用作近红外光引导的化学‑光热协同治疗的上转换‑铋纳米诊疗剂

涂港; 凌丹萍; 刘杰; 汪丰; 王海芳; 施利毅; 孙丽宁

doi:10.37188/CJL.20220142

您当前的位置：

首页 >

文章列表页 >

用作近红外光引导的化学‑光热协同治疗的上转换‑铋纳米诊疗剂

材料合成及性能 | 更新时间：2022-08-01

- 用作近红外光引导的化学‑光热协同治疗的上转换‑铋纳米诊疗剂
  增强出版
- Upconversion-bismuth Nanosystem as Theranostic Agent for NIR Laser-driven Chemo-photothermal Therapy
- 发光学报 2022年43卷第7期页码：1040-1051
- 作者机构：
  
  1.上海大学理学院纳米科学与技术研究中心，上海　200444
  2.上海大学理学院化学系，上海　200444
  3.上海大学纳米化学与生物学研究所，上海　200444
- 作者简介：
  
  [ "涂港（1997-），男，湖北荆州人，硕士研究生，2019年于湖北大学获得学士学位，主要从事稀土上转换铋纳米体系的研究。Email: tugang@shu.edu.cnt" ]
  [ "施利毅（1963-），男，上海人，博士，教授，博士生导师，1999年于华东理工大学获得博士学位，主要从事纳米功能材料形态结构控制及工业化制备和应用技术的研究。" ]
  [ "孙丽宁（ 1979-），女，山东威海人，博士，教授/研究员，博士生导师， 2008 年于中国科学院长春应用化学研究所获得博士学位，主要从事稀土发光纳米材料及其生物成像和治疗、稀土杂化多功能材料及其发光机理、防伪和检测应用的研究。" ]
- 基金信息：
  
  National Natural Science Foundation of China(51872183);“Shuguang Program” supported by Shanghai Education Development Foundation and Shanghai Municipal Education Commission(19SG38)
- DOI：10.37188/CJL.20220142
  中图分类号： O482.31
- 纸质出版日期：2022-07-05，
  
  收稿日期：2022-04-18，
  
  修回日期：2022-04-28，
扫描看全文
涂港,凌丹萍,刘杰等.用作近红外光引导的化学‑光热协同治疗的上转换‑铋纳米诊疗剂[J].发光学报,2022,43(07):1040-1051.

TU Gang,LING Dan-ping,LIU Jie,et al.Upconversion-bismuth Nanosystem as Theranostic Agent for NIR Laser-driven Chemo-photothermal Therapy[J].Chinese Journal of Luminescence,2022,43(07):1040-1051.
涂港,凌丹萍,刘杰等.用作近红外光引导的化学‑光热协同治疗的上转换‑铋纳米诊疗剂[J].发光学报,2022,43(07):1040-1051. DOI： 10.37188/CJL.20220142.

TU Gang,LING Dan-ping,LIU Jie,et al.Upconversion-bismuth Nanosystem as Theranostic Agent for NIR Laser-driven Chemo-photothermal Therapy[J].Chinese Journal of Luminescence,2022,43(07):1040-1051. DOI： 10.37188/CJL.20220142.

摘要

设计并合成了一种用于近红外光驱动的化学⁃光热治疗的上转换⁃铋纳米体系诊疗剂（UBDAs），其具有出色的光热转换能力（28.5%）和良好的生物相容性。同时，在980 nm近红外光的激发下，UBDAs能够发射紫外/可见光，用于促进光敏剂偶氮苯在介孔中的连续旋转⁃翻转运动，从而实现药物的可控释放，且利用近红外光激发能够有效避免传统紫外光对生物组织的副作用。光热实验表明，UBDAs杂化纳米体系在980 nm激光照射下具有良好的光热效应。此外，含有Tm

和Bi元素的UBDAs有望用于上转换发光成像和X射线计算机断层成像，进而实现双模成像介导且单一近红外光激发的癌症化学疗法和光热疗法。该研究结果为诊断和协同增强抗肿瘤治疗的综合研究提供了新的思路。

Abstract

A hybrid nanosystem of upconversion-bismuth integration（denoted as UBDAs） is designed and synthesized for near infrared（NIR） light-driven chemo-photothermal therapy. The obtained UBDAs present excellent photothermal conversion capacity （~28.5%） and good biocompatibility. Meanwhile， under excitation of NIR， UBDAs can emit ultraviolet/visible light， which promotes the continuous rotation-flip movement of the photosensitizer azobenzene in the mesoporous， thereby achieving the controlled drug release and avoiding the side effects of traditional ultraviolet light excitation on biological tissues. Photothermal experiments show that UBDAs hybrid nanosystems have a good photothermal effect under 980 nm laser irradiation. In addition， based on Tm

and Bi element the UBDAs are expected to be used in upconversion luminescence and X-ray computed tomography（CT） imaging to achieve dual-mode imaging-mediated and single NIR-driven chemotherapy and photothermal therapy. Therefore， this work provides a new idea for the integration of diagnosis and synergistically enhanced antitumor therapy.

