DONG Li-dan, WEI Chang-ping, LI Zhong-tian etc. Preparation, Characterization and Research of Modified Carboxymethyl Chitosan Composite[J]. Chinese Journal of Luminescence, 2018,39(9): 1207-1212
DONG Li-dan, WEI Chang-ping, LI Zhong-tian etc. Preparation, Characterization and Research of Modified Carboxymethyl Chitosan Composite[J]. Chinese Journal of Luminescence, 2018,39(9): 1207-1212 DOI: 10.3788/fgxb20183909.1207.
Preparation, Characterization and Research of Modified Carboxymethyl Chitosan Composite
In order to improve the water soluble and the hemostatic performance of chitosan
the chitosan(CS) was modified by carboxymethylation
and Ag
+
and TiO
2
with antibacterial action were introduced. In this way
carboxymethyl chitosan composite hemostatic material was prepared. Firstly
in chitosan
carboxymethyl was introduced
and carboxymethyl chitosan(CMCS) was prepared
then Ag
+
and TiO
2
were introduced
and Ag
+
-CMCS
TiO
2
-CMCS and Ag
+
-TiO
2
-CMCS composites were prepared
respectively. Then
FTIR
XRD and SEM were used to characterize the structure of composites. Finally
the coagulation and hemostatic properties of the complex were tested. There are characteristic absorption peaks of carboxymethyl chitosan sodium salt around 3 423 cm
-1
and 1 380 cm
-1
in the IR spectra of modified carboxymethyl chitosan. The XRD shows it is metals crystalline. The average diameter of CMCS is about 14.8 nm
Ag
+
is 143.5 nm
nanometre TiO
2
is 267.2 nm
and all of them are homodisperse. The properties of crour and hemostasis of Ag
+
-TiO
2
-CMCS are superior to Ag
+
-CMCS and TiO
2
-CMCS
while Ag
+
-CMCS and TiO
2
-CMCS also have an advantage over CMCS.
关键词
Keywords
references
郭苗苗, 浦金辉, 徐丹, 等. 壳聚糖基快速止血材料的研究进展[J]. 中国医院药学杂志, 2012, 32(1):49-51. GUOM M, PU J H, XU D, et al.. The research progress of chitosan fast hemostatic materials[J]. Chin. Hosp. Pharm. J., 2012, 32(1):49-51. (in Chinese)
SALGADO C L, GRENHO L, FERNANDES M H, et al.. Biodegradation, biocompatibility, and osteoconduction evaluation of collagen Nanohydroxyapatite cryogels for bone tissue regeneration[J]. J. Biomed. Mater. Res. Part A, 2016, 104(1):57-70.
石凉, 汪涛, 吴大洋. 壳聚糖止血材料及最新研究进展[J]. 蚕业科学, 2009, 35(4):929-934. SHI L, WANG T, WU D Y. The latest research progress hemostatic properties of chitosan[J]. Canye Kexue, 2009,35(4):929-934. (in Chinese)
WALTERS B D, STEGEMANN J P. Strategies for directing the structure and function of three-dimensional collagen biomaterials across length scales[J]. Acta Biomater., 2014, 10(4):1488-1501.
UITTE DE WILLIGE S, MIEDZAK M, CARTERAM, et al.. Oteolytic and genetic variation of the alpha-2-antiplasmin c-terminus in myocardial infarction[J]. Blood, 2011, 117(24):6694-6701.
XIE H, TEACH J S, BURKE A P, et al.. Laparoscopic repair of inferior vena caval injury using a chitosan-based hemostatic dressing[J]. Am. J. Surg., 2009, 197(4):510-514.
巴根, 赵贵成, 傅强. 可吸收止血材料的安全性与临床应用[J]. 第二军医大学学报, 2011, 32(8):911-914. BA G, ZHAO G C, FU Q. Absorbable hemostatic materials:safety and clinical application[J]. Acad. J. Second Milit. Med. Univ., 2011, 32(8):911-914. (in Chinese)
尹刚, 侯春林, 刘万顺, 等. 新型壳聚糖止血粉止血作用的实验研究[J]. 中国修复重建外科志, 2009, 23(11):1371-1349. YIN G, HOU C L, LIU W S, et al.. Experiment study on hemostasis of a new chitosan hemostatic powder[J]. Chin. J. Reparat. Reconstruct. Surg., 2009, 23(11):1371-1349.
庄金娟, 王香梅. 改性壳聚糖的研究进展及其应用前景[J]. 天津化工, 2011, 25(2):7-9. ZHUANG J J, WANG X M. The research progress and application prospect of modified chitosan[J]. Tianjin Chem. Ind., 2011, 25(2):7-9. (in Chinese)
孙磊. 高粘度壳聚糖止血材料的制备及其应用性研究[D]. 北京:中央民族大学, 2012. SUN L. Preparation and Application of High Viscosity Chitosan Hemostatic Materials[D]. Beijing:Minzu University of China, 2012. (in Chinese)
MAKOTO A, TAKESHI E, NOBUKO E, et al.. Antioxidant effects of a dietary supplement:reduction of indices of oxidative stress in normal subjects bywater-soluble chitosan[J]. Food Chem. Toxicol., 2009, 47(1):104-109.
PANWAR P, LAMOUR G, MACKENZIE N C W, et al..Changes in structural-mechanical properties and degradability of collagen during aging-associated modifications[J]. J. Biolog. Chem., 2015, 290(38):23291-23306.
BADYLAK S F, FREYTES D O, GILBERT T W. Reprint of:extracellular matrix as a biological scaffold material:structure and function[J]. Acta Biomater., 2015, 23:S17-S26.
何小松. 改性TiO2光催化杭菌材料的制备与性能研究[D]. 武汉:武汉理工大学, 2011. HE X S. Study on Preparation and Properties of Modified TiO2 Photocatalysis[D]. Wuhan:Wuhan University of Technology, 2011. (in Chinese)
ZHANG H, ZHANG J, SUN R, et al.. Preparation of magnetic and photocatalytic cenosphere deposited with Fe3O4/SiO2/Eu-doped TiO2 core/shell nanoparticles[J]. J. Mater. Res., 2015, 30(23):3700-3709.
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