Lanthanide-doped Fluorescence Probes for NIR-Ⅱ Fluorescence Imaging

Song-tao ZHANG; Ying-hui WANG; Hong-jie ZHANG

doi:10.37188/CJL.20200340

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Lanthanide-doped Fluorescence Probes for NIR-Ⅱ Fluorescence Imaging

Invited Review | 更新时间：2020-12-10

- Lanthanide-doped Fluorescence Probes for NIR-Ⅱ Fluorescence Imaging
- Chinese Journal of Luminescence Vol. 41, Issue 12, Pages: 1460-1478(2020)
- 作者机构：
  
  1.中国科学院长春应用化学研究所稀土资源与利用国家重点实验室, 吉林长春 130022
  2.中国科学院大学, 北京 100049
  3.清华大学化学系, 北京 100084
- 作者简介：
- 基金信息：
  
  National Natural Science Foundation of China;National Natural Science Foundation of China;National Natural Science Foundation of China;National Natural Science Foundation of China;National Natural Science Foundation of China;Youth Innovation Promotion Association of Chinese Academy of Sciences
- DOI：10.37188/CJL.20200340
  CLC： O482.31
- Received：06 November 2020，
  
  Accepted：2020-11-12，
  
  Published：2020-12
- 稿件说明：
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Song-tao ZHANG, Ying-hui WANG, Hong-jie ZHANG. Lanthanide-doped Fluorescence Probes for NIR-Ⅱ Fluorescence Imaging[J]. Chinese journal of luminescence, 2020, 41(12): 1460-1478.
DOI：

Song-tao ZHANG, Ying-hui WANG, Hong-jie ZHANG. Lanthanide-doped Fluorescence Probes for NIR-Ⅱ Fluorescence Imaging[J]. Chinese journal of luminescence, 2020, 41(12): 1460-1478. DOI： 10.37188/CJL.20200340.

摘要

与可见光和近红外一区光相比，生物组织对近红外二区光具有更低的散射和自体荧光，因此，近红外二区荧光成像技术可以实现高灵敏度、高分辨率和高信噪比的成像，在肿瘤诊断、小分子体内检测、生物传感和免疫分析等领域展示出了广泛的应用前景。在众多的近红外二区荧光纳米材料中，稀土发光纳米材料因具有化学稳定性和光稳定性好、发射带窄、发光颜色和寿命可调等优点受到研究人员的关注。基于此，本文以稀土发光纳米材料的发光机理和设计合成为出发点，系统地综述了这类纳米材料在近红外二区荧光成像方面的最新研究进展，并对其亟需解决的问题及未来的发展趋势进行了展望。

Abstract

Compared to the visible range(Vis

400-700 nm) and first near-infrared window(NIR-Ⅰ

700-1 000 nm)

fluorescence-based imaging in the second near-infrared window(NIR-Ⅱ

1 000-1 700 nm) possesses the merits of high sensitivity

spatiotemporal resolution and signal to noise ratio(SNR) with increasing tissue penetration depths benefiting from the optical scattering and auto-fluorescence in the biological tissue

leading to widespread application in the fields of tumor diagnosis

biosensing

in vivo

molecular detection and immunoassay. Among of several NIR-Ⅱ fluorescence probes

lanthanide-doped luminescence nanomaterials have attracted more attention in development of NIR-Ⅱ fluorescence imaging

owing to the advantages of high photostability and chemostability

narrow emission band widths

tunable emission wavelength and lifetime. Therefore this work takes the mechanisms and constitutions of lanthanide-doped luminescence nanomaterials as starting points and systematically summarizes the recent progress in the biomedical imaging and biosensing applications of lanthanide-doped luminescence nanomaterials. The problem to be resolved and its future development are discussed.

关键词

Keywords

references

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