Preparation, Characterization and Research of Modified Carboxymethyl Chitosan Composite

DONG Li-dan; WEI Chang-ping; LI Zhong-tian; WANG Feng-ming

doi:10.3788/fgxb20183909.1207

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Preparation, Characterization and Research of Modified Carboxymethyl Chitosan Composite

更新时间：2020-08-12

- Preparation, Characterization and Research of Modified Carboxymethyl Chitosan Composite
- Chinese Journal of Luminescence Vol. 39, Issue 9, Pages: 1207-1212(2018)
- 作者机构：
  
  1. 长春理工大学材料科学与工程学院,吉林长春,130022
  2. 长春医学高等专科学校,吉林长春,130031
  3. 中水东北勘测设计研究有限责任公司,吉林长春,130061
- 作者简介：
- 基金信息：
- DOI：10.3788/fgxb20183909.1207
  CLC： TP394.1;TH691.9
- Received：02 April 2018，
  
  Revised：04 May 2018，
  
  Published Online：21 May 2018，
  
  Published：05 September 2018
- 稿件说明：
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董丽丹, 魏长平, 李中田等. 改性羧甲基壳聚糖复合材料的制备、表征与研究[J]. 发光学报, 2018,39(9): 1207-1212

DONG Li-dan, WEI Chang-ping, LI Zhong-tian etc. Preparation, Characterization and Research of Modified Carboxymethyl Chitosan Composite[J]. Chinese Journal of Luminescence, 2018,39(9): 1207-1212
董丽丹, 魏长平, 李中田等. 改性羧甲基壳聚糖复合材料的制备、表征与研究[J]. 发光学报, 2018,39(9): 1207-1212 DOI： 10.3788/fgxb20183909.1207.

DONG Li-dan, WEI Chang-ping, LI Zhong-tian etc. Preparation, Characterization and Research of Modified Carboxymethyl Chitosan Composite[J]. Chinese Journal of Luminescence, 2018,39(9): 1207-1212 DOI： 10.3788/fgxb20183909.1207.

摘要

为了提高壳聚糖的水溶性及其止血方面的性能，将壳聚糖（CS）进行羧甲基化改性，并引入具有抗菌作用的Ag

和TiO

，制备出羧甲基壳聚糖复合止血材料。首先，在壳聚糖中引入羧甲基，制得羧甲基壳聚糖（CMCS），之后向其中引入Ag

和TiO

，分别制备出Ag

-CMCS、TiO

-CMCS和Ag

-TiO

-CMCS复合材料。然后，采用FTIR、XRD、SEM等手段对复合材料的结构进行表征。最后，对复合物的凝血、止血性能进行了测试。实验结果表明：改性后的羧甲基壳聚糖的IR图谱在3 423 cm

-1

和1 380 cm

-1

处出现了羧甲基壳聚糖钠盐的特征吸收峰。改性后的羧甲基壳聚糖在XRD图谱中表现出了金属晶态。CMCS的粒径为14.8 nm左右，Ag

粒径为143.5 nm左右，纳米TiO

的粒径为267.2 nm左右，且三者分散的很均匀。Ag

-TiO

-CMCS的凝血、止血效果要优于Ag

-CMCS和TiO

-CMCS，同时Ag

-CMCS和TiO

-CMCS的凝血、止血效果要优于CMCS。

Abstract

In order to improve the water soluble and the hemostatic performance of chitosan

the chitosan(CS) was modified by carboxymethylation

and Ag

and TiO

with antibacterial action were introduced. In this way

carboxymethyl chitosan composite hemostatic material was prepared. Firstly

in chitosan

carboxymethyl was introduced

and carboxymethyl chitosan(CMCS) was prepared

then Ag

and TiO

were introduced

and Ag

-CMCS

TiO

-CMCS and Ag

-TiO

-CMCS composites were prepared

respectively. Then

FTIR

XRD and SEM were used to characterize the structure of composites. Finally

the coagulation and hemostatic properties of the complex were tested. There are characteristic absorption peaks of carboxymethyl chitosan sodium salt around 3 423 cm

-1

and 1 380 cm

-1

in the IR spectra of modified carboxymethyl chitosan. The XRD shows it is metals crystalline. The average diameter of CMCS is about 14.8 nm

is 143.5 nm

nanometre TiO

is 267.2 nm

and all of them are homodisperse. The properties of crour and hemostasis of Ag

-TiO

-CMCS are superior to Ag

-CMCS and TiO

-CMCS

while Ag

-CMCS and TiO

-CMCS also have an advantage over CMCS.

关键词

Keywords

references

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