Electrochemical Property and Interaction of DNA with 1,10-phenanthroline and Salicylic Acid Copper Complex

LI Xiao-fang; FENG Xiao-qiang; YANG Sheng; ZHU Yuan-cheng

doi:10.3788/fgxb20163706.0744

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Electrochemical Property and Interaction of DNA with 1,10-phenanthroline and Salicylic Acid Copper Complex

更新时间：2020-08-12

- Electrochemical Property and Interaction of DNA with 1,10-phenanthroline and Salicylic Acid Copper Complex
- Chinese Journal of Luminescence Vol. 37, Issue 6, Pages: 744-750(2016)
- 作者机构：
  
  1. 天水师范学院化工学院,甘肃天水,741001
  2. 定西师专化学系,甘肃定西,743000
- 作者简介：
- 基金信息：
  
  "
- DOI：10.3788/fgxb20163706.0744
  CLC： O614
- Received：17 January 2016，
  
  Revised：22 March 2016，
  
  Published：05 June 2016
- 稿件说明：
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李小芳, 冯小强, 杨声等. 邻菲啰啉和水杨酸构筑铜配合物的电化学行为及与DNA的相互作用[J]. 发光学报, 2016,37(6): 744-750

LI Xiao-fang, FENG Xiao-qiang, YANG Sheng etc. Electrochemical Property and Interaction of DNA with 1,10-phenanthroline and Salicylic Acid Copper Complex[J]. Chinese Journal of Luminescence, 2016,37(6): 744-750
李小芳, 冯小强, 杨声等. 邻菲啰啉和水杨酸构筑铜配合物的电化学行为及与DNA的相互作用[J]. 发光学报, 2016,37(6): 744-750 DOI： 10.3788/fgxb20163706.0744.

LI Xiao-fang, FENG Xiao-qiang, YANG Sheng etc. Electrochemical Property and Interaction of DNA with 1,10-phenanthroline and Salicylic Acid Copper Complex[J]. Chinese Journal of Luminescence, 2016,37(6): 744-750 DOI： 10.3788/fgxb20163706.0744.

摘要

合成了一种新型的三元铜配合物[Cu(phen)(SA)

O(phen=1

10-邻菲啰啉

SA=水杨酸)

并以鲱鱼精DNA为靶点

通过紫外吸收光谱法、循环伏安法、差分脉冲伏安法和DNA粘度滴定实验

探讨了配合物与DNA的键合方式。结果表明

SA的羧酸根离子与Cu

单齿配位

phen的两个氮原子与Cu

呈双齿配位

形成的配合物在0.489V/0.050V处呈现一对明显的准可逆氧化还原峰

并且中心Cu

在玻碳电极上的反应主要由扩散过程控制。配合物与DNA作用时

可观察到配合物的紫外光谱出现明显的减色效应

但是红移现象不明显

氧化还原峰的电流减小

峰电位发生正移

并且DNA的粘度随配合物的加入而增大。结论认为

配合物以嵌插方式与DNA发生作用形成1:1的复合物

但插入程度较弱(结合常数为1.5510

Lmol

-1

)。

Abstract

A new ternary complex of [Cu(phen)(SA)

O (phen=1

10-phenanthroline

SA=salicylic acid) was synthesized and the electrochemical behavior was studied. In addition

with hsDNA as the research target

the interaction between the complex and hsDNA was investigated by UV absorption spectroscopy

CV method

differential pulse voltammetry (DPV)

and DNA viscosity titration experiment. The experiment results indicate that COOH of SA and N of phen are liganded with Cu

. Cyclic voltammetric shows that the complex has one pairs of redox peaks at 0.489 V/0.050 V

and the reaction of Cu

on the electrode is controlled by diffusion. With the addition of hsDNA

the UV absorption peaks of complex red-shift and the intensity is weakened

the peak current decreases significantly and the potential moves positively

and the relative viscosity of hsDNA increases. It's concluded that [Cu(phen)(SA)

O and hsDNA bind by the mode of intercalation

the combining ratio and the binding constant are 1:1 and 1.5510

Lmol

-1

respectively.

关键词

Keywords

references

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