Utilizing NIR AIE Luminogen Based Magnetic Nanoparticle for Light-enhanced Bacterial Killing

XIE Hong-qin; XIE Yang-zi; WANG Yue-ting; JIAO Zhe; GUO Zong-ning; HUANG Xue-lin; CHEN Ming; LUO Xiao-zheng

doi:10.37188/CJL.20220015

您当前的位置：

首页 >

文章列表页 >

Utilizing NIR AIE Luminogen Based Magnetic Nanoparticle for Light-enhanced Bacterial Killing

Luminescence Applications and Interdisciplinary Fields | 更新时间：2023-10-27

- Utilizing NIR AIE Luminogen Based Magnetic Nanoparticle for Light-enhanced Bacterial Killing
  增强出版
- Chinese Journal of Luminescence Vol. 43, Issue 10, Pages: 1628-1635(2022)
- 作者机构：
  
  1.广东省东莞生态环境监测站，广东东莞　523106
  2.东莞理工学院生态环境与建筑工程学院，广东东莞　523008
  3.黄埔海关技术中心，广东东莞　523000
  4.暨南大学化学与材料学院，广东广州　510632
- 作者简介：
- 基金信息：
  
  广东省科技厅海外名师项目(2021441900000);东莞市社会发展科技项目面上项目(20211800901582);东莞市科技特派员项目(20201800500172);广东省科技计划项目(2019507101162)
- DOI：10.37188/CJL.20220015
  CLC： O482.31
- Published：05 October 2022，
  
  Received：21 May 2022，
  
  Revised：06 June 2022，
扫描看全文
谢宏琴,谢样梓,王玥婷等.基于近红外聚集诱导发光分子的磁性纳米材料用于光增强杀菌[J].发光学报,2022,43(10):1628-163510.37188/CJL.20220015.

XIE Hong-qin,XIE Yang-zi,WANG Yue-ting,et al.Utilizing NIR AIE Luminogen Based Magnetic Nanoparticle for Light-enhanced Bacterial Killing[J].Chinese Journal of Luminescence,2022,43(10):1628-163510.37188/CJL.20220015.
谢宏琴,谢样梓,王玥婷等.基于近红外聚集诱导发光分子的磁性纳米材料用于光增强杀菌[J].发光学报,2022,43(10):1628-163510.37188/CJL.20220015. DOI：

XIE Hong-qin,XIE Yang-zi,WANG Yue-ting,et al.Utilizing NIR AIE Luminogen Based Magnetic Nanoparticle for Light-enhanced Bacterial Killing[J].Chinese Journal of Luminescence,2022,43(10):1628-163510.37188/CJL.20220015. DOI：

摘要

近红外光敏剂由于荧光成像具有光损伤小、穿透力强和空间分辨率高等优点，能显著提高光动力治疗效果。我们合成了近红外聚集诱导探针5，6‑2（4′‑（二苯氨酚）‑［1，1′‑联苯］‑4‑yl）吡嗪‑2，3‑二甲腈（DCDPP‑2TPA）用于光增强杀菌。利用聚集态/固态下荧光增强的优势，DCDPP‑2TPA与磁性Fe

纳米材料复合，产生更高活性氧（ROS）用于杀菌。利用SEM、TEM、XRD和荧光光谱研究了该复合材料的结构和性质，并用于大肠杆菌和金黄色葡萄球菌杀菌实验。结果表明，在光照下两种细菌的存活率为7.5%与9.0%，优于DCDPP⁃2TPA （10%与14%）。同时该复合材料可以方便地实现磁性分离，在光照下产生ROS后循环杀菌。

