Ⅰ)-thiolate complexes to ultrabright Au(0)@Au(Ⅰ)-thiolate core-shell nanoclusters [J]. J. Am. Chem. Soc. , 2012 , 134 ( 40 ): 16662 - 16670 .

PYO K , THANTHIRIGE V D , KWAK K , et al . Ultrabright luminescence from gold nanoclusters:rigidifying the Au(Ⅰ)-thiolate shell [J]. J. Am. Chem. Soc. , 2015 , 137 ( 25 ): 8244 - 8250 .

WU Z N , YAO Q F , ZANG S Q , et al . Aggregation-induced emission in luminescent metal nanoclusters [J] Natl. Sci. Rev. , 2020 , doi: 10.1093/nsr/nwaa208 http://doi.org/10.1093/nsr/nwaa208 .

ZHOU M , HIGAKI T , HU G X , et al . Three-orders-of-magnitude variation of carrier lifetimes with crystal phase of gold nanoclusters [J]. Science , 2019 , 364 ( 6437 ): 279 - 282 .

JUNG J , KANG S , HAN Y K . Ligand effects on the stability of thiol-stabilized gold nanoclusters:Au25(SR)18-,Au38-(SR)24,and Au102(SR)44 [J]. Nanoscale , 2012 , 4 ( 14 ): 4206 - 4210 .

WANG J X , GOSWAMI N , SHU T , et al . pH-responsive aggregation-induced emission of Au nanoclusters and crystallization of the Au(Ⅰ)-thiolate shell [J]. Mater. Chem. Front. , 2018 , 2 ( 5 ): 923 - 928 .

WU Z N , LIU H W , LI T T , et al . Contribution of metal defects in the assembly induced emission of Cu nanoclusters [J]. J. Am. Chem. Soc. , 2017 , 139 ( 12 ): 4318 - 4321 .

WANG Z G , XIONG Y , KERSHAW S V , et al . In situ fabrication of flexible,thermally stable,large-area,strongly luminescent copper nanocluster/polymer composite films [J]. Chem. Mater. , 2017 , 29 ( 23 ): 10206 - 10211 .

CHEN C , LI R H , ZHU B S , et al . Highly luminescent inks:aggregation-induced emission of copper-iodine hybrid clusters [J]. Angew. Chem. Int. Ed. Engl. , 2018 , 57 ( 24 ): 7106 - 7110 .

HUANG R W , WEI Y S , DONG X Y , et al . Hypersensitive dual-function luminescence switching of a silver-chalcogenolate cluster-based metal-organic framework [J] Nat. Chem. , 2017 , 9 ( 7 ): 689 - 697 .

XUE F F , QU F , HAN W L , et al . Aggregation-induced emission enhancement of gold nanoclusters triggered by silicon nanoparticles for ratiometric detection of protamine and trypsin [J]. Anal. Chim. Acta , 2019 , 1046 : 170 - 178 .

WANG J X , LIN X F , SU L , et al . Chemical etching of pH-sensitive aggregation-induced emission-active gold nanoclusters for ultra-sensitive detection of cysteine [J]. Nanoscale , 2019 , 11 ( 1 ): 294 - 300 .

LI Z H , GUO S , LU C . A highly selective fluorescent probe for sulfide ions based on aggregation of Cu nanocluster induced emission enhancement [J]. Analyst , 2015 , 140 ( 8 ): 2719 - 2725 .

CHEN P C , LI Y C , MA J Y , et al . Size-tunable copper nanocluster aggregates and their application in hydrogen sulfide sensing on paper-based devices [J]. Sci. Rep. , 2016 , 6 : 24882-1-9 .

LI B Z , WANG X , SHEN X , et al . Aggregation-induced emission from gold nanoclusters for use as a luminescence-enhanced nanosensor to detect trace amounts of silver ions [J]. J. Colloid Interf. Sci. , 2016 , 467 : 90 - 96 .

韩冰雁 , 侯绪芬 , 相荣超 , 等 . 基于铜纳米簇的聚集诱导发光检测铅离子 [J]. 分析化学 , 2017 , 45 ( 1 ): 23 - 27 .

