Fluorescence Mechanism and Biomedical Applications of pH-responsive Carbon Dots

Song-jie HE; Qing-mei ZHANG; Lu-peng ZHANG; Xiu-juan DU; Feng-hua CHEN; Bing LI

doi:10.37188/CJL.20210307

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Fluorescence Mechanism and Biomedical Applications of pH-responsive Carbon Dots

Luminescence Applications and Interdisciplinary Fields | 更新时间：2022-01-14

- Fluorescence Mechanism and Biomedical Applications of pH-responsive Carbon Dots
  增强出版
- Chinese Journal of Luminescence Vol. 43, Issue 1, Pages: 137-151(2022)
- 作者机构：
  
  1.太原科技大学　应用科学学院，山西　太原　030024
  2.福建师范大学物理与能源学院　福建省量子调控与新能源材料重点实验室，福建　福州　350117
  3.山西医科大学　口腔医学院，山西　太原　030051
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China(11704274);Fujian Provincial Key Laboratory of Quantum Control and New Energy Materials Open Project(QMNEM1801);Natural Science Foundation of Shanxi Province(201901D111267);Shanxi Provincial Leading Talent Project(20190042)
- DOI：10.37188/CJL.20210307
  CLC： O482.31
- Published：2022-01，
  
  Received：24 September 2021，
  
  Revised：12 October 2021，
扫描看全文
Song-jie HE, Qing-mei ZHANG, Lu-peng ZHANG, et al. Fluorescence Mechanism and Biomedical Applications of pH-responsive Carbon Dots. [J]. Chinese Journal of Luminescence 43(1):137-151(2022)
DOI：

Song-jie HE, Qing-mei ZHANG, Lu-peng ZHANG, et al. Fluorescence Mechanism and Biomedical Applications of pH-responsive Carbon Dots. [J]. Chinese Journal of Luminescence 43(1):137-151(2022) DOI： 10.37188/CJL.20210307.

摘要

碳点(CDs)作为一种新型的零维碳基纳米材料，由于其优异的荧光性质、良好的生物兼容性、低细胞毒性以及丰富的表面官能团等性质，在荧光传感和生物医学领域具有巨大的应用潜力。特别是针对肿瘤弱酸性的微环境特点，设计pH响应型碳点来实现对肿瘤的特异性治疗将尤为重要。本文对近年来基于pH响应型碳点的研究工作进行了系统的调研，综述了pH响应型碳点的荧光机制及其在pH传感、生物成像及癌症治疗等生物医学领域的应用，并对pH响应型碳点目前面临的主要挑战以及未来发展的方向进行了展望。

Abstract

As a new type of zero-dimensional carbon-based nanomaterials

carbon dots(CDs) have a great application potential in the fields of fluorescence sensing and biomedicine due to their excellent fluorescence properties

good biocompatibility

low cytotoxicity

and large surface functional groups. Especially given the weakly acidic microenvironment characteristics of tumors

it is crucial to design pH-responsive carbon dots to achieve specific treatment. This article has conducted a systematic investigation on the research work based on pH-responsive carbon dots in recent years and reviewed the fluorescence mechanism of pH-responsive carbon dots and their applications in biomedical fields such as pH sensing

bioimaging

and cancer treatment. Finally

the main challenges currently faced by pH-responsive carbon dots and the future development direction have been prospected.

关键词

pH响应型碳点荧光机制pH传感生物成像癌症治疗

Keywords

pH-responsive carbon dotsfluorescence mechanismpH sensingbioimagingcancer treatment

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