Application of NIR-Ⅱ Aggregation Induced Emission Materials in Surgical Navigation

LIU Xiaochun; LI Hairong; TANG Hui; LYU Yajing; ZHANG Yahui; WANG Zhouyu

doi:10.37188/CJL.20220432

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Application of NIR-Ⅱ Aggregation Induced Emission Materials in Surgical Navigation

Luminescence Applications and Interdisciplinary Fields | 更新时间：2023-05-10

- Application of NIR-Ⅱ Aggregation Induced Emission Materials in Surgical Navigation
  增强出版
- Chinese Journal of Luminescence Vol. 44, Issue 4, Pages: 717-728(2023)
- 作者机构：
  
  西华大学理学院，四川成都　610039
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China(21905021);Sichuan Province Science and Technology Support Program(2022NSFSC1269;2023NSFSC1977)
- DOI：10.37188/CJL.20220432
  CLC： O482.31
- Published：05 April 2023，
  
  Received：29 December 2022，
  
  Revised：09 January 2023，
- 稿件说明：
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刘小春,李海蓉,唐会等.近红外二区聚集诱导发光材料在手术导航上的应用[J].发光学报,2023,44(04):717-728.

LIU Xiaochun,LI Hairong,TANG Hui,et al.Application of NIR-Ⅱ Aggregation Induced Emission Materials in Surgical Navigation[J].Chinese Journal of Luminescence,2023,44(04):717-728.
刘小春,李海蓉,唐会等.近红外二区聚集诱导发光材料在手术导航上的应用[J].发光学报,2023,44(04):717-728. DOI： 10.37188/CJL.20220432.

LIU Xiaochun,LI Hairong,TANG Hui,et al.Application of NIR-Ⅱ Aggregation Induced Emission Materials in Surgical Navigation[J].Chinese Journal of Luminescence,2023,44(04):717-728. DOI： 10.37188/CJL.20220432.

摘要

临床手术仍然是治疗疾病的主要办法之一，而目前外科手术中医生难以通过肉眼观察、超声等方法确定肿瘤边界、残余病灶以及微小转移病灶，这些传统方法在很大程度上可能会造成癌症术后复发。近红外二区聚集诱导发光（NIR⁃Ⅱ AIE）材料作为荧光手术导航试剂，其快速发展为解决这个问题提供了新的技术支持。本文基于NIR⁃Ⅱ AIE分子的结构设计，通过分析其结构，依据NIR⁃Ⅱ AIE荧光在手术导航中的研究进展，分别就NIR⁃Ⅱ AIE材料在肿瘤切除手术、检测切除淋巴结手术以及在其他组织中的应用进行详细分析，讨论了目前存在的一些问题，并对NIR⁃Ⅱ AIE材料手术导航应用的未来发展进行了展望。

Abstract

Clinical surgery is one of the main methods to treat diseases. At present， visual observation and ultrasonic technology are commonly used by surgeons to determine tumor boundaries， residual lesions and micrometastasis lesions， which probably cause cancer recurrence to a large extent. The rapid development of the second near-infrared （NIR-Ⅱ） aggregation-induced emission （AIE） materials as fluorescent surgery navigation reagents provides new avenue to solve the problem. In this review， structural design of NIR-Ⅱ AIE materials in surgical navigation is first summarized. Then the applications of NIR-Ⅱ AIE material in tumor resection surgery， in detection of lymph node resection surgery， and in other tissues are discussed. At last， the future development of NIR-Ⅱ AIE materials in surgical navigation is prospected.

关键词

近红外二区聚集诱导发光手术导航供体受体

Keywords

the second near-infraredaggregation-induced emissionsurgical navigationdonoracceptor

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