Controllable Synthesis, Photothermal Conversion and in vitro Photothermal Therapy of Gold Nanostars/Nanobipyramids

WU Di; FAN Miao; ZHANG Lu-yun; XING Jing-jing; LYU Shu-fang; ZENG Le-yong

doi:10.3788/fgxb20183903.0280

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Controllable Synthesis, Photothermal Conversion and in vitro Photothermal Therapy of Gold Nanostars/Nanobipyramids

更新时间：2020-08-12

- Controllable Synthesis, Photothermal Conversion and in vitro Photothermal Therapy of Gold Nanostars/Nanobipyramids
- Chinese Journal of Luminescence Vol. 39, Issue 3, Pages: 280-286(2018)
- 作者机构：
  
  河北大学化学与环境科学学院,河北保定,071002
- 作者简介：
- 基金信息：
- DOI：10.3788/fgxb20183903.0280
  CLC： O482.31
- Received：14 September 2017，
  
  Revised：13 December 2017，
  
  Published：05 March 2018
- 稿件说明：
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吴頔, 樊淼, 张露云等. 金纳米星/双锥的可控制备、光热转换及体外光热治疗[J]. 发光学报, 2018,39(3): 280-286

WU Di, FAN Miao, ZHANG Lu-yun etc. Controllable Synthesis, Photothermal Conversion and in vitro Photothermal Therapy of Gold Nanostars/Nanobipyramids[J]. Chinese Journal of Luminescence, 2018,39(3): 280-286
吴頔, 樊淼, 张露云等. 金纳米星/双锥的可控制备、光热转换及体外光热治疗[J]. 发光学报, 2018,39(3): 280-286 DOI： 10.3788/fgxb20183903.0280.

WU Di, FAN Miao, ZHANG Lu-yun etc. Controllable Synthesis, Photothermal Conversion and in vitro Photothermal Therapy of Gold Nanostars/Nanobipyramids[J]. Chinese Journal of Luminescence, 2018,39(3): 280-286 DOI： 10.3788/fgxb20183903.0280.

摘要

采用种子生长法，分别制备了金纳米星和金纳米双锥，利用透射电子显微镜、紫外-可见（UV-Vis）分光光度计等对样品进行了表征，并评价了金纳米星和金纳米双锥的光热转换性能、生物相容性以及体外光热治疗性能。结果表明，金纳米星和金纳米双锥的UV-Vis吸收峰位于808 nm和815 nm左右。在808 nm激光辐照下，光热转换效率分别为48.43%和53.68%。细胞实验表明，金纳米星和金纳米双锥具有良好的生物相容性。808 nm激光辐照5 min后，MCF-7细胞存活率分别降至22.54%和13.73%；且在同等条件下，金纳米双锥具有更加优异的光热治疗性能，是一种安全、高性能的肿瘤光热治疗用纳米探针材料。

Abstract

Using seed-growth method

gold nanostars and gold nanobipyramids were synthesized

respectively

and they were characterized by transmission electron microscope and ultraviolet-visible (UV-Vis) spectrophotometer. Moreover

the photothermal conversion

biocompatibility and

in vitro

photothermal therapy (PTT) of gold nanostars and gold nanobipyramids were evaluated. The results show that the UV-Vis absorption peaks of gold nanostars and gold nanobipyramids are located at about 808 nm and 815 nm

and the photothermal conversion efficiency is calculated to be 48.43% and 53.68%. The cell experiments indicate that the gold nanostars and gold nanobipyramids have good biocompatibility

and the viabilities of MCF-7 cells incubate with gold nanostars and gold nanobipyramids are decreased to be about 22.54% and 13.73%

after they are irradiated by 808 nm laser for 5 min

respectively. Furthermore

compared with the gold nanostars

the gold nanobipyramids have more excellent PTT performance

which could be good candidate as safe and high-efficient nanoprobe material for PTT in tumors.

关键词

Keywords

references

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