一种金纳米球复合稀土Eu3+功能纳米材料的制备及光热监测应用

陈雪桥; 王小卉; 于印霄; 韦晓菲; 程琨; 赵俊芳; 杨巍

doi:10.3788/fgxb20194011.1380

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一种金纳米球复合稀土Eu³⁺功能纳米材料的制备及光热监测应用

材料合成及性能 | 更新时间：2020-08-12

- 一种金纳米球复合稀土Eu³⁺功能纳米材料的制备及光热监测应用
- Preparation of Gold Nanospheres-attached Eu(TTA)₃(TPPO)₂-loaded Functional Nanomaterials for Photothermal Monitoring
- 发光学报 2019年40卷第11期页码：1380-1385
- 作者机构：
  
  1. 北京邮电大学电子工程学院安全生产智能监控北京市重点实验室, 北京 100876
  2. 中国科学院理化技术研究所北京,100080
- 作者简介：
- 基金信息：
  
  国家自然科学基金（61605014）;中央高校基本科研业务费专项资金（2018RC18，2018RC17）资助项目
- DOI：10.3788/fgxb20194011.1380
  中图分类号： O482.31
- 收稿日期：2019-06-02，
  
  修回日期：2019-07-07，
  
  网络出版日期：2019-06-13，
  
  纸质出版日期：2019-11-05
- 稿件说明：
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陈雪桥, 王小卉, 于印霄等. 一种金纳米球复合稀土Eu3+功能纳米材料的制备及光热监测应用[J]. 发光学报, 2019,40(11): 1380-1385

CHEN Xue-qiao, WANG Xiao-hui, YU Yin-xiao etc. Preparation of Gold Nanospheres-attached Eu(TTA)3(TPPO)2-loaded Functional Nanomaterials for Photothermal Monitoring[J]. Chinese Journal of Luminescence, 2019,40(11): 1380-1385
陈雪桥, 王小卉, 于印霄等. 一种金纳米球复合稀土Eu3+功能纳米材料的制备及光热监测应用[J]. 发光学报, 2019,40(11): 1380-1385 DOI： 10.3788/fgxb20194011.1380.

CHEN Xue-qiao, WANG Xiao-hui, YU Yin-xiao etc. Preparation of Gold Nanospheres-attached Eu(TTA)3(TPPO)2-loaded Functional Nanomaterials for Photothermal Monitoring[J]. Chinese Journal of Luminescence, 2019,40(11): 1380-1385 DOI： 10.3788/fgxb20194011.1380.

摘要

光热治疗基于光热药剂在激光照射下产生热量，进而高温杀死肿瘤细胞，因而实时监测光热过程中微观温度变化对于优化治疗效果具有十分重要的作用。稀土Eu

配合物的发光具有线谱、长荧光寿命以及对温度高度敏感的特点，利用Eu

配合物的温敏特性可检测光热过程中的温度变化，整合温度监测功能和光热特性的纳米体系在光热治疗领域具有很好的应用前景。本文制备了一种内部封装温度敏感探针Eu

配合物且表面复合金纳米球的功能纳米颗粒，将该功能纳米颗粒分散液置于不同的温度环境中，发现其荧光性能对温度具有高的响应灵敏度，即Eu

的特征发射峰（615 nm）强度随温度升高降低52.7%，表明该稀土荧光温度纳米传感器具有高的温度敏感性。在激光辐照下，功能纳米颗粒可以产生良好的光热现象，基于自身的温敏特性可实时对光热特性进行温度监控。

Abstract

Photothermal therapy is based on the heat generated by photothermal agents under laser irradiation

and then kills tumor cells at high temperature. Real-time monitoring of microscopic temperature changes in photothermal process plays a very important role in optimizing the therapeutic effect. Europium(Ⅲ) chelates display line spectrum

long fluorescence lifetime and a highly temperature-dependent emission

which can be used to detect the temperature of photothermal process. The nanosystem

integrating temperature monitoring and the photothermal property

is promissing in the field of photothermal therapy. Herein

we designed a gold nanospheres-attached Eu(TTA)

-(TPPO)

-loaded functional nanomaterials. The functional nanoparticle displays good temperature-dependent fluorescence performance. The emission peak(615 nm) of Eu

decreases up to 52.7% from 35℃ to 65℃

indicating that the nanoparticles has high temperature sensitivity. Under laser irradiation

functional nanoparticles can produce photothermal effects

and real-time temperature monitoring of photothermal process can be performed based on its own temperature sensitivity.

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references

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