Sensitive Detection of Captopril Based on “Off-On” Carbon Dots as Fluorescent Probe

Qian LIANG; Yu-lin WANG; Mei-qin ZHENG; Yan-xi CHEN; Wen-jie HUANG; Guang-man LI; Biao HUANG

doi:10.37188/CJL.20210372

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Sensitive Detection of Captopril Based on “Off-On” Carbon Dots as Fluorescent Probe

Luminescence Applications and Interdisciplinary Fields | 更新时间：2022-04-07

- Sensitive Detection of Captopril Based on “Off-On” Carbon Dots as Fluorescent Probe
  增强出版
- 发光学报 Vol. 43, Issue 3, Pages: 430-439(2022)
- 作者机构：
  
  1.福建农林大学金山学院，福建　福州　350002
  2.福建农林大学，福建　福州　350002
  3.重庆海关技术中心，重庆　401147
- 作者简介：
  
  [ "梁倩(1984-)，女，河北石家庄人，博士，讲师，2020年于福建农林大学获得博士学位，主要从事碳量子点荧光材料合成及传感的研究。E-mail: lqfafu@163.com" ]
  [ "黄彪(1966-)，男，福建古田县人，博士，教授，博士生导师，2004年于南京林业大学获得博士学位，主要从事生物质化学工程、生物质材料与能源等领域的研究。E-mail: bhuang@fafu.edu.cn" ]
- 基金信息：
  
  国家重点研发计划(2017YFD0601006);福建省教育厅项目(kz180414;JT180846)
- DOI：10.37188/CJL.20210372
  CLC： O482.31
- Published：2022-03，
  
  Received：29 November 2021，
  
  Revised：24 December 2021，
- 稿件说明：
移动端阅览
QIAN LIANG, YU-LIN WANG, MEI-QIN ZHENG, et al. Sensitive Detection of Captopril Based on “Off-On” Carbon Dots as Fluorescent Probe. [J]. 发光学报, 2022, 43(3): 430-439.
DOI：

QIAN LIANG, YU-LIN WANG, MEI-QIN ZHENG, et al. Sensitive Detection of Captopril Based on “Off-On” Carbon Dots as Fluorescent Probe. [J]. 发光学报, 2022, 43(3): 430-439. DOI： 10.37188/CJL.20210372.

摘要

以柠檬汁和尿素为原料，通过一步简单的微波热解制得了含氮荧光碳点(NCDs). 所得碳点发蓝色荧光，量子产率高达53.1%. Hg

可以与NCDs表面基团络合形成非荧光的稳定化合物，导致荧光猝灭. 通过荧光猝灭与寿命的关系和紫外-可见光谱的变化情况得出猝灭应属静态猝灭. 另外，卡托普利的加入可以使NCDs荧光得以恢复，这是因为Hg

与卡托普利的成键作用强于NCDs，卡托普利的加入使Hg

脱离NCDs表面，荧光得以恢复. 在最优化的实验条件下，卡托普利的检测范围是0.25~25 μmol·L

-1

，检出限为0.17 μmol·L

-1

. 该探针成功地用于卡托普利片剂中有效成分的测试并取得了满意的效果.

Abstract

Fluorescent nitrogen-doped carbon dots(NCDs) were synthesized by a facile one-step microwave strategy using lemon juice and urea. The obtained NCDs show stable blue fluorescence with a high quantum yield of 53.1%. Hg

can efficiently coordinate onto the surface of NCDs by means of electrostatic interactions and remarkably quench the fluorescence of NCDs as a result of the formation of a non-fluorescent stable NCDs-Hg

complex(turn-off). Static fluorescence quenching towards Hg

is proved by the fluorescence lifetime measurements and the change of ultraviolet-visible absorption spectra. In addition

the fluorescence of NCDs-Hg

system was recovered with the addition of captopril(CAP) due to the ability of captopril to coordinate with Hg

and the formation of strong Hg

—S bond. When captopril was added

combined with captopril rather than with NCDs resulting in the remove of Hg

from the surface of NCDs and a significant fluorescence restore of NCDs was observed(turn-on). Under the optimized conditions

good linearity for detecting captopril was attained over the concentration range 0.25-25 μmol·L

-1

with a detection limit of 0.17 μmol·L

-1

. Moreover

this NCDs-based sensor was successfully applied for quantitation of captopril in tablets with satisfactory recovery.

关键词

碳点荧光卡托普利Hg(Ⅱ)

Keywords

carbon dotsfluorescencecaptoprilHg(Ⅱ)

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a］ Key Laboratory of Photochemical Conversion and Optoelectronic Materials， Technical Institute of Physics and Chemistry， Chinese Academy of Sciences， Beijing， 100190， P. R. China［b］ School of Future Technology， University of Chinese Academy of Sciences， Beijing， 100049， China［c］ Department of Urology， Drum Tower Hospital， Medical School of Nanjing University， Institute of Urology， Nanjing University

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