Progress on Aggregation-induced Emission Probes for Mitochondria Target and Cancer Cell Identification

Jia-qi PENG; Ming CHEN; An-jun QIN; Ben-zhong TANG

doi:10.37188/CJL.20200351

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Progress on Aggregation-induced Emission Probes for Mitochondria Target and Cancer Cell Identification

Invited Paper | 更新时间：2021-03-19

- Progress on Aggregation-induced Emission Probes for Mitochondria Target and Cancer Cell Identification
- Chinese Journal of Luminescence Vol. 42, Issue 3, Pages: 348-360(2021)
- 作者机构：
  
  1.暨南大学化学与材料学院，广东广州　 510632；
  2.华南理工大学发光材料与器件国家重点实验室，广东省分子聚集发光重点实验室，华南理工大学-香港科技大学联合研究院，广东广州　 510640；
  3.香港科技大学化学系，人体组织功能重建国家工程技术研究中心香港分中心，中国香港　 999077
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China(21905113;21788102;51620105009);Natural Science Foundation of Guangdong Province(2020A1515010622;2019B030301003;2016A030312002);Innovation and Technology Commission of Hong Kong(ITC-CNERC14S01);Fundamental Research Funds for the Central Universities(21619316)
- DOI：10.37188/CJL.20200351
  CLC： O482.31
- Received：15 November 2020，
  
  Revised：05 December 2020，
  
  Published：01 March 2021
- 稿件说明：
移动端阅览
Jia-qi PENG, Ming CHEN, An-jun QIN, et al. Progress on Aggregation-induced Emission Probes for Mitochondria Target and Cancer Cell Identification[J]. Chinese journal of luminescence, 2021, 42(3): 348-360.
DOI：

Jia-qi PENG, Ming CHEN, An-jun QIN, et al. Progress on Aggregation-induced Emission Probes for Mitochondria Target and Cancer Cell Identification[J]. Chinese journal of luminescence, 2021, 42(3): 348-360. DOI： 10.37188/CJL.20200351.

摘要

聚集诱导发光(Aggregation-induced emission，AIE)探针由于其极高的灵敏度和极佳的光稳定性在癌症诊断和治疗等方面具有不可估量的应用前景。线粒体作为所有细胞共有的重要细胞器，在癌细胞和正常细胞中显示出明显的性质区别，因此可作为线粒体靶向AIE探针区分癌细胞与正常细胞的靶标。本文介绍了线粒体靶向AIE探针的设计方法、成像机理以及它们对癌细胞与正常细胞、循环肿瘤细胞与白细胞以及癌细胞和相关细菌与正常细胞的区别成像。这些荧光探针在癌症诊断、手术导航、癌症治疗的效果评估和后续复发监测以及细胞污染评估等方面具有广阔的应用前景。通过本文的介绍，能够让更多读者了解AIE探针在癌细胞识别方面的显著优势，激发开发性能更为丰富的探针材料和开展更为深入的研究，从而促进生物医学领域的快速发展，造福人类。

Abstract

Aggregation-induced emission(AIE) probes have shown great potential in cancer diagnosis and therapy due to their excellent sensitivity and photo-stability. Mitochondria

which is regarded as one of the most important organelles in cells

has obvious difference between cancer cells and normal cells. Thus

it is reliable to utilize mitochondria-targeted AIE probes to distinguish cancer from normal cells. In this review

we exhibit the design principle and imaging mechanism of AIE probes for mitochondria target

and their distinguishing imaging between cancer cells and normal cells

circulating tumor cells and leukocyte

and dual identification imaging of cancer cells and related bacteria. The probes show remarkable advantages in cancer diagnosis

surgical navigation

cancer treatment assessment and recurrence monitoring

and cell pollution evaluation. We hope

this review will motivate to develop more AIE probes with rich properties and conduct deeper researches to promote the rapid development of biomedical field and maintain human health.

关键词

Keywords

references

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