Upconversion-bismuth Nanosystem as Theranostic Agent for NIR Laser-driven Chemo-photothermal Therapy

Gang TU; Dan-ping LING; Jie LIU; Feng WANG; Hai-fang WANG; Li-yi SHI; Li-ning SUN

doi:10.37188/CJL.20220142

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Upconversion-bismuth Nanosystem as Theranostic Agent for NIR Laser-driven Chemo-photothermal Therapy

更新时间：2022-08-01

- Upconversion-bismuth Nanosystem as Theranostic Agent for NIR Laser-driven Chemo-photothermal Therapy
  增强出版
- Chinese Journal of Luminescence Vol. 43, Issue 7, Pages: 1040-1051(2022)
- 作者机构：
  
  1.上海大学理学院纳米科学与技术研究中心，上海　200444
  2.上海大学理学院化学系，上海　200444
  3.上海大学纳米化学与生物学研究所，上海　200444
- 作者简介：
- 基金信息：
  
  国家自然科学基金(51872183);上海市教育委员会和上海市教育发展基金会“曙光计划”(19SG38)
- DOI：10.37188/CJL.20220142
  CLC： O482.31
- Published：05 July 2022，
  
  Received：18 April 2022，
  
  Revised：28 April 2022，
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涂港,凌丹萍,刘杰等.用作近红外光引导的化学‑光热协同治疗的上转换‑铋纳米诊疗剂[J].发光学报,2022,43(07):1040-1051.

TU Gang,LING Dan-ping,LIU Jie,et al.Upconversion-bismuth Nanosystem as Theranostic Agent for NIR Laser-driven Chemo-photothermal Therapy[J].Chinese Journal of Luminescence,2022,43(07):1040-1051.
涂港,凌丹萍,刘杰等.用作近红外光引导的化学‑光热协同治疗的上转换‑铋纳米诊疗剂[J].发光学报,2022,43(07):1040-1051. DOI： 10.37188/CJL.20220142.

TU Gang,LING Dan-ping,LIU Jie,et al.Upconversion-bismuth Nanosystem as Theranostic Agent for NIR Laser-driven Chemo-photothermal Therapy[J].Chinese Journal of Luminescence,2022,43(07):1040-1051. DOI： 10.37188/CJL.20220142.

摘要

设计并合成了一种用于近红外光驱动的化学⁃光热治疗的上转换⁃铋纳米体系诊疗剂（UBDAs），其具有出色的光热转换能力（28.5%）和良好的生物相容性。同时，在980 nm近红外光的激发下，UBDAs能够发射紫外/可见光，用于促进光敏剂偶氮苯在介孔中的连续旋转⁃翻转运动，从而实现药物的可控释放，且利用近红外光激发能够有效避免传统紫外光对生物组织的副作用。光热实验表明，UBDAs杂化纳米体系在980 nm激光照射下具有良好的光热效应。此外，含有Tm

和Bi元素的UBDAs有望用于上转换发光成像和X射线计算机断层成像，进而实现双模成像介导且单一近红外光激发的癌症化学疗法和光热疗法。该研究结果为诊断和协同增强抗肿瘤治疗的综合研究提供了新的思路。

Abstract

A hybrid nanosystem of upconversion-bismuth integration（denoted as UBDAs） is designed and synthesized for near infrared（NIR） light-driven chemo-photothermal therapy. The obtained UBDAs present excellent photothermal conversion capacity （~28.5%） and good biocompatibility. Meanwhile， under excitation of NIR， UBDAs can emit ultraviolet/visible light， which promotes the continuous rotation-flip movement of the photosensitizer azobenzene in the mesoporous， thereby achieving the controlled drug release and avoiding the side effects of traditional ultraviolet light excitation on biological tissues. Photothermal experiments show that UBDAs hybrid nanosystems have a good photothermal effect under 980 nm laser irradiation. In addition， based on Tm

and Bi element the UBDAs are expected to be used in upconversion luminescence and X-ray computed tomography（CT） imaging to achieve dual-mode imaging-mediated and single NIR-driven chemotherapy and photothermal therapy. Therefore， this work provides a new idea for the integration of diagnosis and synergistically enhanced antitumor therapy.

关键词

上转换发光成像光热治疗药物释放杂化纳米体系

Keywords

upconversion luminescenceimagingphotothermal therapydrug releasehybrid nanosystems

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