长余辉纳米诊疗剂的设计策略与应用研究进展

康茹; 张绍安; 练惠旺; 陈星中; 李杨

doi:10.37188/CJL.20200275

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长余辉纳米诊疗剂的设计策略与应用研究进展

特邀报告 | 更新时间：2020-12-10

- 长余辉纳米诊疗剂的设计策略与应用研究进展
- Research Progress on Design Strategy and Application of Persistent Luminescence Nanotheranostics
- 发光学报 2020年41卷第12期页码：1614-1626
- 作者机构：
  
  1.广东工业大学物理与光电工程学院, 广东广州 510006
  2.广州医科大学生物医学工程系, 广东广州 511436
  3.广东技术师范大学光电工程学院, 广东广州 510665
- 作者简介：
  
  [ "康茹(1996-)，女，广东云浮人，硕士研究生，2018年于广东工业大学获得学士学位，主要从事长余辉发光材料相关方向的研究。E-mail：3214008594@mail2.gdut.edu.cn" ]
  [ "李杨(1984-)，男，山东淄博人，博士，教授，2014年于华南理工大学获得博士学位，主要从事无机发光材料设计、合成及应用方面的研究。E-mail：lychris@sina.com" ]
- 基金信息：
  
  国家自然科学基金(51602063);广东省自然科学基金(2019A030310444);广州市科技计划(2019A1515011688)
- DOI：10.37188/CJL.20200275
  中图分类号： O482.31
- 纸质出版日期：2020-12，
  
  收稿日期：2020-9-11，
  
  录用日期：2020-10-29
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康茹, 张绍安, 练惠旺, 等. 长余辉纳米诊疗剂的设计策略与应用研究进展[J]. 发光学报, 2020,41(12):1614-1626.

Ru KANG, Shao-an ZHANG, Hui-wang LIAN, et al. Research Progress on Design Strategy and Application of Persistent Luminescence Nanotheranostics[J]. Chinese Journal of Luminescence, 2020,41(12):1614-1626.
康茹, 张绍安, 练惠旺, 等. 长余辉纳米诊疗剂的设计策略与应用研究进展[J]. 发光学报, 2020,41(12):1614-1626. DOI： 10.37188/CJL.20200275.

Ru KANG, Shao-an ZHANG, Hui-wang LIAN, et al. Research Progress on Design Strategy and Application of Persistent Luminescence Nanotheranostics[J]. Chinese Journal of Luminescence, 2020,41(12):1614-1626. DOI： 10.37188/CJL.20200275.

摘要

长余辉纳米材料具有激发/发射分离、成像分辨率高、大面积成像与操作模式便捷等优点，在高灵敏度生物医学光学诊断领域引起了广泛关注。然而，随着诊疗一体化需求的增加，现有长余辉纳米材料功能的单一性阻碍了其在微型化、集成化诊疗上的快速发展。基于此，本综述针对生物医学诊疗集成一体化的长余辉纳米诊疗剂开发，展示了相应的设计策略和合成方法，并指出了长余辉纳米诊疗剂的研究前景、机遇及未来的发展方向。

Abstract

In virtue of the separation of excitation and emission

background-free autofluorescence

large area imaging and convenient operation

persistent luminescence nanoparticles(PLNPs) have attracted widespread attention in the field of optical diagnosis. However

with the increasing demand for integrated diagnosis and treatment

the single function of the existing PLNPs limits their technological breakthroughs in the miniaturized and integrated diagnosis and treatment units. Herein

in this review

PLNPs which can meet the integration requirements of biomedical diagnosis and treatment are discussed. Then the design strategies of developing these nanotheranostics are elaborated. Finally

the research opportunities for PLNPs nanotheranostics are prospected.

关键词

长余辉纳米诊疗剂生物成像药物治疗

Keywords

persistent luminescencenanotheranosticsbioimagingtreatment

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