DNA Binding Activity of Copper Complex with Schiff Base Derived from Oligochitosan and Furfuraldehyde

LI Xiao-fang; FENG Xiao-qiang; ZHU Yuan-cheng

doi:10.3788/fgxb20173810.1359

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DNA Binding Activity of Copper Complex with Schiff Base Derived from Oligochitosan and Furfuraldehyde

更新时间：2020-08-12

- DNA Binding Activity of Copper Complex with Schiff Base Derived from Oligochitosan and Furfuraldehyde
- Chinese Journal of Luminescence Vol. 38, Issue 10, Pages: 1359-1365(2017)
- 作者机构：
  
  天水师范学院化学工程与技术学院,甘肃天水,741001
- 作者简介：
- 基金信息：
  
  Supported by Youth Science and Technology Fund Program of Gansu Province(1606RJYE247);Science and Technology Support Project of Tianshui City(2016);Scientific Research Project Higher Education Institutions of Gansu Province (2016B-071);Research Project for Young and Middle-aged Teachers of Tianshui Normal University(TSA1508)。
- DOI：10.3788/fgxb20173810.1359
  CLC： O611.4
- Received：18 March 2017，
  
  Revised：18 August 2017，
  
  Published Online：21 August 2017，
  
  Published：05 October 2017
- 稿件说明：
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李小芳, 冯小强, 朱元成. 糠醛缩壳寡糖席夫碱及Cu（Ⅱ）配合物与DNA之间的作用机制[J]. 发光学报, 2017,38(10): 1359-1365

LI Xiao-fang, FENG Xiao-qiang, ZHU Yuan-cheng. DNA Binding Activity of Copper Complex with Schiff Base Derived from Oligochitosan and Furfuraldehyde[J]. Chinese Journal of Luminescence, 2017,38(10): 1359-1365
李小芳, 冯小强, 朱元成. 糠醛缩壳寡糖席夫碱及Cu（Ⅱ）配合物与DNA之间的作用机制[J]. 发光学报, 2017,38(10): 1359-1365 DOI： 10.3788/fgxb20173810.1359.

LI Xiao-fang, FENG Xiao-qiang, ZHU Yuan-cheng. DNA Binding Activity of Copper Complex with Schiff Base Derived from Oligochitosan and Furfuraldehyde[J]. Chinese Journal of Luminescence, 2017,38(10): 1359-1365 DOI： 10.3788/fgxb20173810.1359.

摘要

以糠醛和壳寡糖反应生成的席夫碱，与不同摩尔比的Cu

配位合成配合物FCOS-Cu11、FCOS-Cu13和FCOS-Cu31，并研究配合物与DNA之间的作用机制。采用循环伏安、紫外-可见吸收光谱、粘度和DNA熔点测定的方法，分别研究了席夫碱及配合物与DNA之间的作用机制。合成的3种配合物具有电化学活性。加入DNA后，配合物的氧化峰电流减小，峰电位微弱移动。配合物的吸收峰强度减色显著，同时伴有峰位红移现象。配合物加入后，DNA的相对粘度和熔点呈增大趋势。结果表明，席夫碱及配合物与DNA之间存在嵌插结合，且3种配合物中的Cu

含量与DNA的嵌插作用强度有关，结合强度依次为FCOS-Cu11

FCOS-Cu13

FCOS-Cu31。

Abstract

Schiff base was synthesized by the reaction of oligochitosan with furfuraldehyde

and acted it as ligand to prepare different molar Schiff base copper complexes which possessed electrochemical activity. The action mechanism of the complex and DNA was studied by spectrometry

viscosity measurement

cyclic voltammeiry and melting point experiment. The results indicate that the reaction of central Cu

at glassy carbon electrodes is controlled by diffusion process mechanism. The intensity of the maximal absorption peaks of the complexes is weakened with the increasing of DNA concentration

and the oxidation peak current is decreased but no new redox peak appeared. At the same time

the viscosity and melting point of DNA are increased. There are intercalation action between the complex and DNA

and DNA-binding ability order is FCOS-Cu11

FCOS-Cu13

FCOS-Cu31.

关键词

Keywords

references

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