聚集诱导发光探针用于线粒体靶向和癌细胞识别研究进展

彭嘉琪; 陈明; 秦安军; 唐本忠

doi:10.37188/CJL.20200351

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聚集诱导发光探针用于线粒体靶向和癌细胞识别研究进展

特邀报告 | 更新时间：2021-03-19

- 聚集诱导发光探针用于线粒体靶向和癌细胞识别研究进展
- Progress on Aggregation-induced Emission Probes for Mitochondria Target and Cancer Cell Identification
- 发光学报 2021年42卷第3期页码：348-360
- 作者机构：
  
  1.暨南大学化学与材料学院，广东广州　510632；
  2.华南理工大学发光材料与器件国家重点实验室，广东省分子聚集发光重点实验室，华南理工大学-香港科技大学联合研究院，广东广州　510640；
  3.香港科技大学化学系，人体组织功能重建国家工程技术研究中心香港分中心，中国香港　999077
- 作者简介：
  
  彭嘉琪(2000－)，女，湖南益阳人，在读本科生，主要从事AIE荧光探针的设计和应用开发的研究。E-mail: pjq0928@stu2018.jnu.edu.cn
  陈明(1986－)，男，江苏南通人，博士，副教授，2015年于浙江大学获得博士学位，之后在中国香港科技大学从事博士后研究，主要从事杂环聚集诱导发光分子的设计、开发及应用探索的研究。E-mail: chenming@jnu.edu.cn
  秦安军(1977－)，男，山西长治人，博士，教授，博士研究生导师，2004年于中国科学院化学研究所获得博士学位，主要从事基于三键单体的高分子合成化学以及有机/聚合物光电功能材料的制备及应用的研究。E-mail: msqinaj@scut.edu.cn
- 基金信息：
  
  国家自然科学基金(21905113;21788102;51620105009);广东省自然科学基金(2020A1515010622;2019B030301003;2016A030312002);香港创新及科技基金(ITC-CNERC14S01);中央高校基本科研业务费专项资金(21619316)
- DOI：10.37188/CJL.20200351
  中图分类号： O482.31
- 收稿：2020-11-15，
  
  修回：2020-12-05，
  
  纸质出版：2021-03-01
- 稿件说明：
移动端阅览
彭嘉琪, 陈明, 秦安军, 等. 聚集诱导发光探针用于线粒体靶向和癌细胞识别研究进展[J]. 发光学报, 2021,42(3):348-360.

Jia-qi PENG, Ming CHEN, An-jun QIN, et al. Progress on Aggregation-induced Emission Probes for Mitochondria Target and Cancer Cell Identification[J]. Chinese Journal of Luminescence, 2021, 42(3): 348-360.
彭嘉琪, 陈明, 秦安军, 等. 聚集诱导发光探针用于线粒体靶向和癌细胞识别研究进展[J]. 发光学报, 2021,42(3):348-360. DOI： 10.37188/CJL.20200351.

Jia-qi PENG, Ming CHEN, An-jun QIN, et al. Progress on Aggregation-induced Emission Probes for Mitochondria Target and Cancer Cell Identification[J]. Chinese Journal of Luminescence, 2021, 42(3): 348-360. DOI： 10.37188/CJL.20200351.

摘要

聚集诱导发光(Aggregation-induced emission，AIE)探针由于其极高的灵敏度和极佳的光稳定性在癌症诊断和治疗等方面具有不可估量的应用前景。线粒体作为所有细胞共有的重要细胞器，在癌细胞和正常细胞中显示出明显的性质区别，因此可作为线粒体靶向AIE探针区分癌细胞与正常细胞的靶标。本文介绍了线粒体靶向AIE探针的设计方法、成像机理以及它们对癌细胞与正常细胞、循环肿瘤细胞与白细胞以及癌细胞和相关细菌与正常细胞的区别成像。这些荧光探针在癌症诊断、手术导航、癌症治疗的效果评估和后续复发监测以及细胞污染评估等方面具有广阔的应用前景。通过本文的介绍，能够让更多读者了解AIE探针在癌细胞识别方面的显著优势，激发开发性能更为丰富的探针材料和开展更为深入的研究，从而促进生物医学领域的快速发展，造福人类。

Abstract

Aggregation-induced emission(AIE) probes have shown great potential in cancer diagnosis and therapy due to their excellent sensitivity and photo-stability. Mitochondria

which is regarded as one of the most important organelles in cells

has obvious difference between cancer cells and normal cells. Thus

it is reliable to utilize mitochondria-targeted AIE probes to distinguish cancer from normal cells. In this review

we exhibit the design principle and imaging mechanism of AIE probes for mitochondria target

and their distinguishing imaging between cancer cells and normal cells

circulating tumor cells and leukocyte

and dual identification imaging of cancer cells and related bacteria. The probes show remarkable advantages in cancer diagnosis

surgical navigation

cancer treatment assessment and recurrence monitoring

and cell pollution evaluation. We hope

this review will motivate to develop more AIE probes with rich properties and conduct deeper researches to promote the rapid development of biomedical field and maintain human health.

关键词

Keywords

references

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