关键词

上转换发光成像光热治疗药物释放杂化纳米体系

Keywords

upconversion luminescenceimagingphotothermal therapydrug releasehybrid nanosystems

references

HOU B B，YANG W T，DONG C H，et al. Controlled co-release of doxorubicin and reactive oxygen species for synergistic therapy by NIR remote-triggered nanoimpellers ［J］. Mater. Sci. Eng. C‐Mater. Biol. Appl.， 2017，74：94-102. doi: 10.1016/j.msec.2017.02.016http://dx.doi.org/10.1016/j.msec.2017.02.016

THAKUR M K，GUPTA A，GHOSH S，et al. Graphene-conjugated upconversion nanoparticles as fluorescence-tuned photothermal nanoheaters for Desalination ［J］. ACS Appl. Nano Mater.， 2019，2（4）：2250-2259. doi: 10.1021/acsanm.9b00186http://dx.doi.org/10.1021/acsanm.9b00186

KUMAR B，MURALI A，MATTAN I，et al. Near-infrared-triggered photodynamic，photothermal，and on demand chemotherapy by multifunctional upconversionnanocomposite ［J］. J. Phys. Chem. B， 2019，123（17）：3738-3755. doi: 10.1021/acs.jpcb.9b01870http://dx.doi.org/10.1021/acs.jpcb.9b01870

HE Y C，NIU K，LUO L，et al. Reduction and protection：one-step synthesis of polydopamine-coated silver nanowires with superior biosafety for cancer treatment ［J］. ACS Sustainable Chem. Eng.， 2019，7（24）：20102-20106. doi: 10.1021/acssuschemeng.9b05965http://dx.doi.org/10.1021/acssuschemeng.9b05965

LIU Y，DING L，WANG D，et al. Hollow Pd nanospheres conjugated with Ce6 to simultaneously realize photodynamic and photothermal therapy ［J］. ACS Appl. Bio. Mater.， 2018，1（4）：1102-1108. doi: 10.1021/acsabm.8b00318http://dx.doi.org/10.1021/acsabm.8b00318

ZHANG H，WANG Y M，ZHONG H，et al. Near-infrared light-activated Pt@Au nanorings-based probe for fluorescence imaging and targeted photothermal therapy of cancer cells ［J］. ACS Appl. Bio. Mater.， 2019，2（11）：5012-5020. doi: 10.1021/acsabm.9b00712http://dx.doi.org/10.1021/acsabm.9b00712

ZHOU H，CHE L，GUO Z M，et al. Bacteria-mediated ultrathin Bi2Se3 nanosheets fabrication and their application in photothermal cancer therapy ［J］. ACS Sustainable Chem. Eng.， 2018，6（4）：4863-4870. doi: 10.1021/acssuschemeng.7b04321http://dx.doi.org/10.1021/acssuschemeng.7b04321

ZHANG HH，CHEN G H，YU B，et al. Fabrication of PEGy lated Bi2S3 nanosheets as a multifunctional platform for multimodal diagnosis and combination therapy for cancer ［J］. ACS Appl. Bio. Mater.， 2019，2（9）：3870-3876. doi: 10.1021/acsabm.9b00471http://dx.doi.org/10.1021/acsabm.9b00471

HUANG Y，HUANG J Q，JIANG M Y，et al. NIR-triggered theranostic Bi2S3 light transducer for on-demand NO release and synergistic gas/photothermal combination therapy of tumors ［J］. ACS Appl. Bio. Mater.， 2019，2（11）：4769-4776. doi: 10.1021/acsabm.9b00522http://dx.doi.org/10.1021/acsabm.9b00522

