Utilizing NIR AIE Luminogen Based Magnetic Nanoparticle for Light-enhanced Bacterial Killing

XIE Hong-qin; XIE Yang-zi; WANG Yue-ting; JIAO Zhe; GUO Zong-ning; HUANG Xue-lin; CHEN Ming; LUO Xiao-zheng

doi:10.37188/CJL.20220015

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Utilizing NIR AIE Luminogen Based Magnetic Nanoparticle for Light-enhanced Bacterial Killing

Luminescence Applications and Interdisciplinary Fields | 更新时间：2023-10-27

- Utilizing NIR AIE Luminogen Based Magnetic Nanoparticle for Light-enhanced Bacterial Killing
  增强出版
- Chinese Journal of Luminescence Vol. 43, Issue 10, Pages: 1628-1635(2022)
- 作者机构：
  
  1.广东省东莞生态环境监测站，广东东莞　523106
  2.东莞理工学院生态环境与建筑工程学院，广东东莞　523008
  3.黄埔海关技术中心，广东东莞　523000
  4.暨南大学化学与材料学院，广东广州　510632
- 作者简介：
- 基金信息：
  
  广东省科技厅海外名师项目(2021441900000);东莞市社会发展科技项目面上项目(20211800901582);东莞市科技特派员项目(20201800500172);广东省科技计划项目(2019507101162)
- DOI：10.37188/CJL.20220015
  CLC： O482.31
- Published：05 October 2022，
  
  Received：21 May 2022，
  
  Revised：06 June 2022，
- 稿件说明：
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谢宏琴,谢样梓,王玥婷等.基于近红外聚集诱导发光分子的磁性纳米材料用于光增强杀菌[J].发光学报,2022,43(10):1628-163510.37188/CJL.20220015.

XIE Hong-qin,XIE Yang-zi,WANG Yue-ting,et al.Utilizing NIR AIE Luminogen Based Magnetic Nanoparticle for Light-enhanced Bacterial Killing[J].Chinese Journal of Luminescence,2022,43(10):1628-163510.37188/CJL.20220015.
谢宏琴,谢样梓,王玥婷等.基于近红外聚集诱导发光分子的磁性纳米材料用于光增强杀菌[J].发光学报,2022,43(10):1628-163510.37188/CJL.20220015. DOI：

XIE Hong-qin,XIE Yang-zi,WANG Yue-ting,et al.Utilizing NIR AIE Luminogen Based Magnetic Nanoparticle for Light-enhanced Bacterial Killing[J].Chinese Journal of Luminescence,2022,43(10):1628-163510.37188/CJL.20220015. DOI：

摘要

近红外光敏剂由于荧光成像具有光损伤小、穿透力强和空间分辨率高等优点，能显著提高光动力治疗效果。我们合成了近红外聚集诱导探针5，6‑2（4′‑（二苯氨酚）‑［1，1′‑联苯］‑4‑yl）吡嗪‑2，3‑二甲腈（DCDPP‑2TPA）用于光增强杀菌。利用聚集态/固态下荧光增强的优势，DCDPP‑2TPA与磁性Fe

纳米材料复合，产生更高活性氧（ROS）用于杀菌。利用SEM、TEM、XRD和荧光光谱研究了该复合材料的结构和性质，并用于大肠杆菌和金黄色葡萄球菌杀菌实验。结果表明，在光照下两种细菌的存活率为7.5%与9.0%，优于DCDPP⁃2TPA （10%与14%）。同时该复合材料可以方便地实现磁性分离，在光照下产生ROS后循环杀菌。

Abstract

NIR photosensitizers（PSs） could significantly improve the efficacy of photodynamic therapy due to the long-wavelength favorability for deeper tissue penetration and lower biological damage. In this paper， a deep-red emissive AIEgens 5，6-bis（4′-（diphenylamino）-［1，1′-biphenyl］-4-yl） pyrazine-2，3-dicarbonitrile（DCDPP-2TPA） was synthesized for light-enhanced bacterial killing. Due to the advantage of AIEgens which are ultra-emissive in the aggregate states or solid states， DCDPP-2TPA was incorporated into magnetic nanoparticle to increase aggregation enhanced reactive oxygen species（ROS） generation property as well as magnetic separation convenience. The magnetic particles were studied by scanning electron microscope（SEM）， transmission electron microscope（TEM）， X-ray diffraction（XRD）， and fluorescence spectrophotometer，

etc

. The capacity of bacterial killing was exhibited on

E.coli

and

S. aureus

under light irradiation. Due to the aggregation enhanced ROS generation， the viability of

E.coli

and

S. aureus

treated with DCDPP-2TPA based magnetic nanoparticle with room light illumination for 30 min are 7.5% and 9.0%， which was superior to DCDPP-2TPA（10% and 14% respectively）. The significant superiority of magnetic nanoparticles is that it can be withdrawn easily and continuously used for bacteria killing by applying light to induce ROS generation.

关键词

聚集诱导发光杀菌材料磁性纳米材料

Keywords

AIE luminogenmagnetic nanoparticlebacterial killing

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