<italic style="font-style: italic">Thea Viridis</italic> Derived Carbon Dots for Drug-resistant Bacterial Infections by Photodynamic Therapy

ZHANG Yunxiu; JIA Qingyan; GE Jiechao

doi:10.37188/CJL.20230036

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Thea Viridis Derived Carbon Dots for Drug-resistant Bacterial Infections by Photodynamic Therapy

Luminescence Applications and Interdisciplinary Fields | 更新时间：2023-10-27

- Thea Viridis Derived Carbon Dots for Drug-resistant Bacterial Infections by Photodynamic Therapy
  增强出版
- Chinese Journal of Luminescence Vol. 44, Issue 6, Pages: 1112-1120(2023)
- 作者机构：
  
  1.中国科学院理化技术研究所光化学转换与功能材料重点实验室，北京　100190
  2.中国科学院大学未来技术学院，北京　100049
  3.西北工业大学柔性电子前沿科学中心，陕西西安　710129
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China(52272052;51972315;52273302)
- DOI：10.37188/CJL.20230036
  CLC： Q819
- Published：05 June 2023，
  
  Received：15 February 2023，
  
  Revised：06 March 2023，
- 稿件说明：
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张云秀,贾庆岩,葛介超.绿茶衍生碳点用于光动力治疗耐药菌感染[J].发光学报,2023,44(06):1112-1120.

ZHANG Yunxiu,JIA Qingyan,GE Jiechao.Thea Viridis Derived Carbon Dots for Drug-resistant Bacterial Infections by Photodynamic Therapy[J].Chinese Journal of Luminescence,2023,44(06):1112-1120.
张云秀,贾庆岩,葛介超.绿茶衍生碳点用于光动力治疗耐药菌感染[J].发光学报,2023,44(06):1112-1120. DOI： 10.37188/CJL.20230036.

ZHANG Yunxiu,JIA Qingyan,GE Jiechao.Thea Viridis Derived Carbon Dots for Drug-resistant Bacterial Infections by Photodynamic Therapy[J].Chinese Journal of Luminescence,2023,44(06):1112-1120. DOI： 10.37188/CJL.20230036.

摘要

随着细菌耐药性的不断播散，尤其是“超级细菌”的出现，临床可用抗生素药物越来越少，迫切需要发展新的高效、低毒和无耐药性的抗菌材料和技术。本研究采用生物质绿茶作为碳源，通过溶剂热法，成功制备了具有光动力治疗（Photodynamic therapy，PDT）性能的绿茶衍生碳点（T⁃CDs）。在660 nm激光照射下，所制备的T⁃CDs 能够有效产生活性氧。细胞和活体实验表明，T⁃CDs具有优异的生物相容性，且产生的活性氧能杀死耐甲氧西林金黄色葡萄球菌，从而通过降低细菌引起的伤口炎症，加速伤口愈合。本研究所制备的T⁃CDs能够通过PDT杀灭致病菌，促进感染伤口愈合，为开发抗生素替代药物提供了新的思路，同时对探索耐药菌感染伤口临床治疗新方案具有重要参考价值。

Abstract

With the spread of bacterial drug resistance， especially the emergence of “superbugs”， it's an urgent need to develop new antibacterial materials and technologies with high efficiency， low toxicity and no drug resistance. In this study，

thea viridis

derived carbon dots （T-CDs） were successfully prepared by solvothermal method. Under 660 nm laser irradiation， the prepared T-CDs could effectively produce reactive oxygen species （ROS）.

In vitro

and

in vivo

experiments showed that T-CDs have excellent biocompatibility， and can produce ROS under laser irradiation to kill methicillin-resistant

Staphylococcus aureus

， thereby reducing wound inflammation caused by bacteria and accelerating wound healing. The prepared T-CDs can kill pathogenic bacteria through PDT and promote the healing of infected wounds， provide a new idea for the development of antibiotic replacement drugs， and have important value for exploring new clinical treatment schemes of drug-resistant bacteria infected wounds.

关键词

碳点光动力治疗耐药菌感染生物质

Keywords

carbon dotsphotodynamic therapydrug-resistant bacteriabiomass

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ZHANG Yunxiu

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Related Institution

Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices， Technical Institute of Physics and Chemistry， Chinese Academy of Sciences

Frontiers Science Center for Flexible Electronics （FSCFE）， Xi’an Institute of Flexible Electronics （IFE） and Xi’an Institute of Biomedical Materials & Engineering （IBME）， Northwestern Polytechnical University， 127 West Youyi Road

School of future technology， University of Chinese Academy of Sciences

School of Applied Science， Taiyuan University of Science and Technology

Hospital of Stomatology， Shanxi Medical University

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⁰

Thea Viridis Derived Carbon Dots for Drug-resistant Bacterial Infections by Photodynamic Therapy

DOI：10.37188/CJL.20230036

摘要

Abstract

关键词

Keywords

references