ZHANG M，WANG W T，CUI Y J，et al. Magnetofluorescent carbon quantum dot decorated multiwalled carbon nanotubes for dual-modal targeted imaging in chemo-photothermal synergistic therapy ［J］. ACS Biomater. Sci. Eng.， 2018，4（1）：151-162. doi: 10.1021/acsbiomaterials.7b00531http://dx.doi.org/10.1021/acsbiomaterials.7b00531

XUAN Y，YANG XQ，SONG ZY，et al. High‐security multifunctional nano‐bismuth‐sphere‐cluster prepared from oral gastric drug for CT/PA dual‐mode imaging and chemo‐photothermal combined therapy in vivo ［J］. Adv. Funct. Mater.， 2019，29（18）：1900017-1-12. doi: 10.1002/adfm.201900017http://dx.doi.org/10.1002/adfm.201900017

YU X J，LI A，ZHAO C Z，et al. Ultrasmall semimetal nanoparticles of bismuth for dual-modal computed tomography/photoacoustic imaging and synergistic thermoradiotherapy ［J］. ACS Nano， 2017，11（4）：3990-4001. doi: 10.1021/acsnano.7b00476http://dx.doi.org/10.1021/acsnano.7b00476

LEI PP，AN R，ZHANG P，et al. Ultrafast synthesis of ultrasmall poly（vinylpyrrolidone）-protected bismuth nanodots as a multifunctional theranostic agent for in vivo dual-modal CT/photothermal-imaging-guided photothermal therapy ［J］. Adv. Funct. Mater.， 2017，27（35）：1702018-1-10. doi: 10.1002/adfm.201702018http://dx.doi.org/10.1002/adfm.201702018

SONG Y，LIU G X，DONG X T，et al. Au Nanorods@NaGdF4/Yb3+，Er3+ multifunctional hybrid nanocomposites with upconversion luminescence，magnetism，and photothermal property ［J］. J. Phys. Chem. C， 2015，119（32）：18527-18536. doi: 10.1021/acs.jpcc.5b06099http://dx.doi.org/10.1021/acs.jpcc.5b06099

HUANG Y，XUE Z L，ZENG S J. Hollow mesoporous Bi@PEG-FA nanoshell as a novel dual-stimuli responsive nanocarrier for synergistic chemo-photothermal cancer therapy ［J］. ACS Appl. Mater. Interfaces， 2020，12（28）：31172-31181. doi: 10.1021/acsami.0c07372http://dx.doi.org/10.1021/acsami.0c07372

SUN L N，WEI R Y，FENG J，et al. Tailored lanthanide-doped upconversion nanoparticles and their promising bioapplication prospects ［J］. Coord. Chem. Rev.， 2018，364：10-32. doi: 10.1016/j.ccr.2018.03.007http://dx.doi.org/10.1016/j.ccr.2018.03.007

WANG K P，WU Q，WANG X C，et al. Near-infrared control and real-time detection of osteogenic differentiation in mesenchymal stem cells by multifunctional upconversion nanoparticles ［J］. Nanoscale， 2020，12（25）：10106-10116. doi: 10.1039/d0nr00872ahttp://dx.doi.org/10.1039/d0nr00872a

董娅慧，于佳酩，王士鹏，等. β-NaGdF4∶Yb3+，Er3+/纤维素纳米晶胆甾型复合膜制备及光学性能［J］. 发光学报， 2021，42（12）：1882-1890.

DONG Y H，YU J M，WANG S P，et al. Preparation and optical properties of β-NaGdF4∶Yb3+，Er3+/cellulose nanocrystalline cholesteric composite films ［J］. Chin. J. Lumin.， 2021，42（12）：1882-1890.（in Chinese）

赵皎印，索浩，李磊朋，等. 荧光热增强型稀土掺杂上转换发光材料研究进展［J］. 发光学报， 2021，42（11）：1673-1685. doi: 10.37188/CJL.20210265http://dx.doi.org/10.37188/CJL.20210265

ZHAO J Y，SUO H，LI L P，et al. Recent advances in rare-earth doped upconverisonmaterials with thermally-enhanced emissions ［J］. Chin. J. Lumin.， 2021，42（11）：1673-1685.（in Chinese）. doi: 10.37188/CJL.20210265http://dx.doi.org/10.37188/CJL.20210265

蒙铭周，张瑞，法信蒙，等. Ce3+掺杂对NaYF4∶Yb3+，Tm3+纳米粒子上转换发光性能的影响及其荧光温度特性应用［J］.发光学报， 2021，42（11）：1763-1773.

