离散偶极近似仿真金属调制稀土荧光及应用研究

吕锐婵; 王燕兴; 杨凡; 陈朝晖; 田捷; 林君

doi:10.37188/fgxb20204109.1030

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离散偶极近似仿真金属调制稀土荧光及应用研究

特邀综述 | 更新时间：2020-09-10

- 离散偶极近似仿真金属调制稀土荧光及应用研究
- Discrete Dipole Approximation Assisted Metal Modulation of Rare Earth Fluorescence and Application
- 发光学报 2020年41卷第9期页码：1030-1044
- 作者机构：
  
  1.西安电子科技大学分子与神经影像教育部工程中心, 智能传感交叉前沿研究中心, 生命科学技术学院, 机电工程学院, 陕西西安 710126
  2.中国科学院长春应用化学研究所稀土资源利用国家重点实验室, 吉林长春 130022
- 作者简介：
  
  [ "吕锐婵(1987-), 女, 河南孟津人, 博士, 教授, 2015年于哈尔滨工程大学获得博士学位, 主要从事稀土发光材料和抗癌诊疗的研究。E-mail:rclv@xidian.edu.cn" ]
  [ "田捷(1960-), 男, 安徽芜湖人, 博士, 教授, 博士研究生导师, 1993年于中国科学院自动化研究所获得博士学位, 主要从事分子影像、人工智能、智慧医疗等的研究。E-mail:tian@ieee.org" ]
  [ "林君(1966-), 男, 吉林长春人, 博士, 研究员, 博士研究生导师, 1995年于中国科学院化学研究所获得博士学位, 主要从事稀土发光、纳米医学等的研究。E-mail:jlin@ciac.ac.cn" ]
- 基金信息：
  
  国家自然科学基金(81801744);国家自然科学基金(91859202);国家自然科学基金(51720105015);国家重点研发计划(2018YFC0910602);国家重点研发计划(2017YFA0205200)
- DOI：10.37188/fgxb20204109.1030
  中图分类号： TP394.1;TH691.9
- 纸质出版日期：2020-9，
  
  收稿日期：2020-6-10，
  
  录用日期：2020-6-28
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吕锐婵, 王燕兴, 杨凡, 等. 离散偶极近似仿真金属调制稀土荧光及应用研究[J]. 发光学报, 2020,41(9):1030-1044.

Rui-chan LYU, Yan-xing WANG, Fan YANG, et al. Discrete Dipole Approximation Assisted Metal Modulation of Rare Earth Fluorescence and Application[J]. Chinese Journal of Luminescence, 2020,41(9):1030-1044.
吕锐婵, 王燕兴, 杨凡, 等. 离散偶极近似仿真金属调制稀土荧光及应用研究[J]. 发光学报, 2020,41(9):1030-1044. DOI： 10.37188/fgxb20204109.1030.

Rui-chan LYU, Yan-xing WANG, Fan YANG, et al. Discrete Dipole Approximation Assisted Metal Modulation of Rare Earth Fluorescence and Application[J]. Chinese Journal of Luminescence, 2020,41(9):1030-1044. DOI： 10.37188/fgxb20204109.1030.

摘要

上转换荧光材料由于具有独特的反斯托克斯发射、激发光成像深、自发荧光低、物理化学性质稳定等特点，因此作为影像药剂被广泛研究，在生物医疗领域的应用也得到了不断的发展，但较低的发光效率制约了其发展。金属纳米粒子具有独特的局域表面等离子共振效应，可以有效地增强上转换荧光。本文主要综述离散偶极近似仿真对金属调制荧光的理论指导、实验验证和生物应用。离散偶极近似仿真能够计算纳米粒子电磁特性，可以预测等离子共振峰的位置和强度，从而指导设计金属增强稀土荧光的结构，并对其荧光性能进行测试验证。综述中共涉及了六种不同的稀土-金属复合结构，都获得了金属增强荧光的效果，并实现了其在生物成像和治疗领域的应用。

Abstract

Up-conversion luminescence material has been widely studied as the imaging agent due to its unique characteristics of anti-Stokes emission

deep excitation light imaging

low background self-fluorescence

and stable physical/chemical property

thus its application has been developed gradually. However

the low efficiency restricts the application in the biomedical field of up-conversion luminescent materials. Metal nanoparticles have unique local surface plasmon resonance and can effectively enhance fluorescence intensity. In this paper

discrete dipole approximation simulation of metal modulation to rare earth from theoretical guidance and experimental verification to biological use were reviewed. The electromagnetic characteristics of the composite can be obtained by the simulation

and plasma resonance peak(position and intensity) can be predicted

in order to guide the design and synthesis with the final luminescence test validation. In this review

six typical different rare earth-metal composites were designed and synthesized with enhanced fluorescence effect

and the application in biological imaging and therapy field was implemented.

关键词

上转换荧光表面等离子共振近红外激光

Keywords

up-conversion luminescencesurface plasmon resonancenear infrared laser

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