Abstract

NIR photosensitizers（PSs） could significantly improve the efficacy of photodynamic therapy due to the long-wavelength favorability for deeper tissue penetration and lower biological damage. In this paper， a deep-red emissive AIEgens 5，6-bis（4′-（diphenylamino）-［1，1′-biphenyl］-4-yl） pyrazine-2，3-dicarbonitrile（DCDPP-2TPA） was synthesized for light-enhanced bacterial killing. Due to the advantage of AIEgens which are ultra-emissive in the aggregate states or solid states， DCDPP-2TPA was incorporated into magnetic nanoparticle to increase aggregation enhanced reactive oxygen species（ROS） generation property as well as magnetic separation convenience. The magnetic particles were studied by scanning electron microscope（SEM）， transmission electron microscope（TEM）， X-ray diffraction（XRD）， and fluorescence spectrophotometer，

etc

. The capacity of bacterial killing was exhibited on

E.coli

and

S. aureus

under light irradiation. Due to the aggregation enhanced ROS generation， the viability of

E.coli

and

S. aureus

treated with DCDPP-2TPA based magnetic nanoparticle with room light illumination for 30 min are 7.5% and 9.0%， which was superior to DCDPP-2TPA（10% and 14% respectively）. The significant superiority of magnetic nanoparticles is that it can be withdrawn easily and continuously used for bacteria killing by applying light to induce ROS generation.

关键词

聚集诱导发光杀菌材料磁性纳米材料

Keywords

AIE luminogenmagnetic nanoparticlebacterial killing

references

RAY P C， KHAN S A， SINGH A K， et al. Nanomaterials for targeted detection and photothermal killing of bacteria ［J］. Chem. Soc. Rev.， 2012， 41（8）： 3193-3209. doi: 10.1039/c2cs15340hhttp://dx.doi.org/10.1039/c2cs15340h

MAZARI S A， ALI E， ABRO R， et al. Nanomaterials： applications， waste-handling， environmental toxicities， and future challenges-a review ［J］. J. Environ. Chem. Eng.， 2021， 9（2）： 105028. doi: 10.1016/j.jece.2021.105028http://dx.doi.org/10.1016/j.jece.2021.105028

XING C F， XU Q L， TANG H W， et al. Conjugated polymer/porphyrin complexes for efficient energy transfer and improving light-activated antibacterial activity ［J］. J. Am. Chem. Soc.， 2009， 131（36）： 13117-13124. doi: 10.1021/ja904492xhttp://dx.doi.org/10.1021/ja904492x

STRASSERT C A， OTTER M， ALBUQUERQUE R Q， et al. Photoactive hybrid nanomaterial for targeting， labeling， and killing antibiotic-resistant bacteria ［J］. Angew. Chem. Int. Ed.， 2009， 48（42）： 7928-7931. doi: 10.1002/anie.200902837http://dx.doi.org/10.1002/anie.200902837

PARK S Y， BAIK H J， OH Y T， et al. A smart polysaccharide/drug conjugate for photodynamic therapy ［J］. Chem. Angew. Int. Ed.， 2011， 50（7）： 1644-1647. doi: 10.1002/anie.201006038http://dx.doi.org/10.1002/anie.201006038

OHULCHANSKYY T Y， DONNELLY D J， DETTY M R， et al. Heteroatom substitution induced changes in excited-state photophysics and singlet oxygen generation in chalcogenoxanthylium dyes： effect of sulfur and selenium substitutions ［J］. J. Phys. Chem. B， 2004， 108（25）： 8668-8672. doi: 10.1021/jp0370674http://dx.doi.org/10.1021/jp0370674

WU W B， MAO D， HU F， et al. A highly efficient and photostable photosensitizer with near-infrared aggregation-induced emission for image-guided photodynamic anticancer therapy ［J］. Adv. Mater.， 2017， 29（33）： 1700548-1-7. doi: 10.1002/adma.201700548http://dx.doi.org/10.1002/adma.201700548

YUAN Z， LIN C C， HE Y， et al. Near-infrared light-triggered nitric-oxide-enhanced photodynamic therapy and low-temperature photothermal therapy for biofilm elimination ［J］. ACS Nano， 2020， 14（3）： 3546-3562. doi: 10.1021/acsnano.9b09871http://dx.doi.org/10.1021/acsnano.9b09871

ALMEIDA A， FAUSTINO M A F， TOMÉ J P C. Photodynamic inactivation of bacteria： finding the effective targets ［J］. Future Med. Chem.， 2015， 7（10）： 1221-1224. doi: 10.4155/fmc.15.59http://dx.doi.org/10.4155/fmc.15.59