MENG M Z，ZHANG R，FA X M，et al. Effect of Ce3+ doping on upconversion luminescence of NaYF4∶Yb3+，Tm3+ nanoparticles and application of fluorescence temperature characteristics ［J］. Chin. J. Lumin.， 2021，42（11）：1763-1773.（in Chinese）

SUN X K，SUN J，DONG B，et al. Noninvasive temperature monitoring for dual-modal tumor therapy based on lanthanide-doped up-conversion nanocomposites ［J］. Biomaterials， 2019，201：42-52. doi: 10.1016/j.biomaterials.2019.02.014http://dx.doi.org/10.1016/j.biomaterials.2019.02.014

ZHOU B S，SUN X L，DONG B，et al. Antibacterial PDT nanoplatform capable of releasing therapeutic gas for synergistic and enhanced treatment against deep infections ［J］. Theranostics， 2022，12（6）：2580-2597. doi: 10.7150/thno.70277http://dx.doi.org/10.7150/thno.70277

CHEN B T，DONG B，WANG J，et al. Amphiphilic silane modified NaYF4∶Yb，Er loaded with Eu（TTA）3（TPPO）2 nanoparticles and their multi-functions：dual mode temperature sensing and cell imaging ［J］. Nanoscale， 2013，5（18）：8541-8549. doi: 10.1039/c3nr02670ahttp://dx.doi.org/10.1039/c3nr02670a

QI M L，LI X，SUN X L，et al. Novel nanotechnology and near-infrared photodynamic therapy to kill periodontitis-related biofilm pathogens and protect the periodontium ［J］. Dent. Mater.， 2019，35（11）：1665-1681. doi: 10.1016/j.dental.2019.08.115http://dx.doi.org/10.1016/j.dental.2019.08.115

LIU H Y，LI J B，HU P F，et al. Facile synthesis of Er3+/Tm3+ co-doped magnetic/luminescent nanosystems for possible bioimaging and therapy applications ［J］. J. Rare Earths， 2022，40（1）：11-19. doi: 10.1016/j.jre.2020.11.006http://dx.doi.org/10.1016/j.jre.2020.11.006

GE X Q，SUN L N，MA B B，et al. Simultaneous realization of Hg2+ sensing，magnetic resonance imaging and upconversion luminescence in vitro and in vivo bioimaging based on hollow mesoporous silica coated UCNPs and ruthenium complex ［J］. Nanoscale， 2015，7（33）：13877-13887. doi: 10.1039/c5nr04006jhttp://dx.doi.org/10.1039/c5nr04006j

WEI Z W，SUN L N，LIU J L，et al. Cysteine modified rare-earth up-converting nanoparticles for in vitro and in vivo bioimaging ［J］. Biomaterials， 2014，35（1）：387-392. doi: 10.1016/j.biomaterials.2013.09.110http://dx.doi.org/10.1016/j.biomaterials.2013.09.110

LIANG X，YE X Y，WANG C，et al. Photothermal cancer immunotherapy by erythrocyte membrane-coated black phosphorus formulation ［J］. J. Control Release， 2019，296：150-161. doi: 10.1016/j.jconrel.2019.01.027http://dx.doi.org/10.1016/j.jconrel.2019.01.027

XUE Y M，NIU W，WANG M，et al. Engineering a biodegradable multifunctional antibacterial bioactive nanosystem for enhancing tumor photothermo-chemotherapy and bone regeneration ［J］. ACS Nano， 2020，14（1）：442-453. doi: 10.1021/acsnano.9b06145http://dx.doi.org/10.1021/acsnano.9b06145

LV R C，JIANG X，YANG F，et al. Degradable magnetic-response photoacoustic/up-conversion luminescence imaging-guided photodynamic/photothermal antitumor therapy ［J］. Biomater. Sci.， 2019，7（11）：4558-4567. doi: 10.1039/c9bm00853ehttp://dx.doi.org/10.1039/c9bm00853e

LIU W L，ZOU M Z，LIU T，et al. Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells ［J］. Nat. Commun.， 2019，10：3199-1-12. doi: 10.1038/s41467-019-11157-1http://dx.doi.org/10.1038/s41467-019-11157-1

GOEBELER ME，BARGOU R C. T cell-engaging therapies-bitesand beyond ［J］. Nat. Rev. Clin. Oncol.， 2020，17（7）：418-434. doi: 10.1038/s41571-020-0347-5http://dx.doi.org/10.1038/s41571-020-0347-5

