Synthesis of Magnetic Resonance/Fluorescence Bimodal Molecular Imaging Probe Based on Gadolinium-doped Carbon Quantum Dots by Microwave-hydrothermal Method

YUAN Xue-xia; WANG Chao; WANG Yu-ping; HU Qing; REN Xian-yan

doi:10.3788/fgxb20153612.1383

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Synthesis of Magnetic Resonance/Fluorescence Bimodal Molecular Imaging Probe Based on Gadolinium-doped Carbon Quantum Dots by Microwave-hydrothermal Method

更新时间：2020-08-12

- Synthesis of Magnetic Resonance/Fluorescence Bimodal Molecular Imaging Probe Based on Gadolinium-doped Carbon Quantum Dots by Microwave-hydrothermal Method
- Chinese Journal of Luminescence Vol. 36, Issue 12, Pages: 1383-1389(2015)
- 作者机构：
  
  1. 西南科技大学材料科学与工程学院, 四川绵阳 621010
  2. 北川天诺光电材料有限公司, 四川绵阳 622750
- 作者简介：
- 基金信息：
- DOI：10.3788/fgxb20153612.1383
  CLC： O482.31
- Received：26 August 2015，
  
  Revised：21 October 2015，
  
  Published：10 December 2015
- 稿件说明：
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袁雪霞, 王超, 王玉平等. 微波水热法制备Gd<sup>3+</sup>掺杂的碳量子点型高性能磁共振-荧光双模态分子影像探针[J]. 发光学报, 2015,36(12): 1383-1389

YUAN Xue-xia, WANG Chao, WANG Yu-ping etc. Synthesis of Magnetic Resonance/Fluorescence Bimodal Molecular Imaging Probe Based on Gadolinium-doped Carbon Quantum Dots by Microwave-hydrothermal Method[J]. Chinese Journal of Luminescence, 2015,36(12): 1383-1389
袁雪霞, 王超, 王玉平等. 微波水热法制备Gd<sup>3+</sup>掺杂的碳量子点型高性能磁共振-荧光双模态分子影像探针[J]. 发光学报, 2015,36(12): 1383-1389 DOI： 10.3788/fgxb20153612.1383.

YUAN Xue-xia, WANG Chao, WANG Yu-ping etc. Synthesis of Magnetic Resonance/Fluorescence Bimodal Molecular Imaging Probe Based on Gadolinium-doped Carbon Quantum Dots by Microwave-hydrothermal Method[J]. Chinese Journal of Luminescence, 2015,36(12): 1383-1389 DOI： 10.3788/fgxb20153612.1383.

摘要

以同时提供钆源和碳源的钆喷酸单葡甲胺为前驱体

利用微波作为加热手段实现分子水平上的搅拌

达到低温、短时间内制得均匀的小粒度Gd

掺杂碳量子点(Gd

/CQDs-MH)的目的。当前驱体在250 ℃下微波水热反应45 min时

获得的Gd

/CQDs-MH表现出较高的量子产率和极强的磁共振性能

避免了传统加热方式对碳量子点的发光能力和弛豫性能极难同时提高的矛盾。该条件下合成出尺寸约1.0 nm的碳量子点

其荧光量子产率为11.0%

的掺杂质量分数达16.9%

纵向弛豫性能高达4 545.3 mmol

-1

([Gd

]=0.01 mmolL

-1

)。并且

该碳量子点对HeLa细胞无明显毒性

有望用作高弛豫性能和高发光性能的磁共振-荧光双模态探针。

Abstract

Using gadopentetic acid monomeglumine (GdPM) as precursor to provide simultaneously the carbon source and gadolinium (3+) source

gadolinium-doped carbon quantum dots (Gd

/CQDs-MH) with uniformly small size were obtained at a mild condition by microwave hydrothermal method which can realize a molecular level mixing. When GdPM was pyrolyzed under 250 ℃ for 45 min

/CQDs-MH with high quantum yield (QY) and longitudinal relaxation rate (

) were obtained. The contradiction between quantum yield and the relaxation properties has been well balanced

which is very difficult to avoid using traditional heating method. The prepared Gd

/CQDs-MH with an average diameter of about 1.0 nm show little cell toxicity and exhibit a high photoluminescence quantum yield of 11.0%

as well as a high

value of 4 545.3 mmol

-1

([Gd

]=0.01 mmolL

-1

) with the doping mass fraction of gadolinium (3+) of 16.9%. Therefore

the Gd

/CQDs-MH show big possibility for application in magnetic resonance/fluorescence bimodal molecular imaging.

关键词

Keywords

references

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Yang Y, Cui J, Zheng M, et al. One-step synthesis of amino-functionalized fluorescent carbon nanoparticles by hydrothermal carbonization of chitosan [J]. Chem. Commun., 2012, 48(3):380-382.

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Ren, X Y, Liu L H, Li Y, et al. Facile preparation of gadolinium(iii) chelates functionalized carbon quantum dot-based contrast agent for magnetic resonance/fluorescence multimodal imaging [J]. J. Mater. Chem. B, 2014, 2(34):5541-5549.

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Dong Y G, Yang J L, Ding Y L, et al. Size-controllable synthesis of highly fluorescent carbon quantum dots in a reverse microemusion [J]. Chin. J. Lumin.(发光学报), 2015, 36(2):157-162 (in Chinese).

Shi X, Xu J P, Li L L, et al. Photoelectro chemical properties of TiO2 nanorod arrays loaded with carbon quantum dots [J]. Chin. J. Lumin.(发光学报), 2015, 36(8):898-905 (in Chinese).

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Sitharaman B, Kissell K R, Hartman K B, et al. Superparamagnetic gadonanotubes are high-performance MRI contrast agents [J]. Chem. Commun., 2005, 41(31):3915-3917.

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Related Author

REN Xian-yan

LIU Li-hua

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LI Ziyue

SHEN Yi

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Related Institution

School of Science, Xi'an Jiaotong University

School of Materials Science and Engineering, Southwest University of Science and Technology

First Affiliated Hospital of Xi'an Jiaotong University

State Key Laboratory of Integrated Optoelectronics， College of Electronic Science and Engineering， Jilin University

Department of Plastic and Aesthetic Surgery， The First Hospital of Jilin University

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