LUO J D， XIE Z L， LAM J W Y， et al. Aggregation-induced emission of 1-methyl-1， 2， 3， 4， 5-pentaphenylsilole ［J］. Chem. Commun.， 2001（18）： 1740-1741. doi: 10.1039/b105159hhttp://dx.doi.org/10.1039/b105159h

MEI J， LEUNG N L C， KWOK R T K， et al. Aggregation-induced emission： together we shine， united we soar ［J］. Chem. Rev.， 2015， 115（21）： 11718-11940. doi: 10.1021/acs.chemrev.5b00263http://dx.doi.org/10.1021/acs.chemrev.5b00263

张志军，康苗苗，王媛玮，等. 聚集诱导发光材料在光学诊疗中的研究进展［J］. 发光学报， 2021， 42（3）： 361-378. doi: 10.37188/CJL.20210029http://dx.doi.org/10.37188/CJL.20210029

ZHANG Z J， KANG M M， WANG Y W， et al. Recent advances of aggregation-induced emission materials in phototheranostics ［J］. Chin. J. Lumin.， 2021， 42（3）： 361-378. （in Chinese）. doi: 10.37188/CJL.20210029http://dx.doi.org/10.37188/CJL.20210029

徐晗，王宇昕，景靳彭，等. 聚集诱导发光增强型金属纳米团簇在生物医学领域的研究进展［J］. 发光学报， 2021， 42（3）： 336-347. doi: 10.37188/CJL.20200385http://dx.doi.org/10.37188/CJL.20200385

XU H， WANG Y X， JING J P， et al. Progress on metal nanoclusters with aggregation-induced emission characteristic in biomedical application ［J］. Chin. J. Lumin.， 2021， 42（3）： 336-347. （in Chinese）. doi: 10.37188/CJL.20200385http://dx.doi.org/10.37188/CJL.20200385

彭嘉琪，陈明，秦安军，等. 聚集诱导发光探针用于线粒体靶向和癌细胞识别研究进展［J］. 发光学报， 2021， 42（3）： 348-360. doi: 10.37188/CJL.20200351http://dx.doi.org/10.37188/CJL.20200351

PENG J Q， CHEN M， QIN A J， et al. Progress on aggregation-induced emission probes for mitochondria target and cancer cell identification ［J］. Chin. J. Lumin.， 2021， 42（3）： 348-360. （in Chinese）. doi: 10.37188/CJL.20200351http://dx.doi.org/10.37188/CJL.20200351

WU Y H， CHEN Q X， LI Q Y， et al. Daylight-stimulated antibacterial activity for sustainable bacterial detection and inhibition ［J］. J. Mater. Chem. B， 2016， 4（38）： 6350-6357. doi: 10.1039/c6tb01629dhttp://dx.doi.org/10.1039/c6tb01629d

CHEN S， CHEN Q X， LI Q Y， et al. Biodegradable synthetic antimicrobial with aggregation-induced emissive luminogens for temporal antibacterial activity and facile bacteria detection ［J］. Chem. Mater.， 2018， 30（5）： 1782-1790. doi: 10.1021/acs.chemmater.8b00251http://dx.doi.org/10.1021/acs.chemmater.8b00251

WANG Y L， CHEN M， ALIFU N， et al. Aggregation-induced emission luminogen with deep-red emission for through-skull three-photon fluorescence imaging of mouse ［J］. ACS Nano， 2017， 11（10）： 10452-10461. doi: 10.1021/acsnano.7b05645http://dx.doi.org/10.1021/acsnano.7b05645

Views

192

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

Hongqin XIE

Yangzi XIE

Yueting WANG

Zhe JIAO

Zongning GUO

Xuelin HUANG

Ming CHEN

Related Institution

Guangdong Dongguan Ecological and Environmental Monitoring Station Dongguan

Address：No.3888 Dong Nanhu Road, Changchun, Jilin, China Postal code：130033
Tel：0431-86176862 Email：fgxbt@126.com
Technical support is provided by Beijing Founder electronics co., LTD 吉ICP备11002662号-17 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