HAN B Y , HOU X F , XIANG R C , et al . Detection of lead ion based on aggregation-induced emission of copper nanoclusters [J]. Chin. J. Anal. Chem. , 2017 , 45 ( 1 ): 23 - 27 . (in Chinese)

CAO H Y , CHEN Z H , HUANG Y M . Copper nanocluster coupling europium as an off-to-on fluorescence probe for the determination of phosphate ion in water samples [J]. Talanta , 2015 , 143 : 450 - 456 .

XIE Z C , SUN P P , WANG Z , et al . Metal-organic gels from silver nanoclusters with aggregation-induced emission and fluorescence-to-phosphorescence switching [J]. Angew. Chem. Int. Ed. Engl. , 2020 , 59 ( 25 ): 9922 - 9927 .

LIU H L , HONG G S , LUO Z T , et al . Atomic-precision gold clusters for NIR-Ⅱ imaging [J]. Adv. Mater. , 2019 , 31 ( 46 ): 1901015-1-9 .

SONG X R , ZHU W , GE X G , et al . A new class of NIR-Ⅱ gold nanocluster-based protein biolabels for in vivo tumor-targeted imaging [J] Angew. Chem. Int. Ed. Engl. , 2021 , 60 ( 3 ): 1306 - 1312 .

ZHANG X D , CHEN J , LUO Z T , et al . Enhanced tumor accumulation of sub-2 nm gold nanoclusters for cancer radiation therapy [J] Adv. Healthc. Mater. , 2014 , 3 ( 1 ): 133 - 141 .

SUN W J , LUO L , FENG Y S , et al . Aggregation-induced emission gold clustoluminogens for enhanced low-dose X-ray-induced photodynamic therapy [J]. Angew. Chem. Int. Ed. Engl. , 2020 , 59 ( 25 ): 9914 - 9921 .

SAJOTO T , DJUROVICH P I , TAMAYO A B , et al . Temperature dependence of blue phosphorescent cyclometalated Ir(Ⅲ) complexes [J]. J. Am. Chem. Soc. , 2009 , 131 ( 28 ): 9813 - 9822 .

COSTA R D , ORTÍ E , BOLINK H J , et al . Intramolecular π-stacking in a phenylpyrazole-based iridium complex and its use in light-emitting electrochemical cells [J]. J. Am. Chem. Soc. , 2010 , 132 ( 17 ): 5978 - 5980 .

ZHAO Q , LIU S J , SHI M , et al . Series of new cationic iridium(Ⅲ) complexes with tunable emission wavelength and excited state properties:structures,theoretical calculations,and photophysical and electrochemical properties [J]. Inorg. Chem. , 2006 , 45 ( 16 ): 6152 - 6160 .

XIONG L Q , ZHAO Q , CHEN H L , et al . Phosphorescence imaging of homocysteine and cysteine in living cells based on a cationic iridium(Ⅲ) complex [J]. Inorg. Chem. , 2010 , 49 ( 14 ): 6402 - 6408 .

YU M X , ZHAO Q , SHI L X , et al . Cationic iridium(Ⅲ) complexes for phosphorescence staining in the cytoplasm of living cells [J]. Chem. Commun. , 2008 ( 18 ): 2115 - 2117 .

CHEN Y , QIAO L P , YU B L , et al . Mitochondria-specific phosphorescent imaging and tracking in living cells with an AIPE-active iridium(Ⅲ) complex [J]. Chem. Commun. , 2013 , 49 ( 94 ): 11095 - 11097 .

JIN C Z , LIU J P , CHEN Y , et al . Cyclometalated iridium(Ⅲ) complexes as AIE phosphorescent probes for real-time monitoring of mitophagy in living cells [J]. Sci. Rep. , 2016 , 6 : 22039-1-13 .

ALAM P , DAS P , CLIMENT C , et al . Facile tuning of the aggregation-induced emission wavelength in a common framework of a cyclometalated iridium(Ⅲ) complex:micellar encapsulated probe in cellular imaging [J]. J. Mater. Chem. C , 2014 , 2 ( 28 ): 5615 - 5628 .

浏览量

690

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

用于全氟辛烷磺酸盐检测的“开启”式荧光探针

含苯甲酸乙酯结构的共轭材料对硝基芳烃爆炸物的荧光检测

以二苯并吩嗪为核心的聚集诱导发红光材料制备及表征

近红外二区聚集诱导发光材料在手术导航上的应用

四苯乙烯类聚集诱导发光探针在生物分子检测领域的应用