HAN X，SHEN S F，FAN Q，et al. Red blood cell-derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy ［J］. Sci. Adv.， 2019，5（10）：eaaw6870-1-9. doi: 10.1126/sciadv.aaw6870http://dx.doi.org/10.1126/sciadv.aaw6870

PAN J，HU P，GUO Y D，et al. Combined magnetic hyperthermia and immune therapy for primary and metastatic tumor treatments ［J］. ACS Nano， 2020，14（1）：1033-1044. doi: 10.1021/acsnano.9b08550http://dx.doi.org/10.1021/acsnano.9b08550

FENG Y，CHEN H D，SHAO B Q，et al. Renal-clearable peptide-functionalized Ba2GdF7 nanoparticles for positive tumor-targeting dual-mode bioimaging ［J］. ACS Appl. Mater. Interfaces， 2018，10（30）：25511-25518. doi: 10.1021/acsami.8b07129http://dx.doi.org/10.1021/acsami.8b07129

SUI B Y，LIU X，SUN J. Dual-dunctional dendritic mesoporous bioactive glass nanospheres for calcium influx-mediated specific tumor suppression and controlled drug delivery in vivo ［J］. ACS Appl. Mater. Interfaces， 2018，10（28）：23548-23559. doi: 10.1021/acsami.8b05616http://dx.doi.org/10.1021/acsami.8b05616

GONG Q Y，XING J，HUANG Y J，et al. Perylene diimideoligomer nanoparticles with ultrahigh photothermal conversion efficiency for cancer theranostics ［J］. ACS Appl. Bio. Mater.， 2020，3（3）：1607-1615. doi: 10.1021/acsabm.9b01187http://dx.doi.org/10.1021/acsabm.9b01187

ZHOU K，QIU X Y，XU L T，et al. Poly（selenoviologen） assembled upconversion nanoparticles for low power single NIR light triggered synergistic photodynamic and photothermal antibacterial therapy［J］. ACS Appl. Mater. Interfaces， 2020，12（23）：26432-26443. doi: 10.1021/acsami.0c04506http://dx.doi.org/10.1021/acsami.0c04506

CHEN Q，HUANG G J，WU W T，et al. A hybrid eukaryotic-prokaryotic nanoplatform with photothermal modality for enhanced antitumor vaccination ［J］. Adv. Mater.， 2020，32（16）：1908185-1-10. doi: 10.1002/adma.201908185http://dx.doi.org/10.1002/adma.201908185

ZHAO S，TIAN R R，SHAO B Q，et al. Designing of UCNPs@Bi@SiO2 hybrid theranostic nanoplatforms for simultaneous multimodal imaging and photothermal therapy ［J］. ACS Appl. Mater. Interfaces， 2019，11（1）：394-402. doi: 10.1021/acsami.8b19304http://dx.doi.org/10.1021/acsami.8b19304

XUE Y M，DU Y Z，YAN J，et al. Monodisperse photoluminescent and highly biocompatible bioactive glass nanoparticles for controlled drug delivery and cell imaging ［J］. J. Mater. Chem. B， 2015，3（18）：3831-3839. doi: 10.1039/c5tb00204dhttp://dx.doi.org/10.1039/c5tb00204d

CAI X J，JIA X Q，GAO W，et al. A versatile nanotheranosticagent for efficient dual-mode imaging guided synergistic chemo-thermal tumor therapy ［J］. Adv. Funct. Mater.， 2015，25（17）：2520-2529. doi: 10.1002/adfm.201403991http://dx.doi.org/10.1002/adfm.201403991

ZHANG Y F，WAN Y L，CHEN Y T，et al. Ultrasound-enhanced chemo-photodynamic combination therapy by using albumin “Nanoglue”-based nanotheranostics ［J］. ACS Nano， 2020，14（5）：5560-5569. doi: 10.1021/acsnano.9b09827http://dx.doi.org/10.1021/acsnano.9b09827

浏览量

213

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

发光学报 | 多模发光稀土掺杂纳米晶用于多维信息编码安全

Narrowband 1 550 nm Photodetection Based on Plasmon-enhanced Upconversion Luminescence

Enhancing Single-band Red Upconversion Luminescence of Ho³⁺ Through Dye-sensitization

Distinct Thermal Quenching of Upconversion and Downshifting Luminescence Caused by Dynamic Defects in Ion-conductive Na₃Sc₂（PO₄）₃: Yb³⁺, Er³⁺ Phosphor