With the rapid development of stretchable and wearable electronic devices, organic semiconductors have attracted much attention in the research field of stretchable optoelectronic devices due to their designable and controllable molecular structure, optoelectronic properties, and mechanical stretchability. The core goal of studying intrinsically stretchable organic semiconductor materials is how to improve their stretchability without sacrificing their optoelectronic properties. To this end, scholars have developed various strategies, including main chain and side chain engineering, optimizing molecular weight, as well as blending with elastomers, crosslinking agents, and adding plasticizers. Significant progress has been made in related research results. Organic semiconductors can not only achieve high stretchability, but also show good stability in repeated stretching/releasing process. However, there is still a gap in the optoelectronic performance of intrinsically stretchable organic semiconductors compared to non-stretchable materials. Therefore, more research is needed to reveal the stretching mechanism of organic semiconductor materials, strategies and methods to improve the optoelectronic performance of organic semiconductor thin films and related devices. Given the importance of intrinsically stretchable organic semiconductor research and the current challenges it faces, this article reviews the research progress in improving the tensile properties of organic semiconductor materials through molecular structure design and multi-component systems in the past decade, hoping to contribute to the further development of stretchable organic semiconductors and related optoelectronic devices.